Tag: egg

  • INFOSAN Quarterly Summary, 2020 #1

    Food safety incidents

    During the first quarter of 2020, the INFOSAN Secretariat was involved in 38 food safety incidents involving 109 WHO Member States and 9 territories of WHO Member States. There were 25 incidents involving a biological hazard (Salmonella spp. [8], Listeria monocytogenes [5], Norovirus [3] Shiga-toxin producing Escherichia coli [2], Clostridium botulinum [2] Bacillus cereus [2], Cronobacter spp. [1], Shigella sonnei [1], unspecified biological hazard [1]), 6 involving an undeclared allergen (milk [3], peanut (1), egg [1], gluten [1]), 5 involving a physical hazard (undetermined foreign matter [2], glass [1], metal [1], plastic [1]), one involving a chemical/toxin hazard (histamine), and one linked to an unspecified hazard.

    The food categories that were most commonly involved in the 38 incidents during the first quarter of 2020 involved fish and other seafood (8), herbs and spices (4), legumes and pulses (4), milk and dairy products (3), nuts and oilseeds (3), snacks, desserts and other foods (3), cereals and cereal-based products (2), composite food (2), fruit and fruit products (2), meat and meat products (2), vegetables and vegetable products (2), products of special nutritional use (1), and food for infants and small children (1). One incident involved an unknown food source.

    During such international food safety incidents, the INFOSAN Secretariat relies on the swift action of national INFOSAN Emergency Contact Points to respond to requests for information. Rapid sharing of information through INFOSAN enables members to implement appropriate risk management measures to prevent illness in their respective countries.

    Geographic scope

    The outlined incidents involved Member States from all WHO regions: Europe (39), followed by the Americas (24), Africa (24), the Western Pacific (18), the Eastern Mediterranean (8) and South-East Asia (6).

    Recall in several countries of frozen spring roll sheets from Singapore due to the presence of an undeclared allergen

    In February 2020, the INFOSAN Secretariat was notified by the European Rapid Alert System for Food and Feed (RASFF) and INFOSAN colleagues in Australia of a recall in Australia and several European countries of frozen spring roll sheets due to the detection of an undeclared allergen (milk), imported from Singapore. In collaboration with RASFF, the INFOSAN Secretariat was informed that the implicated frozen spring roll sheets were distributed internationally to 46 Member States from four WHO regions and 4 territories in Europe and the Western Pacific. Moreover, through engagement with the INFOSAN Emergency Contact Point (ECP) in Singapore, the INFOSAN Secretariat also received details of further distribution of implicated products to additional WHO Member States from all WHO regions, taking the total number of Member States involved to 65. It was also reported that the products involved had been redistributed by some countries to Europe, the Americas and Africa. Consequently, several countries recalled the implicated products to relabel them and investigated the issue to identify illnesses related to the consumption of the implicated frozen spring roll sheets. No illnesses were reported to the INFOSAN Secretariat.

    This incident has highlighted undeclared allergens as an important category of hazards that can result in a largescale international response to implement risk management measures and prevent illness. In addition, it exemplified efficient communication among INFOSAN members and the Secretariat.

    Outbreak of Listeriosis in the United States of America linked to enoki mushrooms imported from the Republic of Korea

    In March 2020, the INFOSAN Secretariat was made aware by the United States (US) Centers for Disease Control and Prevention (CDC) of an outbreak of Listeriosis in the US linked to the consumption of enoki mushrooms, imported from the Republic of Korea. In total, 36 cases including 4 deaths have been reported in the US. Following investigations in Canada, carried out in collaboration with the US, the INFOSAN Secretariat was informed of 6 cases of Listeriosis between 2017 and 2019 in Canada potentially related by whole genome sequencing (WGS) to the ongoing outbreak in the USA. In addition, food isolates (from enoki mushrooms from the Republic of Korea) genetically associated with the cluster of cases have been collected in 2019 by authorities in Canada. The WGS information pertaining to the cases and food isolates were shared on the INFOSAN Community Website to assist the identification of cases in other countries.

    The INFOSAN Secretariat engaged the INFOSAN Emergency Contact Point (ECP) in the Republic of Korea to seek details on any further international distribution of the implicated enoki mushrooms. Investigations are ongoing. 

    News & activities

    Food Sector and the COVID-19 outbreak

    On 31 December 2019, WHO was alerted to several cases of pneumonia of unknown origin in the city of Wuhan, Hubei Province, China. The virus, a previously unknown coronavirus has been named SARS-CoV-2 and is the cause of the COVID-19 disease.

