Tag: Functions

  • Rap1, a potential new target to treat obesity

    Rap1, a potential new target to treat obesity

    cientists at Baylor College of Medicine, the National Institutes of Health and Virginia Tech Carilion Research Institute have discovered a new mechanism in the mouse brain that regulates obesity. The study, which appears in Cell Reports today, shows that this new mechanism can potentially be targeted to treat obesity.

    “It’s well known that the brain is involved in the development of obesity, but how a high-fat diet changes the brain so it triggers the accumulation of body fat is still unclear,” said senior author Dr. Makoto Fukuda, assistant professor of pediatrics at Baylor and the USDA/ARS Children’s Nutrition Research Center at Baylor and Texas Children’s Hospital.

    Fukuda and colleagues studied the mouse Rap1 gene, which is expressed in a variety of tissues, including the brain where it is involved in functions such as memory and learning. Little was known, however, of the role brain Rap1 plays in energy balance.

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  • Distinguishing Drug Abuse From Drug Addiction

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    Though “drug abuse” and “drug addiction” are often used interchangeably, in reality the terms refer to two distinct behavior patterns. An individual can abuse or misuse drugs without being inevitably addicted to them. Abuse or misuse involves the use of drugs defying the culturally acceptable standards or medically prescribed doses to attain a certain effect. The substances abused may be legal, such as alcohol or prescription drugs, or illegal, like heroin and other street drugs which have no medicinal value.

    On the other hand, drug addiction, or compulsive drug use, refers to an uncontrollable desire to use a drug in spite of being aware of harmful psychological and physiological effects that they can have on the body. Addiction is often characterized by an insatiable appetite for substances by increasing the dosage, leading to a complete dependence on them.

    Since abuse and addiction are two distinct concepts, their causes are unique as well. Abuse is generally considered to be more complicated but it is not necessarily triggered by any motivational factor, unlike addiction which is caused by a powerful motivational force. Therefore, in most of the cases, abuse may not always result in addiction, but addiction can certainly lead to abuse.

    Impact of drug abuse and addiction on the brain

    It has been observed that both drug abuse and drug addiction have similar effects on mind and body. People often view abuse and addiction as a moral weakness or character flaw. One of the common myths surrounding drug use is that quitting it is directly linked to behavioral changes. In reality, addiction is a disease which alters the brain functions, hijacking the natural motivational control circuits. Thus, quitting is simply not a matter of choice or willpower. Though, the decision to use the drug initially might be voluntary, changes in the brain structure due to repeated drug use can inhibit someone’s self-control and decision-making ability, causing intense cravings.

    Experts attribute the inability to refrain from drug use to these changes in the brain. However, modern medical advancements have led to the development of an array of treatment and rehabilitation options to combat the disastrous effects of addiction and help abusers take control of their lives. Studies have shown that a combination of medications and behavioral therapy can boost the recovery process with minimal withdrawal effects.

    Possible reasons leading to drug abuse and addiction

    For those who are dependent on illegal substances, it can be difficult to know whether they have crossed the limit. Here are some possible reasons that can trigger drug abuse or addiction:

    • Connecting socially: A strong desire driven by an urge to fit into a certain group could lead people toward drugs.
    • Dealing with problems in life: Continuous drug use can get individuals accustomed to it, and soon it might become the only way to escape from problems and challenges.
    • Using drugs to combat other issues: Serious concerns, such as panic attacks or chronic pain, can cause dependence on drugs, until people discover healthier alternative methods to counter such problems.
    • Strong influence of any drug: Frequent use of drugs triggers dependence on them. Thus, what started as a voluntary choice may slowly transform into a physical and psychological need.

    Leading a drug-free life

    Many families and individuals have suffered great losses due to addiction to drugs. Fortunately, there is hope, though the battle to eliminate addiction and regain sobriety is challenging. There are numerous treatment strategies that can go a long way in helping people come out of their addiction-related problems.

