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What Is Regenerative Medicine?

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When Adrienne Shapiro’s daughter Marissa was diagnosed with sickle cell disease, the doctors said that she would not live till her first birthday. However, when Marissa managed to live past that benchmark, it did not mean the end of Adrienne’s worries. In fact, it was the beginning of many painful years of blood transfusions and immunological disorders. When an improperly matched blood transfusion caused a severe reaction leading to the removal of Marissa’s gall bladder and temporary kidney failure, she was unable to receive further blood transfusions.

However, luckily for Marissa a project sponsored by the California Institute for Regenerative Medicine (CIRM), headed by Don Kohn, MD at UCLA, was starting a clinical trial. The objective of the project was ‘to remove bone marrow from the patient and fix the genetic defect in the blood-forming stem cells. Then those cells can be reintroduced into the patient to create a new, healthy blood system.’The success of this clinical trial has given hope to Adrienne that with the help regenerative medicine her daughter will be able to lead a healthy and pain-free life.

The Stem Cell & Regenerative Medicine Center at the University of Wisconsin-Madison describes ‘Regenerative Medicine’ as ‘a new scientific and medical discipline focused on harnessing the power of stem cells and the body’s own regenerative capabilities to restore function to damaged cells, tissues and organs.’

Stem cells that are found in the umbilical cord blood of new born children have the ability to renew and regenerate themselves. A stem cell, through the process of mitosis, can divide itself to either become a specialized cell like a brain cell or muscle cell, or remain a stem cell. They are also able to repair internal damage caused by any type of disease, disorder or trauma. Stem cell transplantation, stem cell grafting and regenerative medicine are some of the ways in which these cells are used to cure disorders and illnesses.

Regenerative medicine includes a wide range of scientific disciplines, such as biochemistry, genetics, molecular biology and immunology. Scientists from these fields have been conducting research and studies in this domain and have identified three methods of using regenerative medicine. They are cellular therapies, tissue engineering and medical devices and artificial organs.

Cellular Therapies – In this method, cellular materials, in most cases adult stem cells, are extracted and stored and then injected into the site of injury, tissue damage or disease. These cells, thereafter, repair the damaged cells or regenerate new cells to replace the damaged ones.

Tissue Engineering – This method is related to the field of biomaterials development and utilizes a combination of functioning tissues, cells and scaffolds to engineer a fully functioning organ which is then implanted into the body of the receiver in place of a damaged organ or tissue.

Medical Devices and Artificial Organs – When a body organ fails, the most common method of treatment is to replace it with a donor organ. Donor organs are not easily available and can pose as a hindrance in such cases. Even if a donor is available, he or she may need to take immunosuppressant drugs before the transplant and these drugs have been known to cause side-effects. In such circumstances, medical devices that imitate the function of the failed organ can be used, instead of transplantation. An example of one such device is the ventricular assist device (VAD) that is used in place of heart transplants.

Since regenerative medicine deals with the use of stem cells, it occasionally requires embryonic stem cells for research purposes. This use of embryonic stem cells can often give rise to questions regarding ethics and legality. The laws and regulations concerning regenerative medicine are different in different countries. Creation of human embryos for research is only legally permitted in three countries. Majority of the countries only allow extraction of cells from surplus IVF embryos. A recent study, related to human embryonic stem cells (hECS) research policy, was conducted which revealed that UK, Sweden and Belgium were very permissive in authorizing the creation of human embryos for research, whereas, Luxembourg, Austria, Poland and Ireland had no laws regarding hECS. The legislations regarding hESC in most other countries range between being mildly restrictive to very restrictive.

Regenerative medicine is the future of modern medical treatments. Scientists are conducting clinical trials and studies every day to further enhance and improve in this area of medicine.

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Source by Richa Verma

Views: 0

October 8, 2019
Unbiased Renegade Network Marketer Review

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Renegade Network Marketer was written by someone who has been in and out of the MLM industry for nearly 20 years – Ann Sieg.

She started out in the old days of cold calling, bothering friends and family and inviting disinterested people to hotel meetings and into her own home.

Twenty years ago we didn’t have the internet, and everything has changed in the MLM industry since it came along.

It really is nice to find a course written by someone who has been in the business that long and isn’t afraid to admit that she nearly gave up on many occasions. Too often these kinds of courses are written by young men that are barely out of high school, hoping to impress people with scantily clad models spread out over a rented Ferrari. Ann’s book is nothing like that, if you are already saying “oh not another one”.

