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Journey of a Drug: Design to Market Seller
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Where do the medicines we take from chemists come from? How do the doctors know which drug is good for which disease? How the medicines really are able to cure a particular ailment they have been prescribed for? Do these questions come to your mind, whenever you buy any medicine?

Come, let us today know about the medicine development from the beginning …

The development of medicine is called a Clinical Research and has different Phases. Phases of the clinical research are the steps of experiments with a health intervention in an attempt to find enough evidence for a process which the scientists think would be helpful in medical treatment.

The pharmaceutical study starts its journey from a drug design and drug molecule discovery which further progresses into animal testing and then human studies to see the drug's effectiveness.

Drug undergoes many trials- Preclinical, Phase 0, Phase I, II, III and IV. Sometimes combined trials also are undertaken to reduce the time of development, like Phase I / II and II / III.

Pre-Clinical Study

When the drug molecule is identified, it undergoes many in vitro ( test tube or cell culture ) and in vivo ( animal ) experiments. These experiments are conducted to know the preliminary efficacy, toxicity, and pharmacokinetics of the various doses of the drug. Many drug molecules are designed at a time and these pre-clinical studies let the pharmaceutical companies decide which molecule has a greater potential in further studies.

Design of the Studies:

Trials are always conducted by following the set of steps, called the protocol, developed by the researchers to find the specific questions related to the medical product. Information from the prior studies become the base for the researchers to develop research questionnaire and objectives:
- Participant selection
- Number of participants
- Duration of the study
- Controlled or not
- How and what dosage will be given
- What and when the data will be collected
- Review and analysis time
Phase 0 Study

It is also called micro-dosing trials, 10-15 human subjects are taken and single sub-therapeutic doses are administered to gather the pharmacokinetic ( PK ) data of the drug. This enables the company in deciding to go or no go for the further development of the drug, based on more relevant human data instead of animal data.

Such trials exceed the speed of promising drug development by establishing whether or not the drug acts on humans as expected in pre-clinical studies.

After the company decides to take the molecule of the drug forward in development, it will have to submit the data of its preliminary studies to the FDA called Investigational New Drug ( IND ) application filing.

Phase I Study

Also called First-in-man studies as these are the first stage of human testing studies. These are the studies which are designed to determine the maximum dose that can be administered without showing adverse effects.

Contract Research Organizations ( CROs ) conduct such studies in the clinical trial clinics where medical staff provides full-time attention to 2-100 healthy subjects enrolled for the study and collects the data.

These studies determine the safety ( pharmacovigilance ), tolerability, pharmacokinetics ( PK ) and pharmacodynamics ( PD ) of the drug. The design of Phase I studies is dose-ranging also called dose escalation studies conducted in controlled clinics called Central Pharmacological Units ( CPUs ).

Usually, healthy subjects are hired but sometimes terminally ill patients like of cancer and HIV and also those who have already tried and failed to improve on existing medications.

There are two divisions for Phase I study:

Phase Ia: Single ascending dose

Phase Ib: Multiple ascending dose

Phase II Study

More than 100 diseased subjects are enrolled for a longer period study, to know the benefits of the drug along with its safety which includes genetic testing. These studies are also called as "Proof of Concept or Pilot" studies.

This is the phase when the drug's development can fail due to toxicity or less than expected results.

Two divisions of this phase are:

Phase IIa: Pilot study, to determine the clinical efficacy or the biological activity.

Phase IIb: Dose-finding study, to check the biological activity with minimal side-effects.

A combined trial determining the efficacy as well as toxicity are Phase I / II trials.

Phase III Study

These are pre-registration trials means the data of this study is submitted to the regulatory agency through New Drug Application (NDA) for its registration. Also called Pre-marketing or Pivotal trials.

Such studies are multicentral, randomized, in large diseased population ( more than 500 ) with much longer duration of treatment and short follow up period, to determine the long-term safety and efficacy of the drug.

Even if the regulatory submission is pending, the drug is received by the patients in case it's a lifesaving drug until the drug can be purchased.

'Label expansion' that is drug can treat an additional disease, other than the disease for which the drug is already approved, may also be the reason for running the Phase III trial.

It is said that for FDA ( United States Food and Drug Administration ) and MHRA ( United Kingdom's Medicines and Health products Regulatory Agency ) needs at least two trials of successful trials data to register the drug.

