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Making available free paediatric medicine can accelerate elimination of congenital Chagas disease
The donation of an essential antiparasitic medicine can potentially accelerate the elimination of Chagas disease infection in children. A pediatric presentation of benznidazole with accurate dosage and will soon be made available freely to address
a long-standing gap in the treatment of congenital infections of Chagas disease.

The donation, by the Mundo Sano Foundation¹ and INSud Pharma² group to the World Health Organization (WHO), is expected to become effective soon.

“Making benznidazole freely available for the treatment of newborns and children until the age of 19 will be a game-changer in the fight against Chagas disease” said Dr Mwelecele Ntuli Malecela, Director, WHO Department of Control
of Neglected Tropical Diseases. “This can save future generations from developing life-threatening and fatal complications and also boost up diagnosis and treatment contributing to congenital Chagas disease elimination.”

The three-year agreement will make available 108 000 tablets of benznidazole³ – one of the two antiparasitic medicines against Chagas disease. Treatment⁴ with benznidazole in the early stages of infection can cure Chagas
disease, prevent or curb disease progression and prevent congenital transmission in pregnant women.

“We have now added the systematic detection and treatment of all newborns and children under 19 which was not part of our recent switch from control to elimination of congenital Chagas disease” said Dr Pedro Albajar
Vinas, Medical Officer, WHO Department of Control of Neglected Tropical Diseases. “In addition, screening of pregnant women at risk of infection who have not had past antiparasitic treatment provides an excellent opportunity for prevention of posterior transmission throughout pregnancy and birth.”

Each year, an estimated 15 000 children are born from infected mothers.

The agreement

The donation by Mundo Sano Foundation for the duration of the agreement comprises benznidazole:
- 105,000 tablets of 100mg
- 3,000 tablets of 12.5mg
Furthermore, the Foundation may donate funds to support activities associated with distribution of medicines and is ready to consider extending this agreement beyond the specified duration of three years.

The disease

Chagas disease, also known as American trypanosomiasis, is a potentially life-threatening illness caused by the protozoan parasite Trypanosoma cruzi (T. cruzi).

Although considerable progress has been achieved, particularly in reducing vector transmission and screening of blood and organ supply, reaching, diagnosing and providing healthcare for people most affected has been a challenge.

Currently, under-diagnosis of Chagas disease cases is as high as 90% and under-diagnosis of congenital and paediatric cases is believed not to be lower.

Globally, an estimated 6-7 million people are infected with T. cruzi.

The disease is found mainly in endemic areas of 21 continental Latin American countries⁵. But movement of people to urban areas and to other continents has expanded its transmission through non vectorial routes, such as blood transfusion,
congenital transmission, organ transplants and oral transmission through food contamination.

Considering that neglected tropical disease as a growing public health problem in many countries, the World Health Assembly – WHO’s decision-making body – decided in May 2019 to commemorate World Chagas Disease Day on 14 April.

The inaugural celebration happens this year.

¹Mundo Sano is a nonprofit international foundation working with the public and private sectors, academia, and other international organizations to provide solutions to the affected communities and generate scientific knowledge.
In 2012, it led a public-private consortium in 2012 to produce benznidazole in Argentina.

²Insud Pharma (formerly known as Chemo Group) specializes in research, development, manufacture, sale and marketing of active pharmaceutical ingredients and medicinal products for human and veterinary use.

³In 2017, the United States Food and Drug Administration (FDA) approved benznidazole for the treatment of children aged 2–12, making it the first treatment approved in the United States for Chagas disease.

⁴Nifurtimox is also 100% effective in curing Chagas disease if given soon after onset of infection, including cases of congenital infection. It is donated by Bayer who pledged more than 7.5 million tablets for the period 2012-2021.

⁵Argentina, Belize, Bolivia (Plurinational State of), Brazil, Chile, Colombia, Costa Rica, Ecuador, El Salvador, French Guiana, Guatemala, Guyana, Honduras, Mexico, Nicaragua, Panama, Paraguay, Peru, Suriname, Uruguay, and Venezuela
(Bolivarian Republic of).

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https://www.who.int/news-room/detail/02-04-2020-making-available-free-paediatric-medicine-can-accelerate-elimination-of-congenital-chagas-disease

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April 8, 2020
Chagas disease: providing free paediatric medicine can enhance diagnosis and treatment
Documentation resulting in the donation of an important antiparasitic medicine for the treatment of Chagas illness to the World Health Organization (WHO) is within the ultimate stage of preparation.

A 3-year settlement, between the Mundo Sano Foundation¹ (Brazil) and WHO, is anticipated to make obtainable 108 000 tablets of the paediatric formulation of benznidazole² – a first-line medicine towards Chagas illness. Treatment³ with benznidazole within the early levels of an infection can treatment Chagas illness.

