Tag: production

  • BCG vaccine helps fight infections by boosting immune cell production

    BCG vaccine helps fight infections by boosting immune cell production

    The BCG tuberculosis vaccine boosts the production of immune cells and this may explain how it protects newborns from dying of sepsis
    BCG vaccine helps fight infections by boosting immune cell production
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    https://www.newscientist.com/article/2242866-bcg-vaccine-helps-fight-infections-by-boosting-immune-cell-production/?utm_campaign=RSS%7CNSNS&utm_source=NSNS&utm_medium=RSS&utm_content=home

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  • Global leaders unite to ensure everyone everywhere can access new vaccines, tests and treatments for COVID-19

    Global leaders unite to ensure everyone everywhere can access new vaccines, tests and treatments for COVID-19

    Heads of state and global health leaders today made an unprecedented commitment to work together to accelerate the development and production of new vaccines, tests and treatments for COVID-19 and assure equitable access worldwide.

    The COVID-19 pandemic has already affected more than 2.4 million people, killing over 160,000. It is taking a huge toll on families, societies, health systems and economies around the world, and for as long as this virus threatens any country, the entire world is at risk. 

    There is an urgent need, therefore, while following existing measures to keep people physically distanced and to test and track all contacts of people who test positive, for innovative COVID-19 vaccines, diagnostics and treatments.

    “We will only halt COVID-19 through solidarity,” said Dr Tedros Adhanom Ghebreyesus, WHO Director-General. “Countries, health partners, manufacturers, and the private sector must act together and ensure that the fruits of science and research can benefit everybody.”

    Work has already started. Since January, WHO has been working with researchers from hundreds of institutions to develop and test vaccines, standardize assays and standardize regulatory approaches on innovative trial designs and define criteria to prioritize vaccine candidates.  The Organization has prequalified diagnostics that are being used all over the world, and more are in the pipeline. And it is coordinating a global trial to assess the safety and efficacy of four therapeutics against COVID-19.

    The challenge is to speed up and harmonize processes to ensure that once products are deemed safe and effective, they can be brought to the billions of people in the world who need them. Past experience, in the early days of HIV treatment, for example, and in the deployment of vaccines against the H1N1 outbreak in 2009, shows that even when tools are available, they have not been equally available to all.

    So today leaders came together at a virtual event, co-hosted by the World Health Organization, the President of France, the President of the European Commission, and the Bill & Melinda Gates Foundation. The event was joined by the UN Secretary General, the AU Commission Chairperson, the G20 President, heads of state of France, South Africa, Germany, Vietnam, Costa Rica, Italy, Rwanda, Norway, Spain, Malaysia and the UK (represented by the First Secretary of State).

    Health leaders from the Coalition for Epidemic Preparedness Innovations (CEPI), GAVI-the Vaccine Alliance, the Global Fund, UNITAID, the Wellcome Trust, the International Red Cross and Red Crescent Movement (IFRC), the International Federation of Pharmaceutical Manufacturers (IFPMA), the Developing Countries Vaccine Manufacturers’ Network (DCVMN), and the International Generic and Biosimilar Medicines Association (IGBA) committed to come together, guided by a common vision of a planet protected from human suffering and the devastating social and economic consequences of COVID-19, to launch this groundbreaking collaboration. They are joined by two Special Envoys:  Ngozi Okonjo-Iweala, Gavi Board Chair and Sir Andrew Witty, former CEO of GlaxoSmithKline.

    They pledged to work towards equitable global access based on an unprecedented level of partnership. They agreed to create a strong unified voice, to build on past experience and to be accountable to the world, to communities and to one another.

    “Our shared commitment is to ensure all people have access to all the tools to prevent, detect, treat and defeat COVID-19,” said Dr Tedros. “No country and no organization can do this alone. The Access to COVID-19 Tools Accelerator brings together the combined power of several organizations to work with speed and scale.”

    Health leaders called on the global community and political leaders to support this landmark collaboration and for donors to provide the necessary resources to accelerate achievement of its objectives, capitalizing on the opportunity provided by a forthcoming pledging initiative that starts on 4 May 2020. This initiative, spearheaded by the European Union, aims to mobilize the significant resources needed to accelerate the work towards protecting the world from COVID-19.

