Tag: Modeling

  • Massive proportion of world’s population are living with herpes infection

    Massive proportion of world’s population are living with herpes infection

    Virus causing genital herpes may put millions of people at greater risk of infection with HIV

    About half a billion people worldwide are living with genital herpes, and several billion have an oral herpes infection, new estimates show.

    Authored by staff at the University of Bristol, World Health Organization (WHO), and Weill Cornell Medical College-Qatar, and published in the Bulletin of the World Health Organization,
    the new study estimates the global infection prevalence and incidence of herpes simplex virus types 1 and 2 (HSV-1 and HSV-2) in 2016. 

    “Herpes infection affects millions of people across the globe and can have far-reaching health effects. We need more investment and commitment to develop better treatment and prevention tools for this infection.” says Dr Sami Gottlieb, Medical
    Officer at WHO and an author of the study.

    Prevalence and incidence

    An estimated 491.5 million people were living with HSV-2 infection in 2016, equivalent to 13.2% of the world’s population aged 15 to 49 years. HSV-2 is almost exclusively sexually transmitted, causing infection in the genital or anal area (genital
    herpes).

    An estimated 3.7 billion people had HSV-1 infection during the same year – around 66.6% of the world’s population aged 0 to 49. HSV-1 is mainly transmitted by oral to oral contact to cause infection in or around the mouth (oral herpes). However,
    HSV-1 can also be transmitted to the genital area through oral-genital contact – during oral sex – to cause genital herpes. Most HSV-1 infections were oral; however, between 122 million to 192 million people were estimated to have genital
    HSV-1 infection, depending on the assumptions used in the estimation model.

    Because herpes is a lifelong infection, estimated prevalence increased with age; HSV-2 prevalence was also higher among women and in the WHO African Region.

    Health and social impacts

    Most people living with herpes, caused by either HSV-1 or 2, are unaware they have the infection.

    When symptoms do occur however, oral herpes infection can lead to painful sores around the mouth (“cold sores”). Genital herpes infection can cause recurring, often painful, genital sores, often referred to as genital ulcer disease. 

    WHO and partners published a study in March 2020 estimating that around 5% of the world’s population (187 million people) suffered from at least one episode of herpes-related genital ulcer disease in 2016 (1). Most of these episodes were due to
    HSV-2, which can recur frequently over many years.

    Recurrent symptoms of genital herpes can lead to stigma and psychological distress, and can have an important impact on quality of life and sexual relationships. However, in time, most people with herpes adjust to living with the infection.

    “Genital herpes is a substantial health concern worldwide – beyond the potential pain and discomfort suffered by people living with the infection, the associated social consequences can have a profound effect on sexual and reproductive health”
    says Dr Ian Askew, Director of the Department of Sexual and Reproductive Health and Research at WHO. 

    Herpes and HIV

    A strong association exists between HSV-2 infection and HIV infection. In 2019, WHO commissioned a modeling study to estimate how much HSV-2 infection might contribute to HIV incidence. The study estimated that almost 30% of new sexually acquired HIV
    infections in 2016 worldwide were likely attributable to HSV-2 infection (2). 

    Evidence shows that people with HSV-2 infection are at least three times more likely to become infected with HIV, if exposed. HSV-2 leads to inflammation and small breaks in the genital and anal skin that can make it easier for HIV to cause infection.
    In addition, people with both HIV and HSV-2 infection are more likely to spread HIV to others.

    Women have higher biologic susceptibility to both HSV-2 and HIV. Women living in the WHO Africa Region have the highest HSV-2 prevalence and exposure to HIV – putting them at greatest risk of HIV infection, with negative implications for their health
    and well-being. 

    For people living with HIV (or who are living with other conditions that compromise their immune systems) as well as HSV-2, the symptoms of herpes can be more severe and more frequent. 

    Neonatal herpes

    Neonatal herpes can occur when an infant is exposed to HSV in the genital tract during delivery. This is a rare condition, occurring in an estimated 10 out of every 100,000 births globally, but can lead to lasting neurologic disability or death. The risk
    for neonatal herpes is greatest when a mother acquires HSV infection for the first time in late pregnancy. Women who have genital herpes before they become pregnant are at very low risk of transmitting HSV to their infants.

    No cure – better treatment and prevention needed

    There is no cure for herpes. At present, antiviral medications, such as acyclovir, famciclovir, and valacyclovir, can help to reduce the severity and frequency of symptoms but cannot cure the infection.

    As well as increasing awareness about HSV infection and its symptoms, improved access to antiviral medications and heightened HIV prevention efforts for those with genital HSV symptoms are needed globally. 

    In addition, development of better treatment and prevention interventions is needed, particularly HSV vaccines. WHO and partners are working to accelerate research to develop new strategies for prevention and control of HSV infections. Such research includes
    the development of HSV vaccines and topical microbicides. Several candidate vaccines and microbicides are currently being studied.