“Making benznidazole freely obtainable for the treatment of newborns till the age of 18 might be a game-changer within the battle towards Chagas illness” mentioned Dr Mwelece Ntuli Malecela, Director, WHO Department of Control of Neglected Tropical
Diseases. “This is not going to solely save future generations from growing life-threatening and deadly issues however can even increase up diagnosis and treatment.”

Each yr, an estimated 15 000 youngsters are born from contaminated moms. A freely obtainable paediatric presentation of benznidazole with correct dosage is essentially anticipated to contribute to deal with congenital infections.

“Treating newborns and youngsters was the lacking hyperlink, as we transfer decisively to advocate for the mixing of diagnosis of an infection amongst pregnant ladies and women of child-bearing age into different surveillance programmes, together with HIV and syphilis” mentioned Dr Pedro Albajar Vinas, Medical Officer with WHO’s Department of Control of Neglected Tropical Diseases. “Diagnosing and treating ladies of this age group earlier than being pregnant can increase successfully stop congenital transmission.”

The settlement

The donation by Mundo Sano Foundation at some point of the settlement includes benznidazole:
- 105,000 tablets of 100mg
- 3,000 tablets of 12.5mg
Furthermore, the Foundation might donate funds of as much as US$100 000 at some point of the settlement to help actions related to distribution of medicines and conferences. The Foundation additionally makes provision for an extension of this settlement past
the required length of three years.

The illness

Chagas illness, often known as American trypanosomiasis, is a doubtlessly life-threatening sickness brought on by the protozoan parasite Trypanosoma cruzi (T. cruzi).

Although appreciable progress has been achieved, significantly in decreasing vector transmission and screening of blood and organ provide, reaching and diagnosing individuals most affected has been a problem.

Currently, under-diagnosis of Chagas illness instances is as excessive as 90% and under-diagnosis of congenital transmission is believed to be even greater.

Globally, an estimated 6-7 million individuals are contaminated with T. cruzi.

The illness is discovered primarily in endemic areas of 21 continental Latin American international locations⁴. But motion of individuals to city areas and to different continents has expanded its transmission by means of non vectorial routes, akin to blood transfusion, congenital
transmission, organ transplants and oral meals contamination.

Considering the illness as a rising public well being drawback in lots of international locations, the World Health Assembly – WHO’s decision-making physique – determined in May 2019 to commemorate World Chagas Disease Day on 14 April.

The inaugural celebration occurs this yr.

¹Mundo Sano is a nonprofit worldwide basis working with the general public and personal sectors, academia, and different worldwide organizations to supply options to the affected communities and generate scientific information. In 2012, it led a public-private consortium in 2012 to provide benznidazole in Argentina.

²In 2017, the United States Food and Drug Administration (FDA) accepted benznidazole for the treatment of kids aged 2–12, making it the primary treatment accepted within the United States for Chagas illness.

³ Nifurtimox can be 100% efficient in curing Chagas illness if given quickly after onset of an infection, together with instances of congenital an infection. It is donated by Bayer who pledged greater than 7.5 million tablets for the interval 2012-2021.

⁴ Argentina, Belize, Bolivia (Plurinational State of), Brazil, Chile, Colombia, Costa Rica, Ecuador, El Salvador, French Guiana, Guatemala, Guyana, Honduras, Mexico, Nicaragua, Panama, Paraguay, Peru, Suriname, Uruguay, and Venezuela
(Bolivarian Republic of).

Read More
https://www.who.int/news-room/detail/02-04-2020-chagas-disease-providing-free-paediatric-medicine-can-enhance-diagnosis-and-treatment

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April 3, 2020
Do not take RTK test for Covid-19 without doctor’s advice: MOH

KUALA LUMPUR: The Health Ministry (MOH) has called on the people not to undergo rapid test kit (RTK) tests arbitrarily without seeking the advice of medical practitioners.

Health director-general, Datuk Dr Noor Hisham Abdullah (pix) said it has the potential to a give wrong interpretation from the result obtained.

“The test via RTK technique which is now available in the market is to detect antibodies produced by the body as a result of an infection. The antibodies will appear in the body in five to eight days after infection.

“The RTK test which detects antibodies, cannot detect virus and it is administered for quick confirmation. As such it cannot help in the detection of initial Covid-19 cases. Therefore, RTK test is not recommended for diagnosing Covid-19,” he said in a statement today.

Elaborating further, Dr Noor Hisham said MOH is using the Real-Time Reverse Transcription Polymerase Chain Reaction (rRT-PCR) technique at government health laboratories to detect the presence of Covid-19 virus found in the body of patients.