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    Source by Barbara Odozi

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  • Enterpriship – The Art and Science of Entrepreneurship, Leadership, and Management

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    Every individual who starts, owns, or is a member of the management team of an enterprise, should strive to build sustainable advantage. Sustainable advantage is essential to value creation because cash flows become predictable and reliable over long periods of time. As a consequence, it is easier to plan for investments in new endeavors and to maintain contingency reserves for downturns.

    Building sustainable advantage requires proficiency in the disciplines of entrepreneurship, leadership, and management. Collectively, these three disciplines embrace “enterpriship.”

    Enterpriship is both an art and a science. Art is an occupation that requires both knowledge and skills; science is method for systematizing knowledge. Through both knowledge and skills, enterpriship provides a systematized approach to building sustainable enterprises by employing the techniques of entrepreneurship, leadership, and management.

    Entrepreneurship is a competency for starting, developing, and assuming risk for an enterprise. Leadership is a competency for aspiring, inspiring, and motivating others. Management is a competency for directing and controlling events and activities – management as a “team” has the authority and responsibility for the enterprise.

    Being proficient in all three competencies requires experience. Entrepreneurs may lack the leadership and management competencies, leaders may lack entrepreneurial and management competencies, and managers may lack the entrepreneurial and leadership competencies to build a sustainable enterprise.

    Upwardly mobile entrepreneurs have to demonstrate to investors that they can build large markets. Lifestyle business enterprise owners, such as dry cleaners, hairdressers, professional service providers, restaurateurs, and retailers, are responsible for everything in their businesses. Executives and managers in larger enterprises are under constant pressure from investors to generate quality earnings on an ongoing basis.

    The enterprise depends upon the use of all three enterpriship competencies as do the employees, customers, suppliers and investors.

    When entrepreneurs start enterprises, they tend to focus on the benefits and features of their products and/or services. Intrapreneurs, who are agents of change in established enterprises, tend to do the same thing. However, focusing on products and/or services alone is insufficient for building sustainable advantage over time.

    Without people there is nothing in business. Processes must be effective and efficient at delivering quality products and/or services conveniently. If an enterprise can’t deliver, a competitor will.

    Hence, the management team collectively must be proficient in entrepreneurial, leadership, and managerial roles that dictate successful people-oriented, process-oriented, and product and/or service capabilities.

    The entrepreneurial role is both process-oriented and product-oriented, through which innovative ideas are transformed into value at every stage of an enterprise’s development.

    The leadership role is people-oriented, through which direction is set that others will follow to achieve results – equally applicable to top-level executives, team leaders within functions, or anywhere in between.

    The managerial role is process-oriented, through which resources (time, materials, and supplies) are applied to activities to achieve results.

    These three roles embrace the planning and policy development, deployment and execution, and performance measurement activities of the enterprise. Deployment means positioning the resources of the enterprise in the best markets for its products and/or services. Execution means getting things done through people and processes effectively and efficiently.

    Unless the management team employs these three enterpriship competencies collectively to address people, process, and product and/or service capabilities, the enterprise will be unable to build sustainable advantage over time, and will ultimately decline, and maybe fail.

    If the management team can systematize building sustainable advantage through the effective and efficient use of people and processes, then there more time to spend on developing the benefits and features of products and/or services. Enterpriship provides the approach…

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    Source by Nigel Brooks

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  • Can Rabbits Change Gender / Sex?

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    I have seen this question on many forums and over heard breeders discussing the fact that their rabbit changed gender. In fact rabbits that have won awards at ARBA conventions as a doe, have been shown later only to find out it was actually a buck. Does this mean that a rabbit has changed sex?

    Amazingly in nature there are some instances where an animal can change its gender. Take for example a clown fish. Clown fish live in schools. Within that school is a leadership structure led be a female clown fish. When that clown fish dies, the highest male in leadership takes over for the female and changes gender including reproductive functions. This is however a rarity for this type of biological change to take place. In fact there are even more rare cases of humans that have changed gender as a result of either 5-alpha-reductase deficiency (5alpha-RD-2) or 17-beta-hydroxysteroid dehydrogenase deficiency (17beta-HSD-3).