     

    Global leaders unite to ensure everyone everywhere can access new vaccines, tests and treatments for COVID-19
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    https://www.who.int/news-room/detail/24-04-2020-global-leaders-unite-to-ensure-everyone-everywhere-can-access-new-vaccines-tests-and-treatments-for-covid-19

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  • Commitment and call to action: Global collaboration to accelerate new COVID-19 health technologies

    Commitment and call to action: Global collaboration to accelerate new COVID-19 health technologies

    Our Vision and Mission

    Grounded in a vision of a planet protected from human suffering
    and the devastating social and economic consequences of
    COVID-19, we, an initial group of global health actors (BMGF,
    CEPI, Gavi, Global Fund, UNITAID, Wellcome Trust, WHO) and
    private sector partners and other stakeholders, are launching
    a landmark, global and time-limited collaboration to accelerate the
    development, production and equitable global access to new COVID-19 essential health technologies.

    We know that as long as anyone is at risk from this virus, the entire
    world is at risk – every single person on the planet needs to be
    protected from this disease.

    We agree that alongside evidence-based public health measures,
    innovative COVID-19 diagnostics, therapeutics and vaccines are
    needed – in record time and at record scale and access – to save
    millions of lives and countless trillions of dollars, and to return
    the world to a sense of ‘normalcy’.

    We recognize the significant amount of critical work, investment
    and initiatives already ongoing around the world to expedite
    the development and deployment of innovative COVID-19 related
    products and interventions.

    We appreciate that while development and deployment of
    innovative products is essential, it will not be enough. We must
    simultaneously and urgently accelerate the strengthening of
    sustainable health systems and capacities to enable delivery of
    the new COVID-19 tools to those who need them and to mitigate
    the knock-on impact on other diseases.

    We remember lessons from the past, which have shown that even
    when effective tools are available to the world, too often some
    are protected, while others are not. This inequity is unacceptable –
    all tools to address COVID-19 must be available to all. In the fight
    against COVID-19, no one should be left behind.

    We understand we cannot do this alone, and that we need to
    work together in unprecedented and inclusive partnership with all
    stakeholders – political leaders, public and private sector partners,
    civil society, academia, and all other stakeholders across society
    – jointly leveraging our comparative strengths and respective
    voices to drive towards collective solutions, an accelerated path,
    and access for all. We are stronger, faster and more effective
    working together.

    Our Mission is not only accelerated development and availability
    of new COVID-19 tools – it is to accelerate equitable global access
    to safe, quality, effective, and affordable COVID-19 diagnostics,
    therapeutics and vaccines, and thus to ensure that in the fight
    against COVID-19, no one is left behind.

    Our Commitment

    1. We commit to the shared aim of equitable global
      access to innovative tools for COVID-19 for all.
    2. We commit to an unprecedented level of partnership
      – proactively engaging stakeholders, aligning and
      coordinating efforts, building on existing collaborations, collectively devising solutions, and grounding
      our partnership in transparency, and science.
    3. We commit to create a strong unified voice to
      maximize impact, recognizing this is not about
      singular decision-making authority, but rather
      collective problem-solving, interconnectedness and
      inclusivity, where all stakeholders can connect and
      benefit from the expertise, knowledge and activities
      of this shared action-oriented platform.
    4. We commit to build on past experiences towards
      achieving this objective, including ensuring that
      every activity we undertake is executed through the
      lens of equitable global access, and that the voices
      of the communities most affected are heard.
    5. We commit to be accountable to the world, to
      communities, and to one another. We are coming
      together in the spirit of solidarity, and in the service
      of humanity, to achieve our mission and vision.

    Our Call

    We ask the global community and political leaders to
    support this landmark collaboration, and for donors to
    provide the necessary resources to accelerate achievement
    of the objectives of this global collaboration, capitalizing
    on the opportunity provided by the rolling pledging
    campaign that will start on 4 May 2020.