    The WHO Epidemic Information Network (EPI-WIN) aims to share information tailored to specific sectors, including food and agriculture. The INFOSAN Secretariat has recently developed a guidance document for food businesses with regards to COVID-19 and food safety which is now available online. The guidance has also been disseminated through EPI-WIN and presented during two webinars.

    Call for applicants: INFOSAN Train-the-Trainer Workshop

    In February, the INFOSAN Secretariat issued a call for applications for the INFOSAN Train-the-Trainer workshop. With the constant growth of the network, and the increased need for training that this entails, the INFOSAN Secretariat, in collaboration with the Canadian Food Inspection Agency (CFIA), has announced this workshop which aims to increase the human resources available to train INFOSAN members on a range of INFOSAN-related topics, online or in-person. As a result, it is expected that the understanding of the roles and responsibilities of INFOSAN members will be improved, resulting in greater participation that will enhance speed and efficiency during the response to food safety emergencies at the global level. The INFOSAN Secretariat, together with CFIA, look forward to hosting this important workshop later this year.

    Developing the new INFOSAN Community Website

    The INFOSAN Community Website (ICW) continues to be an effective tool for the network to disseminate information during food safety emergencies. Over the past year, through the INFOSAN member survey, the Secretariat has gained a better understanding of how members use the ICW and how it can be improved to enhance information sharing. The information collected, together with the experience of members of the Secretariat, has provided numerous innovative ideas to guide the development of the new ICW. The Secretariat is pleased to announce that the competitive process to select the vendor that will develop the new INFOSAN Community Website has concluded and the work on the creation of the new ICW has begun. 

    Voice of an active network member

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  • PHYSIOLOGY OF THE FEMALE SEX ORGANISM

    PHYSIOLOGY OF THE FEMALE SEX ORGANISM

    In the preceding lesson you have been shown “just what” each one of the sex organs of the woman is. In the present lesson you will be shown “just what” each of these organs does—what its functions and offices are. The preceding lesson dealt with the anatomy of these organs; the present lesson will deal with the physiology thereof.

    Beginning with the Ovaries, the fundamental and basic sex organs of the woman, you will have explained to you the wonderful processes performed by each of these organs in turn.

    The Ovaries. The Ovaries in the woman are akin to the testicles in the man. Without the Ovaries there would be no ova or eggs, and without the ova there would be possible no reproductive purposes, and therefore no office for the sex organs at all, for reproduction is the fundamental office, function, and purpose of the entire sexual organism.

    In our consideration of the office, purposes, and functions of the Ovaries, however, we must not overlook a certain secondary phase of such functioning. While it is true that the primary purpose of both the testicles of the male, and the Ovaries of the female, is that of providing seed from which the offspring of the individual may be produced, it is likewise true that there exists a secondary purpose which may be called the “individual” purpose as contrasted with the “racial” and primary one.

    This secondary or “individual” purpose of the Ovaries is that of manufacturing certain secretions which are absorbed by the blood of the woman, and which play an important part in her physical and mental well-being and activities. These secretions begin before puberty in the woman, and continue after her menopause; whereas the manufacture of the ova begins only at puberty, and ceases with the menopause, keeping pace with the manifestation of menstruation in its beginning and its ending.

    Nature provides these chemical secretions from the Ovaries for the purpose of giving the woman her characteristic physical form and contour, her form, her breasts, her long hair, her broad pelvis, her soft voice, and other secondary sex characteristics; and also of providing for the normal development of the other sex organs. As a proof of this statement, science shows us that if a woman’s ovaries are completely removed there is usually a consequent atrophy or “drying up” of the Uterus and the Vagina, and often even of the Vulva. Moreover, the presence of this internal secretion manifests in arousing and maintaining in the woman her normal sexual desire, and her normal pleasure in the company of her mate; it being noted that if the ovaries are removed, particularly in early life, the woman is apt to lose all sexual desire and normal womanly feeling toward the other sex. And, finally, these secretions make for general physical and mental health and well-being in the woman, and contribute to her vivacity, energy, and activity in all directions. As writers on the subject have well pointed out, this is the reason that capable surgeons usually try to leave at least a portion of the Ovaries when performing an operation for the removal of those organs on account of diseased condition.

    The Ovum. The Ovum, or human egg, is a small spherical body, measuring from one two-hundred-and-fortieth to one one-hundred-and-twentieth of an inch in diameter. It has a colorless transparent envelope, the latter enclosing the yolk which consists of granules or globules of various sizes embedded in a viscid fluid. In the center of the yolk is found a very small vesicular body consisting of a tenuous transparent membrane, which is known as “the germinal vesicle;” this, in turn, contains a very tiny granular structure, opaque, of yellow color, known as “the germinal spot.”

