Tag: Delivery

  • Socso’s PSP for Covid-19 screening : Only RT-PCR tests will do

    Socso’s PSP for Covid-19 screening : Only RT-PCR tests will do

    Socso’s PSP for Covid-19 screening : Only RT-PCR tests will do 1

    KUALA LUMPUR: The Social Security Organisation will only accept the ‘Reverse Transcriptase-Polymerase Chain Reaction’ (RT-PCR) method for Covid-19 screening under its Program Saringan Prihatin (PSP) initiative and not the ‘Rapid Test Kit (RTK) Antibody’ methodology.

    Socso said it was taking this measure based on the latest guidelines from the Health Ministry (KKM) on Covid-19 screening which only recognises RT-PCR as the methodology and the National Security Council’s decision on the same matter.

    “Socso views the recommendation on the Covid-19 screening methodology for workers at high risk very seriously, The screening tests will be undertaken by the existing service providers and also others who will be appointed to enable more efficient delivery.

    “This screening is compulsory for foreign workers in the construction sector or those working in red zones only,” Socso said in a statement here today.

    Prior to this, Socso had announced that under its PSP initiative on testing for Covid-19 on workers of companies operating during the Movement Control Order (MCO) period would entail two phases namely RT-PCR followed by the RTK Antibody.

    Socso will be providing more information at its Portal Prihatin Perkeso at https://prihatin.perkeso.gov.my. –Bernama

    Socso’s PSP for Covid-19 screening : Only RT-PCR tests will do
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    https://www.thesundaily.my/home/socso-s-psp-for-covid-19-screening-only-rt-pcr-tests-will-do-EK2387017

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  • Compendium of research projects at the interface of tuberculosis and COVID-19

    As the world comes together to tackle the COVID-19 pandemic, it is important to ensure that tuberculosis (TB) prevention and care approaches are adapting appropriately to ensure continuous and safe delivery of high-quality TB services. Considering the overlaps in TB and COVID-19 in disease presentation and transmission, the pandemic presents many questions for the TB field that may require learning through research and innovation. 

    To better understand challenges and opportunities in this space, the World Health Organization Global TB Programme is collating information on ongoing research at the interface of TB and COVID-19 (i.e. research which would improve TB prevention and care approaches in the context of the COVID-19 pandemic). We are developing a living compendium (listing), which will be updated periodically to make ongoing research projects and publications visible on its website. With your consent we would like to include any study you have in this compendium.

    To fulfill these objectives, we need the cooperation of organizations and individuals engaged in TB/COVID-19 research to complete this  one page template before 20 May 2020. We encourage you to please share this in your network, so we can reach all stakeholders widely.

    We thank you in advance for your cooperation, and please do not hesitate to contact us if you have any questions.

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    https://www.who.int/news-room/detail/04-05-2020-compendium-of-research-projects-at-the-interface-of-tuberculosis-and-covid-19

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  • Massive proportion of world’s population are living with herpes infection

    Massive proportion of world’s population are living with herpes infection

    Virus causing genital herpes may put millions of people at greater risk of infection with HIV

    About half a billion people worldwide are living with genital herpes, and several billion have an oral herpes infection, new estimates show.

    Authored by staff at the University of Bristol, World Health Organization (WHO), and Weill Cornell Medical College-Qatar, and published in the Bulletin of the World Health Organization,
    the new study estimates the global infection prevalence and incidence of herpes simplex virus types 1 and 2 (HSV-1 and HSV-2) in 2016. 

    “Herpes infection affects millions of people across the globe and can have far-reaching health effects. We need more investment and commitment to develop better treatment and prevention tools for this infection.” says Dr Sami Gottlieb, Medical
    Officer at WHO and an author of the study.

    Prevalence and incidence

    An estimated 491.5 million people were living with HSV-2 infection in 2016, equivalent to 13.2% of the world’s population aged 15 to 49 years. HSV-2 is almost exclusively sexually transmitted, causing infection in the genital or anal area (genital
    herpes).