After these trials, the drug is approved for market selling.

Phase IV Study

These are Post Market Safety Monitoring studies done after the drug is registered. Also called Late Phase or Confirmatory trials.

This kind of study determines the long-term adverse effects on the much larger population for a very long duration (at least 2 years). If harmful effects are detected in this study, then the drug is disapproved and the company has to retrieve the drug from the market as it can no longer be sold.

The entire journey of the drug from a molecule to a market selling product takes around 15-20 years.

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Source by Nidhi Sharma

Views: 0
July 27, 2022
Understanding Young Living: Can You Really Make Money With Young Living?
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Young Living is a Muli-Level Marketing company founded in 1993 offering essential oils and other related products. Additionally, they offer a business or income opportunity for those interested in marketing the company or their products to make an income stream. Something I think is neat is Young Living also has a non-profit organization that helps communities and families in impoverished areas in Ecuador, Croatia, and Uganda.

The Thing:

Young Living has a ton of products available based around essential oils. Some of the items they offer are Aroma Oils, Massage Oils, Diffusers, Oral Care Products, Healthy Cooking Oils, Animal Care Oils, Home Purification Oils, and of course accessories to carry your oils.
1. Idaho Blue Spruce – This oil is designed to relax both mind and body and sells Retail value for $37.83.
2. Animal Shampoo – No Kidding. This product contains several different oils including YLTG oil formulated by D. Gary Young and sells Retail Value for $20.72.
3. Thieves Fresh Essence Mouthwash – This mouthwash is designed to thoroughly clean your mouth and comes in Spearmint and Peppermint flavor, selling 8 oz Retail Value for $14.47.
It’s important to note, Young Living offers several different types of products! The categories of products and actual product in which I explained are far from all Young Living has to offer!

The Opportunity:

The question still remains; can you really make money with Young Living? In order to answer this question, we must look into their compensation plan!

There are 3 Main payouts for people affiliated with Young Living such as Fast Start Bonus, Start Living Bonus, and Retail Earnings.
1. Fast Start Bonus – You can earn 25% on your first-level personally enrolled distributors’ orders during the first three months of being a member. You can also earn an additional 10% on your second-level personally enrolled distributors’ orders.
2. Start Living Bonus – Each time you enroll a distributor with a Premium Starter Kit, you can earn a one-time $25 cash bonus.
3. Retail Earnings – With this payout you’ll be able to earn the 24% difference between the Retail and Wholesale price for the orders of your personally enrolled retail customers.
To Conclude, Yes, You Can Make Money With Young Living!

The Cost:

For some, this is the most important question that has to be answered before even considering joining this business! I would be more than happy to be the provider of that answer!

But first, understand that if you want to get involved with Young Living and begin making money, what you are doing is opening up your own business from home! All businesses require some type of start-up fee! However, in the world of Multi-Level Marketing, the price is generally much cheaper in comparison to a traditional type company. For example, in a traditional type business, such as Construction, you could spend around $5,000 to $10,000 just getting the thing started! In this industry, you likely will spend far less than that! Since we have been able to get that understood, let’s move on.

In order to become involved and get started with Young Living, you will need to purchase a Starter Kit! They have several starter kits available; I will give a brief explanation of three of them!
1. Basic Starter Kit – $45.00. This kit includes one 5ml Stress Away Oil, AromaGlide Roller Fitment, 10 Sample Packets, 10 Love It? Share It! Business Cards, 10 Love It? Share It! Sample Oil Bottles, 2 NingXia Red 2-oz. samples, Product Guide and Product Price List, Essential Oil Magazine, Essential Edge, and member resources.
2. Thieves Premium Kit – $160.00. This kit is a specialty premium starter kit and includes 15-ml Thieves Oil, Thieves AromaBright Toothpaste, Thieves Fresh Essence Plus Mouthwash, 2 Thieves Cleaner, 2 Thieves Foaming Hand Soap, 2 Thieves Spray, 2 Thieves Waterless Hand Purifier, and everything included in the Basic Starter Kit mentioned above.
3. NingXia Premium Kit – $170.00. This kit is also a specialty premium kit and includes NingXia Red 2-Pack, 30 NingXia Red Single Oils, NingXia Nitro, and everything includes in the Basic Started Kit above.
Final Thoughts:

The products offered by Young Living are interesting and definitely have some kind of originality to them. They also have a ton of products to choose from!