    When the time is reached in which the ovum or egg is to be discharged, the Graafian follicle becomes enlarged by reason of the accumulation of the fluids in its interior, and exerts such a steady and increasing pressure from within, outward, that the surrounding tissue yields to it, and it finally protrudes from the Ovary, from whence it is then expelled with a gush, owing to the elasticity and reaction of the neighboring tissues.

    Following this rupture there occurs an abundant hemorrhage from the vesicles of the follicle, the cavity being filled with blood, which then coagulates and is retained in the Graafian follicle. The formation and development of the Graafian follicle begins at puberty and continues until the menopause or “change of life” of the woman. Many follicles are produced, but many do not produce ova, and so gradually atrophy. The ripening and discharge of the eggs produce a peculiar condition of congestion of the entire female sexual organism, including the Fallopian Tubes, the Uterus, the Vagina, and even of the Vulva, which results in a condition of Sexual Excitement. Among the lower animals the female will allow the male to approach her for copulation only at this period, this being the time when the egg is ready for fertilization.

    When the female infant is born, her Ovaries contain the germs of about 100,000 ova. The greater portion of these, however, disappear, until at the time of her puberty the number of germs of ova contains only about 30,000 ova. This number is far more than the woman will ever need, and is Nature’s provision against diseased portions of the Ovaries, accidents, etc. Only one ovum ripens and matures each month from puberty until menopause, so that the woman really requires only about 300 to 350 ova on the average. This liberality on the part of Nature, however, does not begin to approach her lavishness in the case of seed of the male, for in his case while only one spermatozoon is required to fertilize an ovum (and in fact only one is permitted to do so), we find that in each normal act of ejaculation of semen by the male over 250,000 spermatozoa are projected.

    The ripening and discharge of the egg from the Ovaries, and the consequent congestion above referred to, accompanied by what is called Menstruation, occurs regularly each lunar month (28 days). What is called Ovulation consists of the monthly maturing and expulsion of the ripe ovum or egg, while Menstruation (as we shall see later on) consists of the monthly discharge of blood and mucus from the inner surface of the Uterus; the two processes occur in connection with each other, yet neither can be considered as the cause of the other.

    Menstruation. It may be well to call your attention at this point to the process known as Menstruation, or “the monthly flow,” or “the courses” of women. Menstruation is the monthly flow of bloody fluid which occurs in all healthy (non-pregnant) women from puberty to the menopause or “change of life.”

    By “Puberty” is meant the age at which a woman begins her period of possible child-bearing experience. In temperate climates the average age of puberty is about fourteen years, while in tropical countries it is often a year or so earlier, and in arctic countries a year or so later. The time, however, depends materially upon the temperament, race, hygiene, and general environment of the individual girl. At this period the girl gradually changes into the young woman. Her figure changes, her bust develops, her hips broaden, and her mental and emotional nature undergoes a change. Also the menstrual flow begins to manifest at this time; at first scanty and irregular, but gradually changing into the characteristic flow each month.

    At the period of puberty, the girl undergoes marked emotional changes. She becomes very “emotional” as a rule, and quite “sensitive.” She becomes filled with strange, unaccountable longings, ideas, and “notions.” She usually manifests a great emotional interest in her girl friends, and often manifests marked jealousy in connection with these friendships. The girl is apt to indulge in day-dreaming at this period, and becomes quite romantic and “flighty.” She devours love stories, and delights in imagining herself as the heroine of similar adventures. The period from the beginning of puberty to that of the attainment of full sexual maturity is known as the period of “adolescence,” and generally extends to about the age of eighteen in the case of girls.

    By the Menopause is meant that period of the woman’s “change of life,” the average time of which is about the age of forty-five years, although this varies greatly in different individuals. As a rule, it is held that the period of the woman’s child-bearing possibility extends over an average period of thirty years. At the Menopause the woman’s reproductive activity declines and finally ends. The Ovaries diminish in size, the Graafian follicles cease to form and develop; the Fallopian Tubes atrophy; and there occur other physical, mental, and emotional changes in the woman. While the age of forty-five is held to be the average age at which the Menopause occurs in women, still it is not at all uncommon to find women who menstruate regularly up to the age of fifty, or fifty-two, or even fifty-five, while a large number of women menstruate regularly at the age of forty-eight.