Renegade Network Marketer Review – The Pros

This course is different. It has been painstakingly written by someone who knows and has been through all the pitfalls of internet marketing and who tried every method known to man to become successful in MLM.

The Renegade Network Marketer review was written after she nearly gave up again but after she had one of those “Aha” moments.

There was nothing wrong with network/MLM business marketing model, it was how marketing was being taught that was at the root of most network marketer’s problems. It was the methods not the business.

So she set out to write this comprehensive course after realizing why network marketing was so frustrating and difficult. The number one problem was how to get the prospect to come to you, instead of you going after them! Now that was revolutionary! It is so ridiculously obvious.

When you do that the playing field becomes a much friendlier place, you never get rejected or fobbed off with excuses ever again. Your social life and your friends want to be around you again, because you don’t have to try and sell them on your latest and greatest opportunity. You go from defensive to offensive, negative to positive and it’s amazing how empowering a thriving business can be. You can’t wait to get out of bed in the morning!

The Renegade Marketer review has the tools and insight to help grow any network marketing business. It will help you generate leads and the tools to take you as far as you want to go with your business.

The Renegade Network Marketer, deservedly, gets many positive reviews from people who have gone from debt and depression to positive cashflow and success.

If you want a truly amazing system that will cram your funnel full of high quality prospects, take a look at the Renegade Network Marketer.

The Renegade Network Marketer contains a 143 page in-depth, manual that details the same formula the writer used to build her successful businesses bringing not streams, but floods of income.

Renegade Network Marketer is a must for anyone who wants to take a giant leap with their network marketing business.

Renegade Network Marketer Review – The Cons

Ann Sieg’s program is great. You will LEARN a lot. But you will still find yourself without a viable “process” or online marketing “system” to produces the results you need to grow your business.

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Source by Rob Fore

Views: 0

October 8, 2019
Entrepreneurship Knowledge Services

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When an entrepreneur is starting a business he or she is faced with the requirement of several functions in which they might not be experts. They may know, for example, all there is to know about wholesale distribution but have no idea how to build a website.

Since most companies are started with very limited funds, many entrepreneurs are reluctant to set money aside to pay for consulting services to fill in their knowledge gaps. For example, many create a website from the many templates available. Some are even free.

Where the company website is concerned I feel that the use of existing templates is a false economy. The website functions as an online calling card and needs to put your best foot forward. For site visitors, seeing a format that they have seen before can reflect badly on you.

The amount of time required for the entrepreneur to become proficient enough to develop a quality website takes time away from tending to functions relating to product knowledge, operations and management. Contracting with a website development company could be the solution.

Websites, to be noticed, must go through the Search Engine Optimization (SEO) process. The purpose of SEO is to improve your website’s chances of ranking high in a search. The mechanism for doing this is complex and dynamic. This again is a very specialized function that is often beyond the capability of the business owner.

There are functions which may be grouped under the heading Entrepreneurship Knowledge Services that will present the company at its best. In addition to the website and SEO examples these can include Business Strategy Planning and Business Valuation Services.

Entrepreneurship Knowledge Services is a rich term covering what one needs to know to be a successful entrepreneur. There are other issues to be considered besides knowledge however. Do you have the right temperament? Do you have enough tolerance for risk? Can you acquire the funds to be a success?

My recent experience is that the cost of business services for the self-employed is going down. One of the reasons is the quality and economy of services from Indian consultants. My experience with two firms in India has been positive. This is simply my experience, and yours can be vastly different, but I got a substantial amount of website design for about $4,000 and SEO for about $2,000.

Your reaction may be that adding $6,000 to your startup expenses is prohibitive, but by farming this out the entrepreneur should find a quicker path to profitability.

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Source by John Vinturella

Views: 0

October 8, 2019
Smart Entrepreneurs Wear Six Hats
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Entrepreneurs are necessarily optimistic. You need to be, it allows you to see the possibilities around you and act on them.

However, the downside is that your emotional attachment can blind you to problems that are otherwise obvious to someone who is not as personally invested in the project.

This is why smart entrepreneurs learn to wear six hats: six "Thinking Hats". Originally defined by psychologist Edward DeBono, the Six Thinking Hats are a structured creativity tool to help you look at a situation from different perspectives, to solve a problem or to foresee and minimize risks before they turn into problems.