If the rRT-PCR COVID19 test is found positive, it means the individual has been infected by Covid-19 virus.

“The result of the rRT-PCR technique is very important in managing Covid-19 patients effectively,” he said.

In this regard, Dr Noor Hisham advised the people not to discriminate members of the tabligh congregation following the spread of Covid-19 from the cluster and should in fact assist MOH in tracing close contacts among them.

“We should not blame tabligh members, do not discriminate them, we should not stigmatise the tabligh congregation. What is important is for us to assist, trace and treat Covid-19 infection among tabligh members, their families and their contacts,” he said.

Apart from that. Dr Noor Hisham said KKM is cooperating with MERCY Malaysia to provide psychosocial support to the people especially frontliners and individuals emotionally affected by Covid-19.

They can obtain the service by contacting 011-63996482 / 011-63994236 / 03-29359935 from 8am to 5pm daily.

Members of the public can also contact the virtual health advisory team for a webinar session daily from 9am onwards at http://www.doctoroncall.com.my/coronavirus. – Bernama

Read More
https://www.thesundaily.my/local/do-not-take-rtk-test-for-covid-19-without-doctor-s-advice-moh-IB2175930

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March 24, 2020
A Cardiologist Could Save Your Life

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Everyone has to see a doctor at some point in their lives. Unfortunately there is not one doctor that can diagnose or treat every problem. If you are having any issues or concerns with chest pains, high blood pressure, shortness of breath or issues with your blood vessels your doctor will most likely refer you to a specialist that deals specifically with these types of issues. This specialist is known as a cardiologist and they deal with preventing, diagnosing and treating diseases of the heart and blood vessels.

When you are referred to a cardiologist you can be sure that you are seeing a doctor who is highly trained in a very specific area. These doctors have an extensive educational background which includes four years of medical school and three years of training in general internal medicine. Following that they will spend another three years or more in specialized training. In order for these doctors to become certified they must have completed a minimum of ten years clinical and educational training and then pass a two-day exam that is administered by the American Board of Internal Medicine.

There are a variety of reasons that your doctor might refer you to a cardiologist. If there is any suspicion that you might have a significant heart or related condition you are a good candidate for a referral. Some patients that have heart murmurs or any signs of change in their ECG will also be good candidates for a referral. These doctors will be involved in the treatment of any heart attack, heart rhythm disturbances or heart failure. They are also very involved in helping patients who are affected by heart disease return to a normal life and they counsel patients about the risks as well as the prevention of heart disease.

Every patient has a different experience with a cardiologist. All patients will be required to undergo an initial consultation where the doctor will review their medical history and perform a physical examination. This examination may be a little more in-depth than what patients are used to and may include such things as having their blood pressure, weight, heart, lungs and blood vessels checked. Depending on the patient’s symptoms and the doctor’s findings on the examination a diagnosis may be made at that point. In some cases additional testing such as an ECG, x-ray or blood test may be required in order to make a definitive diagnosis. Pending the results and diagnosis the doctor may recommend medication or some lifestyle changes.

For some people the thought of going to a doctor is scary at any age. The thought of being referred to a specialist may be even more frightening for some people. It is important to remember that your doctor would not make a referral to a specialist unless they truly thought it was necessary. It is always better to be cautious and if there are any concerns about issues pertaining to the heart you definitely want to be in the hands of an experienced cardiologist.

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Source by Aloysius Aucoin

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January 31, 2020
Physical Therapy and Sports Medicine – Know the Differences

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It isn’t unusual to use the terms sports medicine and physical therapy interchangeably. However the two aren’t exactly the same things even though you may find yourself the patient of both fields at the same time.

While compatible, the difference between the two branches of medical discipline is clear. Both are effective for treating injuries, diseases and disorders of the muscle and skeletal systems of the body and both are useful for the prevention of future injury or disease symptom reoccurence. By taking an individual look at both types of medical assistance, you will soon see the differences between physical therapy and sports medicine.

Let’s take a look at the field of physical therapy first. Unlike sports medicine, physical therapy as a whole is devoted to correcting any injury, disease, or disorder of the bones and muscles that can be treated with non invasive techniques. The focus is to provide patients with relief from pain, improve their muscle, joint, and bone function, while providing techniques the patient can use on their own for additional healing. The primary tools of a therapist are good diagnosing and evaluating skills, knowledge of the musculoskeletal system, and knowledge of which therapy is effective for each situation.

One large difference between the two is that physical therapy doesn’t only deal with sports related injuries or problems. Physical therapists can choose to specialize in their careers with emphasis on things like pediatrics, geriatrics, and neurology. Other areas of expertise included in physical therapy are sports, cardiovascular sciences, and occupational therapy.