    Some women undergo little or no physical or emotional disturbance at the time of the Menopause. In such cases their periods become more or less irregular, with extending intervals between periods; the flow becomes more and more scanty; then several periods are skipped altogether; and finally the periods cease entirely. Other women, however, experience more or less physical disturbance during the years of the “change.” They sometimes experience loss of appetite, or a capricious appetite, headaches, loss of weight, or else a sudden taking on of fatty tissue. They often become quite irritable and “notiony,” and often become quarrelsome and pugnacious, and in some cases manifest unreasonable jealousy. But, in the opinion of many of the best authorities, much of this trouble comes from the mental expectancy of them by the woman, resulting from the notion that a woman must have these things happen to her. The power of the mind over the body is now well known, and we have here another instance of its effect. The remedy is obvious.

    Another matter which disturbs the woman at this time, in many cases, is the common belief that after “the change” she will lose all of her sex attractiveness, and her sexual feelings, etc. This is a grave error, for the experience of all observing physicians is that no such results follow this period of the woman’s life. Many women become even more attractive to the other sex after this time, by reason of acquiring a certain maturity and “ripeness” which proves very attractive to many men—often to young men as well as older ones. Moreover, the sexual desires do not cease with the cessation of the reproductive functions. On the contrary, it often happens that such emotions and desires are increased in the woman at, and after, this time of her life. So true is this that this period has been called “The Dangerous Age” for women, and the experience of many a woman of forty-five to fifty will corroborate this statement. The woman at this time should beware of contracting unwise love affairs and entanglements, and of yielding to impulses toward men other than her mate. A word to the wise should be sufficient in this case.

    To return to the main subject of Menstruation, it may be said that the monthly flow, when once established, occurs at intervals of every twenty-eight days, on the average, although in some individual cases it occurs as often as every twenty-one days, while in others it occurs as seldom as once in every six weeks, all without exceeding the bounds of normal functioning. Menstruation ceases temporarily during pregnancy, in normal cases, and often also ceases during the period of lactation or nursing. The menstrual period lasts on an average for four or five days, the flow increasing for the first half of the period, and decreasing during the last half. At the beginning of the period there is often manifested a general congestion of all of the sexual organs of the woman, and often of the breasts as well. There is also usually found a sense of physical discomfort, from which more or less irritable feeling arises. In rare cases there are found severe cramps and pains, and in some cases the woman finds it necessary to call in medical aid, or to go to bed, or both. In such cases a cure is often worked by improving the general health, and by observing common sense hygienic rules.

    Menstruation is caused by a hypertrophy of the mucus membrane of inner surface of the Uterus, which is followed by a shedding of the hypertrophied membrane. This leaves exposed the underlying vessels, which bleed. New mucus membrane is formed after the period. The menstrual flow consists of a thin, bloody fluid, having peculiar odor, in which is combined blood, thin skin, and mucus membrane, and also mucus from the Uterus and the Vagina, the blood being light in consistency and not clotted.

    During the menstrual period the ovum, or egg, is discharged, and enters the Uterus, as we shall see presently.

    The Life-History of the Ovum. The physiology of the remaining sexual organs of the woman may perhaps best be studied by considering the story of the Life-History of the Ovum, or human egg, for the functions of such organs are concerned with such life-history of the egg, and really exist merely to create such a history, or rather, to produce the process which constitutes the basis of such history.

    The ovum, or egg, when discharged from the ovary, is at first surrounded by a few cells which serve as nourishment, but which soon disappear. It enters the Fallopian Tube and begins its journey toward the Uterus, being urged on its way by the constant movement of the lining-cells of the interior of the tube, in the direction of the Uterus. Certain changes in structure occur. Its passage to the Uterus may be interrupted, and the ovum lost and finally cast off. But the ovum that is successful finally arrives at the Uterus where it awaits impregnation or fertilization by the spermatozoon of the male.

    If copulation occurs within a reasonable time after the arrival of the ovum, it is impregnated or fertilized. Fecundation results and conception ensues, the ovum then remaining attached to the walls of the Uterus, and in time develops into the foetus. If, however, the ovum is not impregnated, because of absence of copulation or from other causes, it gradually loses its vitality, and is finally cast off with the several uterine secretions.

    It should be explained here that the “spermatozoon” of the male (the plural of the term is “spermatozoa”) is the male generative “seed.” The sperum, semen, or seminal fluid of the male is filled with hundreds of thousands of spermatozoa. Each spermatozoon is a minute living, moving creature, resembling a microscopic tadpole. It has a head, a rod-like body, and a thin hair-like tail, the latter being kept in constant motion from side to side, by means of which the tiny creature is enabled to travel rapidly from one point to another. The human spermatozoon measures about one six-hundredth of an inch in length. It is composed of protoplasm, the substance of which all living creatures are composed. The spermatozoa are believed to be developed from a parent sperm-cell, by the process of segmentation or subdivision, which process is common to all cell-life. The numerous spermatozoa dwell in a gelatinous substance, which, mingling with the other fluidic secretions of the glands of the male, constitutes the male seminal fluid, sperm, or semen, which is ejaculated by the male during the process of copulation.