    An estimated 3.7 billion people had HSV-1 infection during the same year – around 66.6% of the world’s population aged 0 to 49. HSV-1 is mainly transmitted by oral to oral contact to cause infection in or around the mouth (oral herpes). However,
    HSV-1 can also be transmitted to the genital area through oral-genital contact – during oral sex – to cause genital herpes. Most HSV-1 infections were oral; however, between 122 million to 192 million people were estimated to have genital
    HSV-1 infection, depending on the assumptions used in the estimation model.

    Because herpes is a lifelong infection, estimated prevalence increased with age; HSV-2 prevalence was also higher among women and in the WHO African Region.

    Health and social impacts

    Most people living with herpes, caused by either HSV-1 or 2, are unaware they have the infection.

    When symptoms do occur however, oral herpes infection can lead to painful sores around the mouth (“cold sores”). Genital herpes infection can cause recurring, often painful, genital sores, often referred to as genital ulcer disease. 

    WHO and partners published a study in March 2020 estimating that around 5% of the world’s population (187 million people) suffered from at least one episode of herpes-related genital ulcer disease in 2016 (1). Most of these episodes were due to
    HSV-2, which can recur frequently over many years.

    Recurrent symptoms of genital herpes can lead to stigma and psychological distress, and can have an important impact on quality of life and sexual relationships. However, in time, most people with herpes adjust to living with the infection.

    “Genital herpes is a substantial health concern worldwide – beyond the potential pain and discomfort suffered by people living with the infection, the associated social consequences can have a profound effect on sexual and reproductive health”
    says Dr Ian Askew, Director of the Department of Sexual and Reproductive Health and Research at WHO. 

    Herpes and HIV

    A strong association exists between HSV-2 infection and HIV infection. In 2019, WHO commissioned a modeling study to estimate how much HSV-2 infection might contribute to HIV incidence. The study estimated that almost 30% of new sexually acquired HIV
    infections in 2016 worldwide were likely attributable to HSV-2 infection (2). 

    Evidence shows that people with HSV-2 infection are at least three times more likely to become infected with HIV, if exposed. HSV-2 leads to inflammation and small breaks in the genital and anal skin that can make it easier for HIV to cause infection.
    In addition, people with both HIV and HSV-2 infection are more likely to spread HIV to others.

    Women have higher biologic susceptibility to both HSV-2 and HIV. Women living in the WHO Africa Region have the highest HSV-2 prevalence and exposure to HIV – putting them at greatest risk of HIV infection, with negative implications for their health
    and well-being. 

    For people living with HIV (or who are living with other conditions that compromise their immune systems) as well as HSV-2, the symptoms of herpes can be more severe and more frequent. 

    Neonatal herpes

    Neonatal herpes can occur when an infant is exposed to HSV in the genital tract during delivery. This is a rare condition, occurring in an estimated 10 out of every 100,000 births globally, but can lead to lasting neurologic disability or death. The risk
    for neonatal herpes is greatest when a mother acquires HSV infection for the first time in late pregnancy. Women who have genital herpes before they become pregnant are at very low risk of transmitting HSV to their infants.

    No cure – better treatment and prevention needed

    There is no cure for herpes. At present, antiviral medications, such as acyclovir, famciclovir, and valacyclovir, can help to reduce the severity and frequency of symptoms but cannot cure the infection.

    As well as increasing awareness about HSV infection and its symptoms, improved access to antiviral medications and heightened HIV prevention efforts for those with genital HSV symptoms are needed globally. 

    In addition, development of better treatment and prevention interventions is needed, particularly HSV vaccines. WHO and partners are working to accelerate research to develop new strategies for prevention and control of HSV infections. Such research includes
    the development of HSV vaccines and topical microbicides. Several candidate vaccines and microbicides are currently being studied.

    “A vaccine against HSV infection would not only help to promote and protect the health and well-being of millions of people, particularly women, worldwide – it could also potentially have an impact on slowing the spread of HIV, if developed
    and provided alongside other HIV prevention strategies” says Dr Meg Doherty, Director of the WHO Department of Global HIV, Hepatitis, and STI Programmes.