The business opportunity is something you can definitely make money from. However, in my opinion, I believe their compensation plan is kind of weak in a comparison level to other companies in which I have done reviews over. If you know exactly what you are doing and are a professional Network Marketer, you will do fine with this company and even prosper. However, if you are a total newbie and have no idea how to generate massive income from Network Marketing, you will have difficult times making money in this company.

The cost is overall pretty inexpensive. Their Basic Starter Kit is only $45.00 and their most expensive kit is $260.00. That means, you can start a business and begin generating income all from home for a little under $300.00, which is awesome!

*Dustin Hale is NOT affiliated with Young Living or their business/income opportunity

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Source by Dustin Hale

Views: 0
July 27, 2022
Women And Self-Confidence – Healing Women's Insecurity Issues Today

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Sound like a latte-in-the-sky dream? I mean the kind that could never happen in this lifetime?

Today, all that ends.

Let some new confidence with women understanding begin inside you, and beautiful begin being who you are to the core.

This program for women and self-confidence is exactly the kind of community of women friends you should meet. Its specialty is helping women exactly like you.

Heal those old wounds so you can break free from the past.

Stop feeling insecure and overwhelmed by other people's demands.

Pick up those shattered pieces of women's insecurity issues sitting around in your soul, heart and life and build something stunning and gorgeous with them.

It's like the Course in Miracles states, "Do not be afraid to look within you."

If you keep on beating yourself up OR ignoring it and hoping it will all solve itself, you can't pull yourself together.

Unleash the confident, Got-It-Together, GORGEOUS and RADIANT woman you were MEANT to BE.

There is nothing that feels better than having the total life confidence needed to be your real, luminous self.

It makes a woman undeniably gorgeous, and you don't have to be a super model here to be a confident woman.

It is life miracles of the highest order, and you deserve lots and lots of that!

Get YOUR life miraculously going again!

In a previous session I discussed other topics like how to realize more beauty and experience healthy weight loss without paying a fortune for a weight loss program.

And, imagine being able to turn the heads of men (AND women) as you walk into a room, radiating COMPLETE confidence and allowing your inner goddess to glow.

What if I told you that the universe is waiting to give you OCEANS of love?

Wave after wave of it!

A drenching, nourishing, sea of it!

You've built an emotional sea-wall that won't let it get to you, and here's the Truth:

Spark some sizzling hot romance EVEN if your relationship is flat-out boring right now (It takes mere SECONDS to put this to work for you …).

When you feel loved and confident

Don't deny your beautiful heart any longer. Unleash the miracle power of love in your life!

Yes, you can indeed change your love life and everything else, from PESSIMISTIC to PASSIONATE in a heartbeat.

You have what it takes to feel the POWER to go after your dreams, and you naturally ATTRACT the man of your dreams.

And if you're already in a relationship, you can build the kind of life together that most people only dream of.

Dating and relationships are so much easier (and fun!) Once you FINALLY start accepting love.

When you can FINALLY allow for to be given you love unapologetically from the world that's when your life and your relationships start to miraculously transform and you release all those women's insecurity issues.

Extend your inner beauty!

Begin right now in this instant to EFFORTLESSLY accept every kind of good and beautiful love into your life.

When women's insecurity issues have your life split apart in pieces all over the place, it's easy to feel defeated.

When frustration hooks up with unworthiness and they have a child called I AM SO TERRIBLY OVERWHELMED, confidence with women is difficult.

You know what I mean?

Wouldn't it be nice if you could let go of women's insecurity issues and get the JOY and BEAUTY of a woman who has her act together, as easily as ordering a latte with your BFF at your favorite coffee shop?

(Please note I always suggest searching the net for related material on how a woman with no dreams for the future can TODAY become a stronger confident woman.)

To your inner beauty shining forth!

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Source by James Nussbaumer

Views: 0

July 26, 2022
How Should The Other Woman Proceed When The Wife Finds Out About The Affair?

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I sometimes hear from women who have been cheating with someone who is married. Some of the time, they truly believed that in due time, the man’s marriage was going to come to a natural and mutual end so that the two of them could be together. They wanted to believe that the marriage had grown stale so that both people would mutually agree to end the marriage. Once this happens, then that would free up the husband to pursue a new relationship.