When you "wear" a specific color hat, it gives you permission to look at your problem is a specific way:
- White Hat: Analytical – What does the data say? Look at the available data, both quantitative and qualitative. What are past trends? What can you extrapolate? Where is the evidence to support your assumptions? Where do you need more data?
- Red Hat: Emotional – How do you feel about this? Access your intuition, gut reaction, emotion. Talk about your feelings about the situation, where you feel good and not as good. How would others feel about this?
- Black Hat: Pessimist – What could go wrong? Think cautiously, defensively, why it might not work. Poke holes in the idea, look for the weak spots, all with the intention to identify what needs to be addressed in order to overcome any problems.
- Yellow Hat: Optimist – What if all goes right? Think optimistically, positively. Imagine all the opportunities, the benefits, the advantages. Reach for the stars!
- Green Hat: Creative – How can we make this better? Use your creative juices to think "out of the box". Explore weird tangents, unexpected synergies, make it into a "purple cow" (something remarkable that stands out from the crowd).
- Blue Hat: Process – What do we need to do now? Direct the process of creativity so avoid getting stuck. When in "Blue Hat" mode, step back from the problem and consider if you are giving all of the other hats equal time.
Entrepreneurs seem to do quite well with the Yellow, Red and Green Hat approaches to thinking about an idea. There is more resistance to the White Hat (analytical) and definitely a big block around Black Hat thinking. Could this be because the Analytical and Pessimist are associated with external control?

There is nothing to fear from the Black Hat – it can be your best friend. Wearing the Black Hat gets you out of cheerleader mode and forces you to examine your assumptions up close. From personal experience, I know that when a project backfires, the failure can be traced back to an assumption that was not properly tested. Black Hat thinking gives your project real traction by foreseeing the difficulties and encouraging defensive planning. This makes the plan more resilient and improves the probability of success.

As you explore wearing the various Hats, put on the Blue Hat (Process) from time to time to see if you are considering all the perspectives of your project. Note that the purpose of this thinking exercise is not to assign fault or blame. The mindset of every Hat is to make sure the project succeeds.

It is great fun to dream big and to reach for the stars. But if you want to make any progress, you need to keep your feet on the ground. Practice wearing the Six Thinking Hats as you plan and execute your business project. This mindset will give you the traction to power your project towards real and enduring results.

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Source by Davender Gupta

Views: 0
October 7, 2019
My Husband Says He’s Going To Leave Me, And Yet He’s Still In Our Home – Why?

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Often, when a husband announces that he is going to leave, a wife expects him to promptly pack his bags and begin the separation. It’s not that this is what the wife wants to happen. But when someone makes an announcement that is this serious, well, the assumption is that no one would want to drag their feet on this, as once the decision has been made, it’s probably easier to just go ahead and move out.

However, this isn’t what always happens. Some husbands make this announcement and then they don’t really move out right away. Some are still telling their wives that they are leaving even as they continue to park themselves on the couch and make use of the refrigerator. A wife might say: “I truly don’t get it. Three weeks ago, my husband came home and announced that he is going to leave me. He said that our marriage hasn’t been good for a while now and that he thinks that we should take a break and live apart to see what happens. This isn’t what I want. In my heart, I feel like if he leaves, he might never come back and we might end up divorced. He actually told me that he wanted to leave on a Friday night. I expected him to move out that weekend. Why wait? If you’re going to take the initiative to tell your wife that you are going to leave her, I would think that you would want to leave as soon as possible. That isn’t the case, though. It’s three weeks later and he’s still in our house. He’s still complaining. He’s still saying he’s going to leave and yet he is still here. I’m afraid to ask him why he’s still here because I am afraid that he would take that to mean that I wanted him out. My mom says that he is essentially free loading or that he’s too lazy to find a new place, but that doesn’t make sense, as my husband earns more than I do. Why do men say that they want to leave their wives and then stay at home?”

I can only speculate, because there are a variety of reasons. I will list some of them below so that you can see if any of them might ring true.

He May Not Want To Actually Leave And Was Just Trying To Get A Reaction: Sometimes, a husband truly is frustrated with the marriage or the situation, but he doesn’t know how to create change. He may have tried to make a change without success or he’s afraid that you will be resistant or defensive. So he puts the “leaving” out there in the hopes that you will try to stop him or that you will then be open to negotiating change.

He May Be Trying To Move Out At The Right Time Or In The Right Way: Some husbands do take their time in actually moving out. Many aren’t all that excited about moving from their familiar and comfortable home into a smaller apartment. Others will try to leave their wife in a good place before they physically move out. What I mean by that is that some will complete repairs and necessary maintenance before they leave so that their wife doesn’t have to worry about this.