    Rabbits do not fall into that strange and rare category of animals that change gender. A rabbit born a buck, will be a buck at 6 months, will be a buck at a year. A rabbit born as a doe will be a doe and 6 months, will be a doe at a year.

    At young ages it can occasionally be difficult for experienced breeders, and even more difficult for inexperienced breeders to sex a rabbit. The majority of “sex changed” rabbits are actually the result of rabbits mis-sexed by the breeder. We have rarely made this mistake. You can usually trust a breeder who has been breeding for several years.

    There are other factors that can contribute to a mis-sexed rabbit. A buck with a split penis will often be sexed as a doe. Using unreliable techniques to determine the gender of a rabbit will often result in mistakes. We will soon have an article on how to properly sex a rabbit.

    The bottom line is that it is genetically impossible for a rabbit to change gender. Next time you hear that, remember, its a rabbit that was not properly sexed.

    Rob Usakowski

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    Source by Rob Usakowski

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  • e-Marketing Strategy: 7 Dimensions to Consider (the e-Marketing Mix)

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    What is e-Marketing?

    e-Marketing is still quite a controversial subject to talk about, since no one succeeded to unify the various theories around it; however there is one thing upon which there is no doubt – that e-Marketing first appeared under the form of various techniques deployed by pioneer companies selling their products via the internet in the early 90’s.

    The frenzy around these new marketing techniques created by e-tailers and supported by the internet rapidly gave birth to a new dimension of what we knew as Marketing: the e-Marketing (electronic Marketing).

    There are many definitions to what e-Marketing is, the simplest and shortest one being formulated by Mark Sceats: e-Marketing is Marketing that uses the internet as manifestation media. A working definition is that coming from a group of CISCO specialists: e-Marketing is the sum of all activities a business conducts through the internet with the purpose of finding, attracting, winning and retaining customers.

    e-Marketing Strategy

    The e-Marketing Strategy is normally based and built upon the principles that govern the traditional, offline Marketing – the well-known 4 P’s (Product – Price – Promotion – Positioning) that form the classic Marketing mix. Add the extra 3 P’s (People – Processes – Proof) and you got the whole extended Marketing mix.

    Until here, there are no much aspects to differentiate e-Marketing from the traditional Marketing performed offline: the extended Marketing mix (4 + 3 P’s) is built around the concept of “transactional” and its elements perform transactional functions defined by the exchange paradigm. What gives e-Marketing its uniqueness is a series of specific functions, relational functions, that can be synthesized in the 2P + 2C+ 3S formula: Personalization, Privacy, Customer Service, Community, Site, Security, Sales Promotion.

    These 7 functions of the e-Marketing stay at the base of any e-Marketing strategy and they have a moderating character, unlike the classic Marketing mix that comprises situational functions only. Moderating functions of e-Marketing have the quality of moderate, operate upon all situational functions of the mix (the classic 4 P’s) and upon each other.

    1. Personalization

    The fundamental concept of personalization as a part of the e-Marketing mix lies in the need of recognizing, identifying a certain customer in order to establish relations (establishing relations is a fundamental objective of Marketing). It is crucial to be able to identify our customers on individual level and gather all possible information about them, with the purpose of knowing our market and be able to develop customized, personalized products and services.

    For example, a cookie strategically placed on the website visitor’s computer can let us know vital information concerning the access speed available: in consequence, if we know the visitor is using a slow connection (eg. dial-up) we will offer a low-volume variation of our website, with reduced graphic content and no multimedia or flash applications. This will ease our customer’s experience on our website and he will be prevented from leaving the website on the reason that it takes too long to load its pages.

    Personalization can be applied to any component of the Marketing mix; therefore, it is a moderating function.

    2. Privacy

    Privacy is an element of the mix very much connected to the previous one – personalization. When we gather and store information about our customers and potential customers (therefore, when we perform the personalization part of the e-Marketing mix) a crucial issue arises: that of the way this information will be used, and by whom. A major task to do when implementing an e-Marketing strategy is that of creating and developing a policy upon access procedures to the collected information.