As we all know, this isn’t usually the way that it happens. Usually, the wife finds out about the affair and the marriage does not just end by both people mutually agreeing to it in a healthy way. The wife is usually hurt and angry and, believe it or not, the husband usually panics and immediately chases after his wife, suddenly afraid that he’s going to lose his family.

Understandably, this can leave the other woman confused. This isn’t how things were presented to her. And where is she in all of this? You can see how she would feel left out in the cold and unsure about how to proceed. She might say: “I feel stupid admitting that I honestly thought I was going to live happily ever after with the man that I was dating. I knew that he was married, but he presented it to me like he was working on untangling himself from that. Still, he was always careful that his wife would not find out. But she did. And I was shocked when he immediately told me that he could not see me anymore and begged me not to make this harder than it already was. I’m very shocked by this. And I feel set aside and hurt. Now this guy and his wife are scrambling to save their family, but what about me? I feel like I need to do something. I feel like I am left out in the cold of all of this. I am tempted to try to contact his wife and plead my case. I want her to know that the husband represented to me that their marriage was over. I want for her to have all of the information so that she doesn’t think that her husband is loyal to her. And I want to see the other man and plead my case also. After all that we have been through, it is annoying that he is just going to walk away. What should I do right now?”

Honestly, I am not sure that you are going to like my answer but it is heartfelt and is what I honestly feel and believe. I will admit that I have been the wife in this situation, but I’ve had friends in your situation and I hear from many on the other side of the equation. I can tell you that statistically, the husband and wife generally end up together. It may take a while. And there can definitely be some uncertainty, but statistics show us that it is much more likely for the husband to go back to his wife than to have a lasting relationship with the other person. You can check this for yourself, but that is what the statistics show. That is why I do not recommend that you reach out to either of them. It is only going to hurt, annoy, and frustrate everyone involved and the chances are high that it is not going to affect the outcome in the long run. You’ll only be causing pain to yourself, the husband, and the wife.

I know that a big driving force for you right now is that you feel set aside and ignored. One reason for this is that it feels as if your course of action is set by someone else. Since the husband and wife have the marriage, they get to decide how things proceed, which can seem very unfair. So how do you get a sense of control back? By bowing out gracefully from this trio and focusing on yourself, your own well being, and your own happiness. Take control back of your own life. Ask yourself why you’d be vulnerable to settling for a man who couldn’t be solely yours. Fix your self esteem and then vow to only give your heart to men that are free to return your love and be yours alone. All women deserve nothing less. I know that this might not be what you wanted to hear, but I believe that it is the healthiest option. It gives you control of your life, it really is the right thing to do for all involved, and it doesn’t force you to go against the odds. Trying to hurt others usually ends up only hurting you. There’s more than enough hurt to go around right now, so you can never go wrong with focusing on your own healing instead.

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Source by Katie Lersch

Views: 0

July 26, 2022
Am I Ordained To Marry?

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One common question people ask us during counseling is whether they are ordained to marry or not. Few weeks ago, a sister walked up to me to ask if she was ordained to marry or not. I asked why she thought so. She said, her pastor taught them that it is written in Matthew 19:12 that some people were made to be eunuchs and therefore, not everyone is expected to marry. And now she was worried because of the series of disappointments she had experienced in her relationships. When I asked her whether they were equally taught how to differentiate between both groups she said that was why she came to ask me. I said she should have gone to her pastor to ask but she said she would not because they were more interested in how many souls they had won to Christ than their marital plans.

Her vehement refusal to go to her pastor for counsel was a clear indication that she had gone through some elements of frustration. I don’t know how many people are in the same situation today. All I know is that someone will be free from this bondage today.

Before I address the core issue, let me tell you that Christianity is a balanced relationship. The same God that says he that wins a soul is wise also says marriage should be honored by all, and the marriage bed kept pure, for God will judge the adulterer and all the sexually immoral, (Hebrew 13:4 NIV). The practice of holding back mature adults in church from marriage because you don’t want to lose them to other churches or distract them from actively engaging in church growth is unbalanced and unhealthy for the growth you desire. Marriage is an honor before God. It brings glory to God. Anyone that desires to marry should be encouraged before they begin to defy themselves right under your pulpit.

My counsel is that while encouraging them to continue winning souls they should also be counseled on the right way to find the right kind of spouse and the right way to marry. Teach them to let their marriage become a plus to the church instead of minus. If you alone could chase one thousand souls, let you and your spouse join in marriage to chase after ten thousand souls.