He May Be Having Second Thoughts: This is the final suggestion that I will make. We all say things or make decisions out of frustration, only to have second thoughts later. Actually moving out of your home and pursuing a marital separation is a huge step. And it would be completely normal for him to reconsider and then to hesitate to admit this. It’s possible that he’s hoping that this will just blow over or that you will ask him not to leave.

Deciding Where To Go From Here: Since you can’t know which of the above is true (unless he tells you,) then you have to ask yourself what really matters the most. If you want to save your marriage, then I think you have focus on the fact that at least he’s still there – whatever the reason. It’s so much easier to save your marriage when your husband is physically present. When he moves out, it can be difficult to reconnect and to not have repeated misunderstandings since communication is limited and not always face-to-face. Yes, I know that it is frustrating that he’s sending mixed signals and that this is confusing. But I think that it is better to focus on the fact that he is there rather than questioning him and then potentially forcing him out. If you can use this time to improve things so that he doesn’t follow through and leave, then that’s probably the best option.

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Source by Leslie Cane

Views: 0

October 7, 2019
Four Essential Solutions To Heal From Your Profound Sorrow – Stop Grieving And Start Healing

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Grieving And Start Healing

1- Optimism!

"The first step towards the solution of any problem is optimism." ~ John Baines

Begin by thinking and believing you can take one step toward hope and peace no matter how overwhelmingly complex it may appear. Keep your candle of hope lighted even though your circumstance may seem fogged with blackness.
"It is better to light a candle than to curse the darkness."
~ Chinese proverb often quoted by Eleanor Roosevelt

The darkness of your cave of sorrow clouds and grief shadows can seem overpowering. Yet, unknown, unexplored possibilities can be discovered, explored and applied in your healing. Opportunities and potentialities of hope can be illuminated by your small candle light of anticipation and optimism. Even in the darkest of conditions happiness can be found. You must remember to turn on your light of hope.

"It is during our darkest moments that we must focus to see the light."
– Aristotle Onassis

Optimism can help you focus on undiscovered possibilities. Focusing on opportunities not yet considered with hopefulness and confidence is vital to stop grieving and start healing. Optimism is your first important solution to overcoming your sorrow.

2- There are Answers

"Be thankful that life is a mystery. There is so much we can never know. Breathe deeply and relax into the not-knowing. There is much that we do not have to know in order to live joyfully."
~ Jonathan Lockwood Huie

Seeking all the answers to heal from your deep grief experience may not be in your best interest. Every answer to the "Why", "How", "When", and "Where" is not necessary to live joyfully. Concentrating on the things you can be grateful for may be a better solution. Focused on counting your blessings one by one can give you greater hope and resolve.

"Your success and happiness lies in you. Resolve to keep happy, and your joy and you shall form an invincible host against difficulties."
~ Helen Keller

Optimism in your thinking, resolve to overcome life's detours, determination to not let a daunting grief challenges stop you on your journey to find more happiness are all essential elements of personal empowerment. Don't let the tears from your crying about the sun being gone from your life block you from seeing the potential stars of happiness and hope.

"Only when life is difficult, are we challenged to become our greatest selves."
~ Jonathan Lockwood Huie

Let's be honest and frank, grief happenings are difficult and trying. But new possibilities discovered can help you become your greatest self. Follow your heart and don't let anything crush your dreams.

"When It's Darkest, Men See the Stars."
~ Ralph Waldo Emerson

Empowerment to heal from your grief and loss requires you look beyond the darkness you see and feel. Looking for the stars of hope beyond your darkest night may require an attitude shift. Look beyond your shadowy discouragement. You can if you will.

3- Resolve

"Your success and happiness lies in you. Resolve to keep happy, and your joy and you shall form an invincible host against difficulties."
~ Helen Keller

Don't let the tears from your crying about the sun being gone from your life block you from seeing the potential stars of happiness and hope.

"Only when life is difficult, are we challenged to become our greatest selves."
~ Jonathan Lockwood Huie

Let's be honest and frank, grief happenings are difficult and trying. But as you search for solutions the possibilities discovered can help you become your greatest self. Follow your heart and don't let anything crush your dreams.

4- Pray

After you have considered and done all you can never forget the inspiration and strength that can result from communion with God.

"Our prayers should be for blessings in general, for God knows best what is good for us."
~ Socrates

It is good to remember as you pray that God gives you what you need in His good time – but not always when and what you ask for. I have lived with and overcome grief supported each time from inspiration, strength and personal empowerment from communion with my God. You can also.

Be Optimistic. There are answers. Seek them. Have determination and resolve. Pray. Seek the inspiration of communion with God.

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Source by Duane Marchant

Views: 0

October 7, 2019