    This is a duty and a must for any conscious marketer to consider all aspects of privacy, as long as data are collected and stored, data about individual persons.

    Privacy is even more important when establishing the e-Marketing mix since there are many regulations and legal aspects to be considered regarding collection and usage of such information.

    3. Customer Service

    Customer service is one of the necessary and required activities among the support functions needed in transactional situations.

    We will connect the apparition of the customer service processes to the inclusion of the “time” parameter in transactions. When switching from a situational perspective to a relational one, and e-Marketing is mostly based on a relational perspective, the marketer saw himself somehow forced into considering support and assistance on a non-temporal level, permanently, over time.

    For these reasons, we should consider the Customer Service function (in its fullest and largest definition) as an essential one within the e-Marketing mix.

    As we can easily figure out, the service (or assistance if you wish) can be performed upon any element from the classic 4 P’s, hence its moderating character.

    4. Community

    We can all agree that e-Marketing is conditioned by the existence of this impressive network that the internet is. The merely existence of such a network implies that individuals as well as groups will eventually interact. A group of entities that interact for a common purpose is what we call a “community” and we will soon see why it is of absolute importance to participate, to be part of a community.

    The Metcalf law (named after Robert Metcalf) states that the value of a network is given by the number of its components, more exactly the value of a network equals the square of the number of components. We can apply this simple law to communities, since they are a network: we will then conclude that the value of a community rises with the number of its members. This is the power of communities; this is why we have to be a part of it.

    The customers / clients of a business can be seen as part of a community where they interact (either independent or influenced by the marketer) – therefore developing a community is a task to be performed by any business, even though it is not always seen as essential.

    Interactions among members of such a community can address any of the other functions of e-Marketing, so it can be placed next to other moderating functions.

    5. Site

    We have seen and agreed that e-Marketing interactions take place on a digital media – the internet. But such interactions and relations also need a proper location, to be available at any moment and from any place – a digital location for digital interactions.

    Such a location is what we call a “site”, which is the most widespread name for it. It is now the time to mention that the “website” is merely a form of a “site” and should not be mistaken or seen as synonyms. The “site” can take other forms too, such as a Palm Pilot or any other handheld device, for example.

    This special location, accessible through all sort of digital technologies is moderating all other functions of the e-Marketing – it is then a moderating function.

    6. Security

    The “security” function emerged as an essential function of e-Marketing once transactions began to be performed through internet channels.

    What we need to keep in mind as marketers are the following two issues on security:

    – security during transactions performed on our website, where we have to take all possible precautions that third parties will not be able to access any part of a developing transaction;

    – security of data collected and stored, about our customers and visitors.

    A honest marketer will have to consider these possible causes of further trouble and has to co-operate with the company’s IT department in order to be able to formulate convincing (and true, honest!) messages towards the customers that their personal details are protected from unauthorized eyes.

    7. Sales Promotion

    At least but not last, we have to consider sales promotions when we build an e-Marketing strategy. Sales promotions are widely used in traditional Marketing as well, we all know this, and it is an excellent efficient strategy to achieve immediate sales goals in terms of volume.

    This function counts on the marketer’s ability to think creatively: a lot of work and inspiration is required in order to find new possibilities and new approaches for developing an efficient promotion plan.

    On the other hand, the marketer needs to continuously keep up with the latest internet technologies and applications so that he can fully exploit them.

    To conclude, we have seen that e-Marketing implies new dimensions to be considered aside of those inherited from the traditional Marketing. These dimensions revolve around the concept of relational functions and they are a must to be included in any e-Marketing strategy in order for it to be efficient and deliver results.

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    Source by Otilia Otlacan

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  • Sex As a Natural Treatment For Gout

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    I wanted to laugh when I first came across this rather ridiculous suggestion on some of the online sources about natural treatments for gout. After the initial state of skepticism, I decided to do some study about this interesting topic about having sex as a natural treatment for gout.