Matthew 19:12 says: ” For there are some eunuchs, who were so born from their mother’s womb: and there are some eunuchs, who were made eunuchs of men; and there are eunuchs, who have made themselves eunuchs for the kingdom of heaven’s sake. He that is able to receive it let him receive it.”

The above scripture clearly defines the three categories of eunuchs. Our point of emphasis here shall be on those born eunuchs from their mothers’ womb. The other two are those forced into it and those that became so by their choice.

When God created man in His image and likeness, He decreed that he should go into the world and multiply. That declaration is for you and me. The only approved way to achieve this multiplication is to marry legally and keep the matrimonial bed holy. You don’t need an angel to whisper into your ears that it is time to marry. The rules are there in the bible. That is not our focus for today anyway.

Take example from Abraham, the father of faith. He didn’t need any prophecy to discern whether his son Isaac, needed a wife or not. All he needed was simple wisdom drawn from the Word of God. God told him during his call that through him the earth shall be populated with His new generation of children. He settled it in his mind to get a wife for Isaac to make that calling and purpose come to fruition. At the appointed time, he sent his servant, Eleazar to go to his kindred to get a wife for Isaac. You know the rest of the story in Genesis chapter twenty-four.

God designed man with all the features required to perform all that He wants him to do on earth in the same way a manufacturer will not put his products in the market place without the inbuilt features to function. Signs of puberty, sexual emotions and strong attraction towards the opposite sex are some indicators that you are ordained to marry. When His due season is near, He begins to impress His desires in your spirit for onward transmission to these dormant sexual potentials in you and suddenly you will awaken to certain pressure in that direction. The bible says, ” it is God who works in us both to will and to do of his good pleasure”, Philippians 2:13. Marriage is one of the good things that bring pleasure to God. When you start feeling the urge or willingness to get married just know God has begun this good work in you. Anybody that has this urge or desire to marry is one of those God has ordained to marry. Period!

To become a eunuch or to marry is your choice. God has given you the free will to decide it. He will not choose or impose any one on you. Apostle Paul chose not to marry because he wanted to use his life to serve God and not because God said he should not. His case should not become a doctrine to dissuade people from fulfilling God’s purpose for their lives. He even admonished anyone that is unable to bear it to marry instead of burning in lust. If you choose to live a life of celibacy or choose to marry as you have desired, God is pleased with you. Do not allow previous disappointments dissuade you or make you start thinking that it might be that you are among the chosen eunuchs. You are ordained! If things are not working well, find out what you have not been doing right, keep correcting and working on yourself so God can connect you with the right kind of spouse.

However, it does not mean you should rush into anyone because God has willed it so for you. There is period to find the right kind of spouse and there is time for preparation. My stake here is to let you know that these signs put you in the category God has ordained to marry. You do belong to the group of those made eunuchs from their mother’s womb.

Parents should watch out for these signs in their children and wards. When these signs begin to show up, it is a signal to parents to start preparing their children or wards for the next phase of their lives. Unfortunately, many parents and guardians around these children do not always prepare them on time, and sometimes they misdirect them through wrong information. We owe the upcoming generation this responsibility as guardians. Those who fail at this level of parenting always regret it because late stitches steal real good time.

Those made eunuchs from their mother’s womb do not have and will never have the urge to get married because they do not have the features in them. I do not mean those incapacitated by sickness, diseases and infirmities like down syndromes, depression or paralysis. These are healthy and virile folks who are repugnant to the site of the opposite sex. They never have any amorous feelings towards the opposite sex even when they are both nude in a secret room.

Whether we choose to marry, remain single or born incapacitated, it does not make us sinners or better before God. He loves all of us equally, but it will please Him to see us fulfill His desires for us. I have cleared the obstacles before you. The onus is now on you to decide what you want. Apostle Paul chose not to marry because it was his choice. Apostle Peter did not divorce his wife because of God’s work, yet God accepted them all. Decide your case by yourself.

Remain Blessed!

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Source by Christopher UI Ogholoh

Views: 0

July 25, 2022
The Secrets of Juicing: How To Heal Your Organs

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Do you ever feel like you want to eat more vegetables, but don’t know how to incorporate them in your diet? Well, juicing is the answer, people. Juicing is a great way to add a boatload of nutrients to your diet in a quick and efficient way. Drinking freshly made raw juice can help give your body extra fuel and a healthy boost.