    Commitment and call to action: Global collaboration to accelerate new COVID-19 health technologies
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    https://www.who.int/news-room/detail/24-04-2020-commitment-and-call-to-action-global-collaboration-to-accelerate-new-covid-19-health-technologies

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  • EUGENICS AND CHARACTER

    EUGENICS AND CHARACTER

    The rapidly growing interest in Eugenics, and the scientific consideration of the world-wide decline in the birth-rate have drawn attention to the study of the eugenic factors which determine the production of high ability in offspring. Many distinguished investigators have conducted long and exhaustive investigations for the purpose of ascertaining and summarizing all possible biological data concerning the parentage and birth of the most notable persons born in European countries, and to a lesser extent in America.

    The investigations are now acquiring a fresh importance, because, while it is becoming recognized that we are gaining a control over the conditions of birth, the production of children has itself gained an importance. The world is no longer to be bombarded by an exuberant stream of babies, good, bad, and indifferent in quality, with mankind to look on calmly at the struggle for existence among them. Whether we like it or not, the quantity is steadily diminishing, and the question of quality is beginning to assume a supreme significance. The question then is being anxiously asked: “What are the conditions which assure the finest quality in our children?”

    A German scientist, Dr. Vaerting, of Berlin, published just before the War a treatise on the subject of the most favorable age in parents for the production of offspring of ability. He treated the question in an entirely new spirit, not merely as a matter of academic discussion, but rather as a practical matter of vital importance to the welfare of modern society. He starts by asserting that “our century has been called the century of the child,” and that for the child all manner of rights are now being claimed. But, he wisely adds, there is seldom considered the prime right of all the child’s rights, i. e., the right of the child to the best ability and capacity for efficiency that his parents are able to transmit to him. The good doctor adds that this right is the root of all children’s rights; and that when the mysteries of procreation have been so far revealed as to enable this right to be won, we shall, at the same time renew the spiritual aspect of the nations.

    The writer referred to decided that the most easily ascertainable and measurable factor in the production of ability, and efficiency in offspring, and a factor of the greatest significance, is the age of the parents at the child’s birth. He investigated a number of cases of men of ability and efficiency, along these lines, and made a careful summary of his results. Some of his results are somewhat startling, and may possibly require the corroboration of other investigators before they can be accepted as authoritative; but they are worthy of being carefully considered at the present time, pending such further investigation.

    Vaerting found that the fathers who were themselves not notably intellectual have a decidedly more prolonged power of procreating distinguished children than is possessed by distinguished fathers. The former may become the fathers of eminent children from the period of sexual maturity up to the age of forty-three or beyond. When, however, the father is himself of high intellectual distinction, the records show that he was nearly always under thirty, and usually under twenty-five years of age at the time of the birth of his distinguished son, although the proportion of youthful fathers in the general population is relatively small. The eleven youngest fathers on Vaerting’s list, from twenty-one to twenty-five years of age, were with one exception themselves more or less distinguished; while the fifteen oldest, from thirty-nine to sixty years of age, were all without exception undistinguished.

    Among the sons on the latter list are to be found much greater names (such as Goethe, Bach, Kant, Bismarck, Wagner, etc.) than are to be found among the sons of young and more distinguished fathers, for here is only one name (Frederick the Great) of the same caliber. The elderly fathers belonged to the large cities, and were mostly married to wives very much younger than themselves. Vaerting notes that the most eminent men have frequently been the sons of fathers who were not engaged in intellectual avocations at all, but earned their living as humble craftsmen. He draws the conclusion from these data that strenuous intellectual energy is much more unfavorable than hard physical labor to the production of marked ability in the offspring. Intellectual workers, therefore, he argues, must have their children when young, and we must so modify our social ideals and economic conditions as to render this possible.

    Vaerting, however, holds that the mother need not be equally young; he finds some superiority, indeed, provided the father is young, in somewhat elderly mothers, and there were no mothers under twenty-three on the list. The rarity of genius among the offspring of distinguished parents he attributes to the unfortunate tendency to marry too late; and he finds that the distinguished men who marry late rarely have any children at all. Speaking generally, and apart from the production of genius, he holds that women have children too early, before their psychic development is completed, while men have children too late, when they have already “in the years of their highest psychic generative fitness planted their most precious seed in the mud of the street.”