    Related publications

    WHO guidelines for the treatment of Genital Herpes Simplex Virus

    WHO preferred product characteristics for herpes simplex virus vaccines

     

    ———————-

    (1) Looker KJ, Johnston C, Welton NJ, et al. The global and regional burden of genital ulcer disease due to herpes simplex virus: a natural history modelling study. BMJ Glob Health. 2020;5(3):e001875. doi: 10.1136/bmjgh-2019- 001875.

    (2) Looker KJ, Welton NJ, Sabin KM, et al.Global and regional estimates of the contribution of herpes simplex virus type 2 infection to HIV incidence: a population attributable fraction analysis using published epidemiological data. Lancet Infect Dis.2020;20(2):240-249. doi: 10.1016/S1473-3099(19)30470-0.

    Massive proportion of world’s population are living with herpes infection
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    https://www.who.int/news-room/detail/01-05-2020-massive-proportion-world-population-living-with-herpes-infection

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  • New GDO country profiles available

    New GDO country profiles available

    Countries across the six WHO regions are participating in the Global Dementia Observatory (GDO), a data and knowledge exchange platform. The GDO provides easy access to country-level key dementia data and functions as the monitoring mechanism of the Global dementia action plan on the public health response to dementia 2017-2025.

    GDO country profiles offer a baseline summary of countries’ progress on dementia actions outlined in the global dementia action plan. They provide an easy read snapshot of the more comprehensive data submitted by Member States across three key domains related to dementia: policies, service delivery, and information and research. GDO country profiles can be used to inform policy, service planning and health and social care systems decisions for dementia. Additional country profiles will be added as data becomes available.

     

    View GDO country profiles

    Access the GDO

    Read the GDO Reference Guide

    New GDO country profiles available
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    https://www.who.int/news-room/detail/28-04-2020-GDO-country-profiles

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  • Commitment and call to action: Global collaboration to accelerate new COVID-19 health technologies

    Commitment and call to action: Global collaboration to accelerate new COVID-19 health technologies

    Our Vision and Mission

    Grounded in a vision of a planet protected from human suffering
    and the devastating social and economic consequences of
    COVID-19, we, an initial group of global health actors (BMGF,
    CEPI, Gavi, Global Fund, UNITAID, Wellcome Trust, WHO) and
    private sector partners and other stakeholders, are launching
    a landmark, global and time-limited collaboration to accelerate the
    development, production and equitable global access to new COVID-19 essential health technologies.

    We know that as long as anyone is at risk from this virus, the entire
    world is at risk – every single person on the planet needs to be
    protected from this disease.

    We agree that alongside evidence-based public health measures,
    innovative COVID-19 diagnostics, therapeutics and vaccines are
    needed – in record time and at record scale and access – to save
    millions of lives and countless trillions of dollars, and to return
    the world to a sense of ‘normalcy’.

    We recognize the significant amount of critical work, investment
    and initiatives already ongoing around the world to expedite
    the development and deployment of innovative COVID-19 related
    products and interventions.

    We appreciate that while development and deployment of
    innovative products is essential, it will not be enough. We must
    simultaneously and urgently accelerate the strengthening of
    sustainable health systems and capacities to enable delivery of
    the new COVID-19 tools to those who need them and to mitigate
    the knock-on impact on other diseases.

    We remember lessons from the past, which have shown that even
    when effective tools are available to the world, too often some
    are protected, while others are not. This inequity is unacceptable –
    all tools to address COVID-19 must be available to all. In the fight
    against COVID-19, no one should be left behind.

    We understand we cannot do this alone, and that we need to
    work together in unprecedented and inclusive partnership with all
    stakeholders – political leaders, public and private sector partners,
    civil society, academia, and all other stakeholders across society
    – jointly leveraging our comparative strengths and respective
    voices to drive towards collective solutions, an accelerated path,
    and access for all. We are stronger, faster and more effective
    working together.

    Our Mission is not only accelerated development and availability
    of new COVID-19 tools – it is to accelerate equitable global access
    to safe, quality, effective, and affordable COVID-19 diagnostics,
    therapeutics and vaccines, and thus to ensure that in the fight
    against COVID-19, no one is left behind.