Making the jump to juicing is an investment. We are going to let you in a secret, though. If you don’t want to buy a juicer, you can make fresh smoothies and get the same benefits (plus a bunch of dietary fiber) by blending all of the ingredients. But if you’re the kind of person that likes a smooth and light juice, go ahead and get a juicer.

Let’s be clear: juicing is not the only way to stay healthy. It also doesn’t balance out the junk food or processed foods you eat. Juicing is just a great way to channel your life in a healthy direction. Considering that most health officials say that it is good to get about 6-8 servings of fruits and vegetables every day, juicing can almost guarantee you those servings.

There are some awesome benefits of juicing, the number one being that it can help to nourish and heal your organs. Different vegetables contain vitamins and minerals that can be beneficial for your heart, lungs, kidneys, liver, and your skin. These organs are vital in carrying out your body’s primary functions. If one or more of your organs is functioning improperly, your body will suffer. This is where juicing or cleansing can come to save the day.

Not everyone is aware of all the benefits of every fruit and vegetable. It’s pretty hard to retain all that info. So we’ve decided to give you a few juice recipes that’ll help out your major organs, because they deserve all the help they can get. All you have to do is process the ingredients in a juicer and drink the juice. It’s that easy.

Heart Health Juice: 1 Apple, 1 Beet, 6 carrots, ½ Lemon (peeled), and 2 Oranges (peeled).

This juice is packed with vitamin C, which helps nourish tissues and build cells.

The Eye Opener: 2 Apples, 10 Carrots, and 2 Oranges (peeled).

Quick Tip: when you make this juice, or any juice, you can use fruits and veggies that are about to spoil, so you don’t waste them.

The Best Juice for Your Liver: 2 Beets, 2 Carrots, 2 Celery Stalks, 4 handfuls of Parsley, 1 Jalapeño, 6 Radishes, and 4 Plum Tomatoes.

This juice has a little kick from the radish and pepper, but it helps your liver flush toxins out of your body.

Summer Breeze: 4 fresh Basil leaves, 1.5 cups Blueberries, 2 pinches Cayenne Pepper, ½ Lime (peeled), and 5 cups Watermelon (diced).

This juice has all the best flavors of summer. Here’s a secret, the watermelon rind is great for smoothing out roughage in your colon.

Skin So Health: 3 fresh Basil leaves, 10 Carrots, ½ Lemon (peeled), and 4 Peaches.

This juice helps rejuvenate your skin. Add a little organic coconut oil to the juice for an added benefit.

When you are juicing, you can always add water because that’ll help your digestion, speed up your metabolism, and give your cells some extra fuel. Share some of your favorite juice recipes with us and don’t be afraid to get a little creative.

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Source by Vinnie Stevens

Views: 0

July 25, 2022
Telecommuting: How It Supports A Green Lifestyle

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These days people are more interested in saving time energy, and ways to make their lives easier and more productive all at once.Our world is changing fast and sometimes it is hard to keep up.

Being a Baby boomer in a world filled with so many technical challenges to learn and keep up with can be a little intimidating. It is important though to familiarize yourself and try to keep up to date with how to stay connected without losing yourself in the mix. But working from home has improved my overall attitude about work, and has helped me to be more productive, and creative while at the same time helping to do my part in working towards a Greener way of living.

How I am benefiting from working at home

First I am saving money on gas every week! And although the price of gas has gone down, I am taking that money that I saved, and putting it towards investing in my business. I choose my own hours to work and by working in blocks of time, I can manage to get many things accomplished in an allotted amount of time, and also take breaks and a walk or do some yoga stretches in between.

Eating a healthy meal through the day is important to me being vegan, and health conscious of what I am feeding my body as well as my mind. I can eat at leisure setting a block of time, just for eating as well as for breaks and I still get everything accomplished in an efficient and timely manner. Still being professional and at the same time taking good care of myself, so I can work at my optimum best.

Telecommuting can ease the stress of having to commute back and forth to work in bad weather. It will definitely save some wear and tear on your vehicle and tires and save the time it would take to get back and forth from work. It can also save you money on dry cleaning costs!

Another great reason to work from home and help support a green lifestyle, because dry cleaning uses Perchloroethylene, a toxic chemical that is very harmful to our environment, and if you are concerned with helping reduce toxins you can look up where to find a green dry cleaner in your area instead.