    The eldest child was found to have by far the best chance of turning out distinguished, and in this fact Vaerting finds further proof of his argument. The third son has the next best chance, and then the second, the comparatively bad position of the second being attributed to the too brief interval which often follows the birth of the first child. He also notes that of all the professions the clergy come beyond comparison first as the parents of distinguished sons (who are, however, rarely of the highest degree of eminence), lawyers following, while officers in the army and physicians scarcely figure at all. Vaerting is inclined to see in this order, especially in the predominance of the clergy, the favorable influence of an unexhausted reserve of energy and a habit of chastity on intellectual procreativeness.

    It should be remembered, however, that Vaerting’s cases on his list were all those of Germans, and, therefore, the influence of the characteristic social customs and conditions of the German people must be taken into account in the consideration.

    Havelock Ellis in his well known work “Study of British Genius” dealt on a still larger scale, and with a somewhat more precise method, with many of the same questions as illustrated by British cases. After the publication of Vaerting’s work, Ellis re-examined his cases, and rearranged his data. His results, like those of the German authority, showed a special tendency for genius to appear in the eldest child, though there was no indication of notably early marriage in the parents. He also found a similar predominance of the clergy among the fathers, and a similar deficiency of army officers and physicians.

    Ellis found that the most frequent age of the father was thirty-two years, but that the average age of the father at the distinguished child’s birth was 36.6 years; and that when the fathers were themselves distinguished their age was not, as Vaerting found in Germany, notably low at the birth of their distinguished sons, but higher than the general average, being 37.5 years. He found fifteen distinguished sons of distinguished British fathers, but instead of being nearly always under thirty and usually under twenty-five, as Vaerting found it in Germany, the British distinguished father has only five times been under thirty, and among these only twice under twenty-five. Moreover, precisely the most distinguished of the sons (Francis Bacon and William Pitt) had the oldest fathers, and the least distinguished sons the youngest fathers.

    Ellis says of his general conclusions resulting from this investigation: “I made some attempts to ascertain whether different kinds of genius tend to be produced by fathers who were at different periods of life. I refrained from publishing the results as I doubted whether the numbers dealt with were sufficiently large to carry any weight. It may, however, be worth while to record them, as possibly they are significant. I made four classes of men of genius: (1) Men of Religion, (2) Poets, (3) Practical Men, (4) Scientific Men and Sceptics. (It must not, of course, be supposed that in this last group all the scientific men were sceptics, or all the sceptics scientific.) The average age of the fathers at the distinguished son’s birth was, in the first group, 35 years; in the second and third group, 37 years; and in the last group, 40 years. (It may be noted, however, that the youngest father of all the history of British genius, aged sixteen, produced Napier, who introduced logarithms.)

    “It is difficult not to believe that as regards, at all events, the two most discrepant groups, the first and last, we come upon a significant indication. It is not unreasonable to suppose that in the production of men of religion in whose activity emotion is so potent a factor, the youthful age of the father should prove favorable; while for the production of genius of a more coldly intellectual and analytic type more elderly fathers are demanded. If that should prove to be so, it would become a source of happiness to religious parents to have their children early, while irreligious parents should be advised to delay parentage.

    “It is scarcely necessary to remark that the age of the mothers is probably quite as influential as that of the fathers. Concerning the mothers, however, we always have less precise information. My records, so far as they go, agree with Vaerting’s for German genius, in indicating that an elderly mother is more likely to produce a child of genius than a very youthful mother. There were only fifteen mothers recorded under twenty-five years of age, while thirteen were over thirty-nine years; the most important age for mothers was twenty-seven.

    “On all these points we certainly need controlling evidence from other countries. Thus, before we insist with Vaerting that an elderly mother is a factor in the production of genius, we may recall that even in Germany the mothers of Goethe and Nietzsche were both eighteen at their distinguished son’s birth. A rule which permits of such tremendous exceptions scarcely seems to bear the strain of emphasis.”

    The student, however, must always remember that while the study of genius and exceptionable talent is highly interesting, and even, as is quite probable, not without significance for the general laws of heredity, still we must beware of too hastily drawing conclusions from it to bear on the practical questions of eugenics. Genius is rare—and, in a certain sense, abnormal. Laws meant for application to the general population must be based on a study of the general population. Vaerting, himself, realized how inadequate it was to confine our study to cases of genius.