    Well, it must somehow works on some of the gout patients until this method is widely spread as one of the treatment option for gout. Some people think it works, but they just cannot explain how it works on reducing the inflammation and pain of the notorious gout attacks. Before I explain how to have good sex as one of the method of treating your gout, you must first understand the chemistry of sex.

    We all know about the temptation and good feelings that good sex gives us. That is part of our natural instinct, and having a healthy sex life plays an important role in maintaining the well being of our body and mind.

    Scientists call sex as a melting pot of the soup of bio-chemicals, the hormones. This scientific statement may somehow kills away some of the romantic side of sex, but whatever you feel as the result of sex can actually be explained by simple science. It is not a matter of what happens between your legs, it is about the chemical reactions happen between your ears.

    There are a few vital hormones that contribute the pleasures (and pain relief) we feel during sexual intercourse. It starts with dopamine, which is one of the brain’s pleasure chemicals. Dopamine is released in the ‘reward centre’ of the brain when we see something that arouses our desire, such as good food and attractive partner. Dopamine increases the pulse rate and cardiac functions which result in the ‘blushing’ effect in some people.

    During sexual orgasm, your brain will push the amount of dopamine to the max and then bring it down right after the climax with the release of prolactin which prevents you from over indulge in the rush of dopamine. Prolactin rises sharply immediately after orgasm and it is what gives you the “full” feeling after your intimate moment. Prolactin disengages you from sex after orgasm and makes room for your mind to think of other things besides the naked person lying next to you.

    Beside the roller coaster ride of dopamine, there are two other sex related neurotransmitters that contribute to the whole sensation of sex. Oxytocin, which is also known as the “cuddling hormone” is a hormone secreted by the pituitary gland when you feel the affection to someone you love dearly. Oxytocin helps in creating a strong bond between you and your lover.

    Oxytocin stimulates the production of endorphin which is the ‘happy neuro chemical’ that produces the feelings of ecstasy and pleasure. Endorphins fill you with a sense of well-being and relaxation, and sometimes might even drift you off to sleep. Endorphin has a similar chemical structure of morphine and that explains why it has the pain relief effects.

    The quality of you sex life determine the levels of the above mentions hormones in your body. If you want to have sex as a treatment for gout, you must know how to ‘control’ the release of those hormones.

    The best guideline is to increase the amount of oxytocin and endorphin as much as you can while minimize the fluctuation of dopamine and prolactin. Since oxytocin and endorphin are more emotionally related, so it is good to practice longer lasting sensual experiences with your lover instead of a lustful release of desire.

    Make love, not sex. Those pain and stress relief hormones are hidden in your brain not your sex organ. Cultivate the right feelings and emotions with your love ones by having romantic foreplay and delay the ejaculation for as long as you can while making sure both of you enjoy the pleasure of sex.

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    Source by Heemen Ee

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  • The Best Shingles Diet to Cure Shingles

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    Shingles, medically known as herpes zoster, is a result of the reactivation of the dormant varicella-zoster virus in individuals who have previously had chickenpox. The dormant virus stays in the dorsal root ganglia of the sensory cranial and spinal nerves. When an individual becomes immunocompromised (weakened immune system), the virus is reactivated and comes out in the form of shingles. Shingle flare-ups can become very painful. One way to alleviate shingle flare-ups and to help the immune system fight off the infection is to follow a shingles diet.

    One study about shingles diet suggests that consumption of foods that have a high proportion of lysine to arginine might help reduce the severity or extent of the disease. Arginine and lysine are amino acids; amino acids are what form the protein in the body. The two, however, have different functions. Lysine is gives the raw material needed in the production of collagen. Collagen is responsible for wound healing and plays a part in bone growth. Arginine, on the other hand, is one of the components of nitric oxide. Nitric oxide is important in keeping a healthy and normal blood pressure.

    Arginine is found to encourage the growth of herpes simplex. Lysine, meanwhile, offsets the effects of arginine. Because of these, the two amino acids compete with each other for the absorption of the affected cells. And since the virus which causes herpes simplex and herpes zoster are related, it is believed that a diet consisting of high lysine: low arginine foods can help individuals suffering from shingles as well.