Working from home enables you to work for longer periods and more comfortably by being in surroundings that are stress-free and conducive to your overall benefit. Create a workspace free of clutter. Make sure you have some water to keep hydrated. Have all of the tools and implements you may need close by to help you work efficiently, and so you do not have to keep getting up and down. Turn off all distractions unless some soft music in the background helps. And enjoy creating those masterpieces!

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Source by Debbie Frye

Views: 0

July 25, 2022
Can You Cure Foot Pain, Back Pain and Fatigue With Shoe Inserts?

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I’m always on my feet it seems like. I have a job that is pretty demanding, walking and standing on my feet, eight hours a day. Some days I walk five to seven miles. I know, there are plenty of other jobs out there that are way more demanding than mine. However, doing a job like mine in dress shoes or any low-quality shoe can kill your feet. And this can lead to significant foot pain, back pain and worse. It can knock your quality of life down a few notches, and that’s precisely what it did to me.

With foot pain came back pain, exhaustion and me having to cancel my workout routine.

I mean, it wasn’t too long ago, I’d spend eight hours a day, working on my feet, before coming home and having to soak in the tub with Epsom salts. It was the only relief I could find. All of the pain and discomfort was rooted in the shoes I was wearing. They were nice looking, but not pleasant to walk around in all day.

Eventually, thinking I was going to have to quit my job (I did before going back.), I asked around and found out about some top of the line shoe inserts. I also bought new shoes.

With the new shoes, I felt 100 times better being on my feet. It was unreal. However, the shoe inserts made the most significant difference in my life. With top of the line shoe inserts, I could literally walk all day and have zero issues. I mean, after work, I felt zero pain and had no issues with my feet or back. Not only was there no pain, but no exhaustion either. After work, I still had plenty of energy and could go to the gym without any problem. It was amazing.

The best thing is that I can use the same inserts in all of my different shoes and enjoy the same benefits.

I never would have guessed that such a simple change could make so much of a difference in my life.

If you suffer from foot pain, back pain and your quality of life is suffering simply because of being on your feet, I highly suggest trying a pair of high-quality shoe inserts. They could change your life.

Additionally, regular exercise, weight-training and a healthy diet might help you, too. Being physically fit can make certain types of labor easier on your body. However, always check with your doctor before starting any new workout routine and diet.

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Source by Elvis Jackson Jr.

Views: 0

July 25, 2022
How Excessive Exercise Might Negatively Affect Your Health

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A great deal of people engage in cardiovascular and several other activities primarily in order to lose weight. Then again, carrying out excessive workouts of any kind could cause the body to begin reacting in a negative way. This brings to memory the proverb that says – too much of anything is bad. And workout is no exception here.

Training is a great thing and it would appear that training even more ought to provide a lot more benefits. In the truest sense, it really does give a little extra gains, until it is taken just a little bit too far. At this juncture, your body may start responding otherwise.

This is correct besides the fact that training is acknowledged to be more of a “healthy stress.” However, your adrenal glands are unable make a distinction between them.

Stress and Cortisol

Excessive physical exercise induces a hormone called cortisol. This hormone tells your body to hang onto its fat stores. The body secretes cortisol anytime it is under any sort of tension.

The stress might be from the school, place of work, unhealthy eating, too little sleep, family issues, and a number of other things. They can easily stress your body and cause it to release cortisol. The regrettable thing is that the body also looks at physical fitness as a stressor.

Consequence of Excessive Physical Exercise

If you push the body way too hard for a long time it may result in higher cortisol levels, adrenal fatigue, and even elevated food cravings.

Stress, regardless of its source, has a way of influencing neurotransmitters. These neurotransmitters, including dopamine, GABA, and serotonin, are our feel-good, anti-anxiety brain chemicals. Stress and excessive extreme training reduces the quantities of these types of neurotransmitters. This usually brings about debilitating weariness, sleep disorders and also depressive disorders.

Continually high amounts of cortisol may have detrimental impact on fat loss. It could also raise your associated risk of a range of health issues.

Female Athlete Triad

For the women, excessive physical exercise can equally result in the “female athlete triad”. This is a condition of, the likely stoppage of her menstruation, eating problems, and brittle bones or bone mineral loss. A mixture of workout and calorie restriction typically leads to these kinds of symptoms.