    Another investigator, Marro, an Italian scientist, in his well-known book on puberty which was published several years ago, brought forth some interesting data showing the result of the age of the parents on the moral and intellectual characters of school-children in Northern Italy. He found that children with fathers below twenty-six at their birth showed the maximum of bad conduct and the minimum of good; they also yielded the greatest proportion of children of irregular, troublesome, or lazy character, but not of really perverse children—the latter being equally distributed among fathers of all ages. The largest number of cheerful children belonged to the young fathers, while the children tended to become more melancholy with ascending age of the fathers. Young fathers produced the largest number of intelligent, as well as of troublesome children; but when the very exceptional intelligent children were considered separately, they were found to be more usually the offspring of elderly fathers.

    As regarded the mothers, Marro found that the children of young mothers (under twenty-one) are superior, both as regards conduct and intelligence, though the more exceptionally intelligent children tended to belong to more mature mothers. When the parents were both in the same age-groups, the immature and the elderly groups tended to produce more children who were unsatisfactory, both as regards conduct and intelligence—the intermediate group yielding the most satisfactory results of this kind.

    Havelock Ellis makes the following plea for further investigations along these lines, in the interest of the well-being of the race: “But we have need of inquiries made on a more wholesale and systematic scale. They are no longer of a merely speculative character. We no longer regard children as the ‘gifts of God’ flung into our helpless hands; we are beginning to realize that the responsibility is ours to see that they come into the world under the best conditions, and at the moments when their parents are best fitted to produce them. Vaerting proposes that it should be the business of all school authorities to register the ages of the pupils’ parents. This is scarcely a provision to which even the most susceptible parent could reasonably object, though there is no cause to make the declaration compulsory where a ‘conscientious’ objection existed, and in any case the declaration would not be public.

    “It would be an advantage—although this might be more difficult to obtain—to have the date of the children’s marriage, and of the birth of previous children, as well as some record of the father’s standing in his occupation. But even the ages of the parents alone would teach us much when correlated with the school position of the pupil in intelligence and conduct. It is quite true that there are unavoidable fallacies. We are not, as in the case of genius, dealing with people whose life-work is complete and open to the whole world’s examination.

    “The good and clever child is not necessarily the forerunner of the first-class man or woman; and many capable and successful men have been careless in attendance at lectures, and rebellious to discipline. Moreover, the prejudice and limitations of the teachers have to be recognized. Yet when we are dealing with millions most of these fallacies would be smoothed out. We should be, once for all, in a position to determine authoritatively the exact bearing of one of the simplest and most vital factors of the betterment of the race. We should be in possession of a new clue to guide us in the creation of the man in the coming world. Why not begin today?”

    Considerable attention on the part of the American thinking public has been directed toward the investigations and researches of Casper L. Redfield. Mr. Redfield combats the orthodox scientific position that the acquired qualities are not transmitted to offspring; and he most positively states that such characteristics are transmitted to offspring, and are really the causes which have tended toward the evolution and progress of the race. But he insists upon this vital point, namely, that the parent must already have acquired improved quality before he can transmit improvement to the offspring—and that before he can have acquired this improved quality, he must have lived sufficiently long to have experienced the causes which have developed improvement in himself. Consequently, he holds that delayed parentage produces great men.

    Mr. Redfield several years ago offered a prize of two hundred dollars to anyone who could show that a single one of the great men of history was the product of a succession of young parents, or was produced by a line of ancestry represented by more than three generations to a century. But no one ever claimed the prize money. According to Mr. Redfield’s doctrine, race improvement is and will be accomplished as the result of effort, physical and mental, upon the part of prospective parents, particularly if the period of effort is sustained over a considerable number of years previous to reproduction.