    “A vaccine against HSV infection would not only help to promote and protect the health and well-being of millions of people, particularly women, worldwide – it could also potentially have an impact on slowing the spread of HIV, if developed
    and provided alongside other HIV prevention strategies” says Dr Meg Doherty, Director of the WHO Department of Global HIV, Hepatitis, and STI Programmes.

    Related publications

    WHO guidelines for the treatment of Genital Herpes Simplex Virus

    WHO preferred product characteristics for herpes simplex virus vaccines

     

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    (1) Looker KJ, Johnston C, Welton NJ, et al. The global and regional burden of genital ulcer disease due to herpes simplex virus: a natural history modelling study. BMJ Glob Health. 2020;5(3):e001875. doi: 10.1136/bmjgh-2019- 001875.

    (2) Looker KJ, Welton NJ, Sabin KM, et al.Global and regional estimates of the contribution of herpes simplex virus type 2 infection to HIV incidence: a population attributable fraction analysis using published epidemiological data. Lancet Infect Dis.2020;20(2):240-249. doi: 10.1016/S1473-3099(19)30470-0.

    Massive proportion of world’s population are living with herpes infection
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    https://www.who.int/news-room/detail/01-05-2020-massive-proportion-world-population-living-with-herpes-infection

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  • Study shows widely used machine learning methods don’t work as claimed

    Study shows widely used machine learning methods don’t work as claimed

    Models and algorithms for analyzing complex networks are widely used in research and affect society at large through their applications in online social networks, search engines, and recommender systems. According to a new study, however, one widely used algorithmic approach for modeling these networks is fundamentally flawed, failing to capture important properties of real-world complex networks.

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    https://techxplore.com/news/2020-03-widely-machine-methods-dont.html

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  • Fueling a cleaner future for transport

    Fueling a cleaner future for transport

    A simple, fast and inexpensive method for modeling the combustion characteristics of gasoline has been developed by KAUST researchers, paving the way for cleaner and more efficient transport fuels.

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  • Study: Modern electric grid needs smarter modeling for improved resilience

    Study: Modern electric grid needs smarter modeling for improved resilience

    Power systems and communication networks are increasingly interdependent, which can affect the response and recovery times when problems occur.

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  • Helping non-experts create mathematical models through natural selection

    Helping non-experts create mathematical models through natural selection

    Science and engineering applications such as control of high-precision motion systems or electrochemical processes are often built on mathematical models of dynamic systems. Ph.D. candidate Dhruv Khandelwal developed a framework that allows people without experience in data-driven modeling to fairly easily develop high-quality, optimized mathematical models of these dynamic systems. This is a vital tool that can help researchers of any stripe navigate the complex maze of modeling technologies and systems dynamics, and support data-driven research output and valorization. For instance, electrical engineers managing the health of the electricity grid or researchers studying the growth of cancer cells. Khandelwal defends his Ph.D. thesis on March 4.

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  • Discover How to Become Rich, Famous & Successful With a Modeling Career

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    The road to becoming rich, famous and successful in modeling is not for everyone though. In the old days you had to be extra extra skinny in order to become a rich and famous model. Today however there are far more modeling avenues that entice many looks and body types.

    You may have looked at a fashion magazine and have a pretty good idea of what modeling is. To get a good look into the requirements of modeling you may want to catch an episode of Americas Next Top Model. Most of the models on the tv show are high fashion models, but you may be wanting to get into another type of modeling like plus size industry. Modeling is everywhere we go and look. Only you know what kind of model you could be but be truthful with you self.

    Before you jump into pursuing a modeling career you need to make sure your are doing it for the right reasons. If not you will misguide yourself and will not make it to where you want. If you think modeling is a good way to jump start your singing or acting career you best think about it again. People with this attitude rarely make it very far in modeling. All the top modeling professionals frown upon people like this everyday. To become rich, famous and successful in a modeling career you will need to have dedication and passion.

    If you are male you will need to step outside of your shell to succeed. You see more female models than you do male models. Do not let this get you down by thinking you have to display big muscles. Modeling has went through many changes since the early days. Over time new genres, styles and looks have been added with even more on the way. You just might have that new style consumers are trying to find. You just never know in our ever changing world.

    To be successful in a career of modeling you will need a high level of self confidence and ambition. No matter if you are female, male or what your body type is. When you enter into modeling you will have to work extra hard to be be transformed into a popular well known face. Be careful not to get ties up with an agency that does not treat or handle their clients honestly and respectfully. Every good agency will not need you to give them money. They will earn money once you land your first modeling gig.

    When you find open calls make sure you go and do not talk yourself into not going no matter what you are thinking. Just do it. You see an open call is just as good as open houses where interested models are invited to be interviewed. You need to dress in clothing that will exhibit your body type and features. You will also want to pick an outfit out that is fashionable. This is your chance to prove yourself to the representatives of the agency. You will not stand out to them if you just wear your normal everyday clothes. To become famous you have to act like your famous in order to become rich, famous and successful in modeling.

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    Source by Dennis J. Cole

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