    Fecundation (i. e. fertilization, impregnation; the process by which the male reproductive element is brought in contact with the female ovum or egg) is brought about by the blending of the male reproductive element (or spermatozoon) with the female reproductive element (or ovum, or egg). This blending is of course accomplished by the bringing together in mutual contact the two reproductive elements just mentioned. The sexual act which results in this “bringing together” of the two elements is known as “copulation,” or “coition.” In copulation or coition the seminal fluid of the male, containing an enormous number of spermatozoa, is ejaculated from the male intromittent organ into the receptive canal or channel of the female (the Vagina), and in this way finally comes into actual contact with the female ovum or egg which is awaiting it in the Uterus of the female.

    The spermatozoa (in the process of copulation) are deposited in the Vagina of the female, usually at its upper end, but sometimes in the lower portion; and in rare andpeculiar cases even at or about the Vaginal Orifice or outer vaginal opening. In either case they travel up the remaining portion of the Vagina and finally enter the Uterus or womb. The spermatozoa possess wonderful vitality and power of locomotion. There are cases recorded in which the spermatozoa deposited on or about the outer female genitals have managed to travel inward and upward until they have finally reached the Uterus, where conception has resulted. Such cases, of course, are rare, but they exist, well authenticated and accepted by medical science as facts.

    It must not be supposed, however, that the impregnation of the ovum occurs only in the womb proper. Cases are known in which the spermatozoa have traveled along the Fallopian Tubes and impregnated the ovum there; and in very rare cases the spermatozoon seems to have penetrated even to the Ovary itself, and there impregnated the ovum on the surface of the Ovary. Some excellent authorities, in fact, insist that all normal impregnation occurs at the end of the Fallopian Tube—the point of its entrance into the upper part of the womb, rather than in the body of the womb, or at its mouth, as the older authorities taught. But wherever the actual contact of spermatozoon and ovum occurs, the blending of the elements is performed and fertilization, impregnation, or fecundation is accomplished.

    As a result of copulation, then, the spermatozoon (or a number of spermatozoa) comes in contact with the female ovum or egg. Then one or more of them, by means of a furious lashing of the tiny tail, manages to penetrate the outer covering of the ovum, and enters the space between the outer covering and the real body of the egg. Several spermatozoa may effect an entrance into this outer space, but only one is permitted to enter the real body of the egg. [Twins are produced by the impregnation of two ova by two spermatozoa, at the same time. The presence of the two ova at the same time is unusual]. The moment that the real body of the ovum is penetrated by the successful spermatozoon, a tough covering or thick membrane forms around the ovum and thus prevents the entrance of other spermatozoa. The successful spermatozoon then loses its tail, and the remaining head and body become what is known as “the male pronucleus.”

    The authorities are uncertain as to the exact nature of the change which occurs when the ovum is penetrated by the spermatozoon. The outward manifestations of the change and transformation arising from the blending of the male and female elements are of course well known, but the “life process” eludes the power of the microscope. When Nature forms the thick membranous coating over the impregnated ovum, she draws the veil over one of her most important secrets. The first segmentation-nucleus having been formed by the blending and forging together of the male and female pronuclei, the process of segmentation begins.

    Segmentation proceeds as follows: the impregnated egg splits into halves, forming two joined cells; then into quarters, forming four joined cells; then into sixteenths, then into thirty-seconds, sixty-fourths, and so on, until the ovum consists of a combined mass of very minute granular-like cells, the whole resembling a mulberry. The segmentation of the nucleus precedes and then continues with the segmentation of the yolk. After the egg has been divided into a great number of these cells, the latter begin a centrifugal action resulting in the formation of a complete inner lining of closely packed cells, with a central cavity filled with the yolk liquid.

    In the meantime, the Uterus has been prepared for the reception of the impregnated and transformed ovum. A thick, spongy, juicy, mucus membrane forms, into whichthe changing ovum passes and attaches itself; the mucus membrane soon enveloping it and shutting it off from the rest of the Uterus. There now appears at one point on the ovum an opaque streak, which is called “the primitive trace” of the embryo—the first beginning of the young living creature. The “primitive trace” then grows in length and breadth. At this point we must leave the history of the ovum, or human egg, for the present; its further development will be related in the succeeding lesson, the subject of which is “Gestation.”

    PRIVATE Sex Advice to Women By R. B. Armitage, M. D.

    For Young Wives and those who Expect to be Married.

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