    A shingles diet which contains high lysine includes plenty of meat, fish, and poultry. s. Farm-raised poultry should be preferred than those found in the wild as they contain less arginine and more lysine. Dairy products such as milk, cheese, and yogurt should be included in a shingles diet as they are also rich in lysine. Legumes and soybeans are also great sources lysine.

    Since arginine encourages shingle flare-ups, a shingles diet should comprise of low arginine foods. Some multi-vitamins contain arginine; these kinds of multi-vitamins must be avoided. A shingles diet should also minimize, if not avoid, foods including chocolate, white bread, brewers yeast, nuts, and oats.

    And since shingles is mainly due to poor immune system functions, a good shingles diet must help the immune system fight off the infection. Zinc and Vitamin C are a must in keeping the immune system healthy. Vitamin C is found mainly in fruits and vegetables; oranges, green leafy vegetables, strawberries, potatoes, and peppers are great sources. Zinc, on the other hand, can be found in legumes, whole grains, poultry, red meats, and oysters.

    Proper diet is always a part in the management of any disease. The best shingles diet, consisting of foods rich in lysine, zinc, and vitamin C, should be followed in order to cure shingles faster and to minimize the symptoms of the disease.

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    Source by Bob Carlton

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  • A Review of the Multi Level Marketing International Association Or MLMIA

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    The Multi Level Marketing International Association or MLMIA domain was registered in January of 1997. This is an authority website in the Network Marketing Industry that has been around for a very long time. The website origins seem to originate from Irvine, CA and Las Vegas, NV. However the company says they have been around for the last 25 years although before 1996 they operated primarily offline. They are the official association for Network Marketing Worldwide. Their Goal is to strengthen Multi Level Marketing all over the world.

    The Multi Level Marketing International Association or MLMIA serves its members in all 3 major segments of the Network Marketing Industry. Firstly they serve all Network Marketing Companies who sell goods or services through Distributorships. They also support all Distributors who sell these goods and services. Finally they support all the support companies who provide all these goods or professional services to these two groups just mentioned.

    The MLMIA classifies themselves as a non profit trade organization. Their goal is to keep the Network Marketing Industry clean and are committed to keeping up with the advancements that occur within MLM today. This company has been founded and managed since 1985 by very successful people in Network Marketing. The main goal of the Multi Level Marketing International Association is the protection, support and promotion of individual MLM Opportunities. As a member, their goal is to continually educate you on what it will take to succeed in Network Marketing.

    They do this by providing Advanced Industry Related Education which includes Annual Conferences. A membership with them also includes Authority Articles by some Network Marketing Industry experts. You will also have the opportunity to attend National and International Conferences. This is a great place to network and meet brand new people. This service also offers Industry Trade Shows and will even give you internet exposure. The Multi Level Marketing International Association or MLMIA also works with Accredited Colleges and Universities on the subjects of selling, marketing as well as entrepreneurship.

    Once you get to the MLMIA website, they have a free newsletter you can subscribe to as well as a free audio you can listen to. They also can connect you to resources that will allow you to better compete out there in this tough industry. One of the most exciting functions of this organization is their Annual Convention and Expo which is offered in the spring of each year. Industry participants from all around the world come here to hear about industry trends.

    At the Multi Level Marketing International Association Annual Convention & Expo you Industry Participants will get educated on important topics that will affect your success within the coming year and to network with your peers in a warm, friendly atmosphere. You will be able to grill your fellow Network Marketers and find out what’s working and what’s not working for them.

    People enjoy getting educated by professionals and peers alike. They enjoy motivational messages as well as learning techniques that will increase their techniques by top Distributors around the world. No sponsoring or solicitation is permitted during these events. They also have other upcoming events like their annual Golf Tournament like play and dinner which will only set you back $100.00.

    From what we can see this organization has been around for a while and have definitely put in their stripes. They get the Kings thumbs up and we have nothing but respect for this outstanding organization.

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    Source by Brian Garvin

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