Decreased Immune Effectiveness

Moderate physical fitness helps to enhance your body’s immune system whereas too much physical exercise tends to suppress it. Excessive workout raises the body’s exposure to infections. Likewise, there is the elevated seriousness of minor infections and also the decreased production of immunoglobulins.

Decrease of Testosterone

Also, it is a reality that cortisol and testosterone clash with each other. Testosterone is important for the development and preservation of skeletal muscle, bone, and red blood cells. They equally assist in weight reduction as they are very metabolically active.

Workout depth (which is over 50% of maximal oxygen intake) of extended period sets off the sympathetic nervous system and results in cortisol overproduction. On the flip side, this stops the discharge of testosterone.

The reduced testosterone, for males, could easily cause decrease in libido. This might however be a combined consequence of both bodily exhaustion as well as the reduced testosterone levels.

In the event that you have been working out too much, the very first course of action is for you to truthfully recognize and acknowledge this reality. You have to admit to yourself that you are really struggling with this problem.

One other idea that may assist you to cut back on the amount of your training routines will be to stick to a training schedule. This schedule should vary your exercise load and equally incorporate obligatory rest periods.

Nevertheless, it will be necessary to seek help from a healthcare professional for the treatment of both the psychological and physical symptoms.

On the other hand, this is not suggesting that you should give up on performing exercises but rather that you have to get the right amount.

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Source by Marcus J Michael

Views: 0

July 25, 2022
Breathing To Heal – How Yoga Helps Arthritis

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Arthritis is common but not well understood. It is not a single disease but a way of referring to joint pain or joint disease. There are more than 100 different versions of arthritis and related conditions. People of all ages suffer from this malady, and it is the leading cause of disability in America. According to the Arthritis Foundation, more than 50 million adults and 300,000 children have some type of arthritis. It is most common among women and occurs more frequently as people get older.

Common symptoms include joint swelling, pain, stiffness and decreased range of motion. Symptoms may come and go or stay the same for years. They can be mild, moderate or severe but may progress or get worse over time. Severe arthritis can result in chronic pain and an inability to do daily activities. It can cause permanent joint changes which may be visible, such as knobby finger joints, but often the damage can only be seen on an X-ray. Some types of arthritis also affect the heart, eyes, lungs, kidneys and skin as well as the joints.

Yoga is a set of practices with origins in ancient India. The word yoga comes from a Sanskrit work meaning "to yoke" or "to unite." It focuses on unifying the mind, body, and spirit, and fostering a greater feeling connection between the individual and his / her surroundings. Its main goal is helping individuals realize balance. Beyond this, yoga has several secondary goals, such as improving physical health and enhancing mental well-being and emotional strength.

In addition, yoga is associated with increased mental energy as well as positive feelings (such as alertness and enthusiasm), fewer negative feelings (reduced excitability, anxiety, aggressiveness) and sleep issues. In summary, yoga is associated with a wide range of physical and psychological benefits that may be especially helpful for persons living with a chronic illness such as arthritis.

As with any physical activity, it is important to take proper precautions such as checking to see that a doctor hasn't placed any limitations or restrictions on an arthritis patient. If a medical professional has specific concerns, get them in writing and give this information to the yoga instructor. A qualified yoga teacher generally starts a beginner with a gentle, therapeutic class. It is important that the class is led by an instructor who can guide one through safe and healthy poses.

Wear comfortable clothing that allows for full movement of the body. If it is too loose, the instructor will be less able to guide proper alignment but it should also not be restrictive. Clothing specially designed for yoga is available, but unnecessary. Yoga is traditionally practiced barefoot, though it may be possible to wear socks at the start of class, until the body warms up. Mats are used in modern yoga practice to provide cushioning and prevent slipping. Some studios supply mats for general use.

The general rule for arthritis patient is that if it hurts, stop. The old adage of "no pain, no gain" does not apply to yoga. When doing certain poses, arthritis patients should keep them relatively small and be aware not to hyper-extend the neck, keeping the head in line with the rest of the spine. For those with arthritis of the hip, be cautious when doing "hip openers" or poses with extreme external rotation of the hips.

Generally, there will be pain if one is going too far with a pose, but sometimes the effects are not felt until the next day. It is important to start slowly and expand the practice as the body dictates.

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Source by Sherry Lynn Daniel

Views: 0

July 25, 2022