When you are looking at the differences between these two healing arts you certainly can’t overlook sports medicine. The type of medical discipline is solely used for sports related injuries and disorders. While sports physical therapy techniques are commonly used in addition to sports medicine, sports medicine may involve surgeries, procedures, and medications not used in physical therapy. Sports medicine practitioners also can have specialty fields as well. Orthopedics and skeletal emphasis are common. Advanced study of how long term sporting activities and treating sports related injuries are always a part of this particular discipline.

Understanding the difference between physical therapy and sports medicine may be key to determining how to best treat your physical problem. While they can and are commonly used together, each one has its own distinct benefit. Your medical care team can further help distinguish the two and point you in the right direction in terms of your health care needs. The important thing is take care of any injury, sports related or not, to ensure your body’s function in the years to come.

The difference between these two medical approaches is obvious. Although the two are often used together, each one has its own purpose and uses. Your doctor can give you advice on which specialist is right for your needs.

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Source by John Groth

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January 5, 2020
Diagnosing Fibromyalgia: Tests Your Doctor Should Run in the Course of Your Treatment

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Fibromyalgia is often missed or misdiagnosed for a number of reasons. There aren’t definitive blood tests or X-ray to diagnose Fibromyalgia and it shares symptoms with many other diseases and conditions.

Diagnosing Fibromyalgia is a combination of taking the patient’s symptom history, a physical exam testing the Patient’s Trigger Points and exclusion.

Today I’m going to focus on the exclusion portion of diagnosing Fibromyalgia. Sometimes people are diagnosed with Fibromyalgia because their doctor failed to run the necessary tests to uncover a different, and perhaps serious condition.

If you feel terrible and are experiencing a variety of symptoms common to Fibromyalgia, you are going to go to your doctor.

After taking your history, your doctor is going to want to run some tests to begin excluding diseases.

What Diseases & Conditions Should Your Doctor Test for when Diagnosing Fibromyalgia?

The following diseases & conditions share some of the symptoms of Fibromyalgia and they should be excluded. Sometimes doctors who aren’t as familiar with Fibromyalgia fail exclude some of these serious and life threatening diseases. You have every right as a patient to ask your doctor to test you for all of the following:

Diabetes

Easily tested for with a blood test

Chronic Fatigue Syndrome

There isn’t currently a blood test for this condition, however they recently discovered that CFS is caused by an autoimmune virus and I suspect there will be a blood test forthcoming. Talk to your doctor about Chronic Fatigue Syndrome.

Hepititis B & C

Easily tested for with a blood test

Lyme Diseases

Doctors often overlook Lyme Disease and do not test for it. This is an oversight on their part and you should ask to be tested.

Lupus

There isn’t a definitive test for Lupus however your doctor should run a ANTI NUCLEAR ANTIBODY Test. If you have high autoimmune activity in your blood (a trait of Lupus), this test will detect it.

Multiple Sclerosis

MS is also difficult to diagnose, however they do use MRI to test for MS. While you shouldn’t run off and get an MRI just yet, talk to your doctor about Multiple Sclerosis.

Rhuematoid Arthritis

Easily tested for with a blood test

Sjogrens Autoimmune Disorder

Easily tested for with a blood test

Thyroid Disease

Most doctors only test your thyroid with a THYROID STIMULATING HORMONE Test. However, you might have a thyroid issue even if your thyroid is functioning properly – I do! Fibromyalgia Patient’s often have thyroid issues in conjunction with Fibromyalgia so running in depth tests is a must. Ask your doctor to run the following tests:

FREE THYROXINE LEVELS

T3 and T4

ANTI THRYOGLOBULIN ANTIBODY

ANTI THRYOGLOBULIN ANTIBODY

Other Blood Tests Your Doctor Should Run for a Fibromyalgia Diagnosis:

CBC: Checks your Complete Blood Count. Looking for issues such as anemia and other diseases.

COMPREHENSIVE METABOLIC PANEL: Tests your kidney, liver and overall health.

HEME PROFILE + ELECT DIFF: Checks for unusual activity in your white or red blood cells.

FOLATE: If not included in your CBC, checks your folate levels.

SEDIMENTATION RATE: Checks for inflammation in your body

SERUM PROTEIN ELECTROPHORESIS:Tests for autoimmune diseases

VITAMIN B12:Checks your B12 levels if not done in your CBC.

VITAMIN D: Checks your D levels. Vitamin D is the Sunshine Vitamin. Ask your doctor to run the Vitamin D test that checks both your D3 and D2 levels. This is a hot topic because scientists are re-evaluating what they previous believes. Research is showing that while your combined D level is within normal range if your D3 and D2 levels might be individually low and this could be an issue. (My D2 is zero).

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Source by Margo Watson

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December 30, 2019