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  • Making available free paediatric medicine can accelerate elimination of congenital Chagas disease

    Making available free paediatric medicine can accelerate elimination of congenital Chagas disease

    The donation of an essential antiparasitic medicine can potentially accelerate the elimination of Chagas disease infection in children. A pediatric presentation of benznidazole with accurate dosage and will soon be made available freely to address
    a long-standing gap in the treatment of congenital infections of Chagas disease.  

    The donation, by the Mundo Sano Foundation1 and INSud Pharma2 group to the World Health Organization (WHO), is expected to become effective soon.

    “Making benznidazole freely available for the treatment of newborns and children until the age of 19 will be a game-changer in the fight against Chagas disease” said Dr Mwelecele Ntuli Malecela, Director, WHO Department of Control
    of Neglected Tropical Diseases. “This can save future generations from developing life-threatening and fatal complications and also boost up diagnosis and treatment contributing to congenital Chagas disease elimination.”

    The three-year agreement will make available 108 000 tablets of benznidazole3 – one of the two antiparasitic medicines against Chagas disease. Treatment4 with benznidazole in the early stages of infection can cure Chagas
    disease, prevent or curb disease progression and prevent congenital transmission in pregnant women.

     “We have now added the systematic detection and treatment of all newborns and children under 19 which was not part of  our recent switch from control to elimination of congenital Chagas disease” said Dr Pedro Albajar
    Vinas, Medical Officer, WHO Department of Control of Neglected Tropical Diseases. “In addition, screening of pregnant women at risk of infection who have not had past antiparasitic treatment provides an excellent opportunity for prevention of posterior transmission throughout pregnancy and birth.”

    Each year, an estimated 15 000 children are born from infected mothers. 

    The agreement

    The donation by Mundo Sano Foundation for the duration of the agreement comprises benznidazole:

    • 105,000 tablets of 100mg
    • 3,000 tablets of 12.5mg

    Furthermore, the Foundation may donate funds to support activities associated with distribution of medicines and is ready to consider extending this agreement beyond the specified duration of three years.

    The disease

    Chagas disease, also known as American trypanosomiasis, is a potentially life-threatening illness caused by the protozoan parasite Trypanosoma cruzi (T. cruzi).

    Although considerable progress has been achieved, particularly in reducing vector transmission and screening of blood and organ supply, reaching, diagnosing and providing healthcare for people most affected has been a challenge.

    Currently, under-diagnosis of Chagas disease cases is as high as 90% and under-diagnosis of congenital and paediatric cases is believed not to be lower.

    Globally, an estimated 6-7 million people are infected with T. cruzi.

    The disease is found mainly in endemic areas of 21 continental Latin American countries5. But movement of people to urban areas and to other continents has expanded its transmission through non vectorial routes, such as blood transfusion,
    congenital transmission, organ transplants and oral transmission through food contamination.

    Considering that neglected tropical disease as a growing public health problem in many countries, the World Health Assembly – WHO’s decision-making body – decided in May 2019 to commemorate World Chagas Disease Day on 14 April.

    The inaugural celebration happens this year.

    1Mundo Sano is a nonprofit international foundation working with the public and private sectors, academia, and other international organizations to provide solutions to the affected communities and generate scientific knowledge.
    In 2012, it led a public-private consortium in 2012 to produce benznidazole in Argentina.

    2Insud Pharma (formerly known as Chemo Group) specializes in research, development, manufacture, sale and marketing of active pharmaceutical ingredients and medicinal products for human and veterinary use.

    3In 2017, the United States Food and Drug Administration (FDA) approved benznidazole for the treatment of children aged 2–12, making it the first treatment approved in the United States for Chagas disease.

    4Nifurtimox is also 100% effective in curing Chagas disease if given soon after onset of infection, including cases of congenital infection. It is donated by Bayer who pledged more than 7.5 million tablets for the period 2012-2021.

    5Argentina, Belize, Bolivia (Plurinational State of), Brazil, Chile, Colombia, Costa Rica, Ecuador, El Salvador, French Guiana, Guatemala, Guyana, Honduras, Mexico, Nicaragua, Panama, Paraguay, Peru, Suriname, Uruguay, and Venezuela
    (Bolivarian Republic of).

     

     

     

     

    Making available free paediatric medicine can accelerate elimination of congenital Chagas disease
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    https://www.who.int/news-room/detail/02-04-2020-making-available-free-paediatric-medicine-can-accelerate-elimination-of-congenital-chagas-disease

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  • WHO Action framework to advance universal access to safe, effective and quality assured blood products 2020 -2023

    WHO Action framework to advance universal access to safe, effective and quality assured blood products 2020 -2023

    In response to calls for action, WHO has provided guidelines, physical standards, training and technical support to improve blood product quality, safety and availability in WHO regions and in countries. Despite these actions, progress in blood availability and safety under effective regulation has been slow in many parts of the world.

    For that reason, the WHO Action framework for blood products 2020-2023, proposes a renewed effort to scale up programme implementation to improve global adequacy of blood donation, and universal access to quality and safe blood and blood components for transfusion, and plasma derived medicinal products.