    The following quotations from Mr. Redfield’s writing will give a general idea of his lines of thought and his theories. He says:

    “At some time in the past there was a common ancestor for man and the ape. At that time the mental ability of the man was the same as that of the ape, because at that time man and the ape were the same person. From that common ancestor there have been derived two main lines of descent, one leading to man and the other to the ape of today. In the line leading to man, mental ability has increased little by little so that today the mental ability of the man is far above that of the ape. While it may not be literally true for each and every generation between that common ancestor and man of the present time, still we will commit no error if we divide the total increase in mental ability by the number of intervening generations and say that each generation in turn was a little superior to that which produced it. Now it happens that mental ability is something which is inherited—is transmitted from parent to offspring. Take that fact with the fact that there has been a regular (or irregular) increase in mental ability in the generations leading to man, and it will be seen that each generation in succession transmitted to its offspring more than it inherited from its parents. But a parent cannot transmit something which he did not have. Where and how did those generations get that ability which they transmitted but did not inherit?”

    Mr. Redfield in his writings shows that what is true of the human race is true of high-bred domesticated animals, namely, the cow of high milk producing breeds; the fast running and trotting horses; and the highly developed hunting dogs. To each case he applies his question: “Where and how did those generations of animals get that power which they transmitted but did not inherit?” In his investigations he claims to have discovered the secret, namely, that the ancestors, throughout several generations, had each acquired the power which it transmitted, which added to the inherited power raised the general power of the stock. This arose from careful breeding, and directly from the fact that the average age of the parent was much higher in the highly-bred stock than in the “scrub” or ordinary run of stock. In other words, delayed parentage produced better offspring.

    Mr. Redfield proceeds to argue from these facts as follows: “At one time man and ape reproduced at the same average age, whereas now they reproduce at widely different ages. Going back to the time when man and ape separated, our ancestors survived by physical and mental activity in securing food and escaping from enemies. As time went on man reproduced at later and later average age until now he reproduces at about thirty years from birth of parent to birth of offspring. When time between generations stretched out in the man line more than it did in the ape line, the man acquired more mental development before he reproduced than did the ape, and he did this because he was mentally active more years before reproducing. The successive generations leading to modern man transmitted to offspring more than they inherited from their parents, and the generations which did this are the same generations which acquired, before reproducing, the identical thing which they transmitted in excess of inheriting.

    “Coming now to those rare men of whom we have only a few in a century, how were they produced? It should be noted that each one had two parents, four grandparents, and eight great-grandparents. Also that they are certainly improvements over their great-grandparents. If they were not such improvements, then there would be many ‘rare’ cases in a century. In looking into the pedigrees of these great men it is found that they were sons of parents of nearly all ages, but were predominantly sons of elderly parents. While we sometimes find comparatively young parents in the pedigree of a great man, we never find a succession of young parents. Neither do we find an intellectually great man produced by a pedigree extending over three generations. The great man is produced only when the average for three generations is on the elderly side of what is normal. The average age of one thousand fathers, grandfathers, and great-grandfathers in the pedigrees of eminent men was found to be over forty years. Great men rise from ordinary stock only when several generations in succession acquire mental efforts in excess amounts before reproducing.”

    It is the opinion of the present writer that the theories of Mr. Redfield are in the main true, and that in the future much valuable information will be obtained along the same lines, which will tend to corroborate his general conclusions. One’s attention needs but to be plainly directed to the matter, and then he will see that it is absurd to think of a creature transmitting to his offspring qualities which neither he or his mate had inherited or acquired. If there were no transmission of acquired qualities there would be no improvement—and in fact, we know that the bulk of inherited qualities were at some time in the history of the race “acquired.” And, reasoning along the same line, we may see that the young parents who have not had as yet an opportunity to acquire mental power cannot expect to transmit it to their offspring—all that they can do is to transmit the inherited stock qualities plus the small acquired power which they have gained in their limited experience. And, finally, it is seen that offspring produced at a riper age of parenthood, continued over several generations, tend toward unusual ability and powers. Consequently, the people or nation with a higher average age of parenthood may logically expect to attain greater mental powers than the peoples lacking that quality. And what is true of a people or nation is of course true of a particular family.

    The subject touched upon in this part of our book is one of the greatest interest to careful students of Eugenics; and is one which calls for careful and unprejudiced consideration from all persons having the interest of the race at heart.

    PRIVATE Sex Advice to Women By R. B. Armitage, M. D.

    For Young Wives and those who Expect to be Married.

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