    The Action Framework provides strategic direction to WHO’s work for the years 2020-2023. It identifies six strategic objectives: appropriately structured, well-coordinated and sustainably resourced national blood systems; regulatory capacity to ensure the quality and safety of blood; functioning and efficiently managed blood services; effective implementation of patient blood management to optimize transfusion practices, effective surveillance, haemovigilance and pharmacovigilance, supported by comprehensive and accurate data collection systems; and partnerships, collaboration and information exchange to achieve key priorities and jointly address challenges and emerging threats at global, regional and national levels.

    The Action Framework will improve coordination and collaboration at all levels of WHO. The document will promote and strengthen new and existing partnerships, as areas for collaborative action are clearly identified. Moreover, it demonstrates the need for support to WHO (including sustainable funding) to coordinate the implementation of this ambitious plan. As a result, the Action Framework for blood products will allow WHO to more effectively carry out its mandate on blood, and to increase the impact of WHO activities to strengthen blood systems and blood regulation in countries and regions and eventually to ensure universal access to blood products worldwide.

     

    WHO Action framework to advance universal access to safe, effective and quality assured blood products 2020 -2023
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    https://www.who.int/news-room/detail/19-02-2020-who-action-framework-to-advance-universal-access-to-safe-effective-and-quality-assured-blood-products-2020–2023

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  • Ancient Medicinal Wisdom: Vedic Healing With Coriander

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    In Ayurveda, the rasa or taste of coriander is initially sharp or astringent. Digestion mellows this to sweetness.

    What is Ayurveda?

    This is the ancient medical system of India. Ayurveda postulates that there are three basic types of energy or doshas: Vata dosha or wind energy, Pitta dosha or fire energy, and Kapha dosha or water energy. Every individual, (indeed, all matter), is made up of different degrees and combinations of these doshas. This is called the prakriti or constitution of the individual.

    Ayurvedic belief is that coriander, seeds as well as the plant, is beneficial to all body types or doshas as it does not arouse pitta like most other spices.

    Coriander leaves, seeds and powder are used extensively in Indian kitchens because of their appetising aroma. Ancient Ayurvedic practice had recognized the benefits of coriander: the use of these seeds and powder is rooted in this.

    Multiple benefits of Coriander:

    • These seeds contain dietary fibre and this aids in good bowel movements. It also helps in removing intestinal gas and prevents nausea. Coriander seeds can be dry roasted, powdered and added to most dishes; it’s not all about flavor, they are a good digestive aid. Ayurveda tells us so!
    • It will stimulate appetite by helping to produce digestive enzymes and aid in the breakdown of food.
    • It is also good for liver function. This is probably why it is a good appetite stimulant.
    • Coriander powder and seeds do not arouse pitta. In modern scientific terms, coriander is alkaline. Thus, it is good for urinary tract infections. It is also a mild diuretic.
    • These are an age-old cure for menstrual cramps: just boil 1-2 teaspoons of coriander seeds in half a litre of water, add a teaspoon of organic sugar and drink warm. The relief is palpable.
    • Ayurveda has always known it; now modern research shows coriander seeds to inhibit bacterial growth thus making them a good anti-bacterial agent. This inhibitive property makes coriander a good fighter of stomach infections.
    • Anti-bacterial coriander is also a good anti-fungal. Coriander seeds are quite useful in fighting skin problems like eczema, itchy skin, and rashes.
    • It contain linoleic acid which is why they provide pain relief as well as act as an anti-inflammatory. This property also makes them useful in curing mouth ulcers and sores.
    • Ayurvedic cures for chronic conditions like arthritis make liberal use of coriander seeds/powder. A ‘tea’ is made by boiling ground coriander seeds in water and drinking the warm decoction.

    Here are some Ayurvedic recipes for different ailments which make generous use of coriander seeds:

    • That parched feeling that a fever causes can be relieved by boiling 1 teaspoon of coriander powder in 1 cup of water. Drink after cooling, and your thirst will vanish.
    • For fatigue or a burning sensation in the body, soak a teaspoon of coriander seeds in a glass of water. Let it stand overnight. Strain and drink first thing in the morning.
    • Boil 1 tsp of coriander seeds in half a litre of water. Let it stand for 10 minutes. Strain and drink. This relieves any burning sensation while urinating.
    • Do not pop a pill at the first signs of malaise.The harmful effects of unnecessarily medicating yourself can be controlled by these simple home remedies which carry the goodness of Mother Nature. Ayurveda views human beings as an integral part of larger creation and treats human ailments non-aggressively.
    • When medicines should be used with circumspection, what can one say about the harmful chemicals that we ingest every day unknowingly? Food production in the modern day is fraught with dangerous practices. The indiscriminate use of chemical methods of farming is poisoning almost everything we eat. The organic movement aims to reverse this. If you want to enjoy the maximum benefit of any food product, GO ORGANIC. Coriander is no different.
    • Terragreens Organic is a store of the freshest and most natural ingredients, untouched by chemicals. Enjoy the full benefit of this miracle of Mother Nature. Buy your coriander seeds or powder from the best!

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    Source by Karthik Guduru

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