    Our Commitment

    1. We commit to the shared aim of equitable global
      access to innovative tools for COVID-19 for all.
    2. We commit to an unprecedented level of partnership
      – proactively engaging stakeholders, aligning and
      coordinating efforts, building on existing collaborations, collectively devising solutions, and grounding
      our partnership in transparency, and science.
    3. We commit to create a strong unified voice to
      maximize impact, recognizing this is not about
      singular decision-making authority, but rather
      collective problem-solving, interconnectedness and
      inclusivity, where all stakeholders can connect and
      benefit from the expertise, knowledge and activities
      of this shared action-oriented platform.
    4. We commit to build on past experiences towards
      achieving this objective, including ensuring that
      every activity we undertake is executed through the
      lens of equitable global access, and that the voices
      of the communities most affected are heard.
    5. We commit to be accountable to the world, to
      communities, and to one another. We are coming
      together in the spirit of solidarity, and in the service
      of humanity, to achieve our mission and vision.

    Our Call

    We ask the global community and political leaders to
    support this landmark collaboration, and for donors to
    provide the necessary resources to accelerate achievement
    of the objectives of this global collaboration, capitalizing
    on the opportunity provided by the rolling pledging
    campaign that will start on 4 May 2020.

    Commitment and call to action: Global collaboration to accelerate new COVID-19 health technologies
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    https://www.who.int/news-room/detail/24-04-2020-commitment-and-call-to-action-global-collaboration-to-accelerate-new-covid-19-health-technologies

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  • Hard fought gains in immunization coverage at risk without critical health services, warns WHO

    Hard fought gains in immunization coverage at risk without critical health services, warns WHO

    Shutting down immunization services in the COVID-19 pandemic risks triggering a resurgence of diseases that can be prevented with safe and effective vaccines, warns WHO in the lead-up to World Immunization Week (24-30 April). 

    When immunization services are disrupted, even for brief periods during emergencies, the risk of vaccine-preventable disease outbreaks, such as measles and polio, increase. Last year’s deadly measles outbreak in the Democratic Republic of the
    Congo, which took more than 6000 lives in a country already facing its largest Ebola outbreak, highlights the importance of maintaining essential health services, such as immunization in times of emergency. Further disease outbreaks will also overwhelm
    health systems already battling the impacts of COVID-19.

    “Disease outbreaks must not remain a threat when we have safe and effective vaccines to protect us,” said Dr Tedros Adhanom Ghebreyesus, WHO Director-General. “While the world strives to develop a new vaccine for COVID-19 at record speed,
    we must not risk losing the fight to protect everyone, everywhere against vaccine-preventable diseases. These diseases will come roaring back if we do not vaccinate.”

    WHO is working with partners all over the world to accelerate research and development of a safe and effective vaccine and ensure equitable access for the billions of people who will need it.

    But even with an expedited process, development of a vaccine for COVID-19 will take time. Precautionary measures are essential now to help keep us safe from disease, including diseases for which vaccines already protect children and adults.

    Too many people are still excluded from the benefits of vaccines

    Prior to the COVID-19 pandemic, the world had made immense progress in ensuring that children are vaccinated. In 2018, 86 percent of children under the age of five globally were vaccinated with three doses of diphtheria, tetanus and pertussis (DTP3) and
    one dose of the measles vaccine, up from 72 percent in 2000 and 20 percent in 1980. The number of children paralyzed by polio has been reduced by 99.9 percent worldwide. 

    Yet, global vaccination coverage is still far from the 95 per cent coverage needed to fully protect communities against outbreaks of this vaccine-preventable disease. 

    In 2018 nearly 20 million children worldwide – more than 1 in 10 – missed out on lifesaving vaccines, such as measles, diphtheria and tetanus. Roughly, 13 million of the children have never received any vaccines, putting them and their communities
    at risk of disease and death. The majority of these children live in countries with already fragile health systems, further limiting their access to essential health services when they fall sick.

    Measles continues to remain an ever-present threat, especially if vaccination rates drops. Current projections indicate that the number of reported measles cases for 2019 will be at least 800 000. In 2020 there are increasing concerns about another
    resurgence, especially if vaccination rates fall due to delay or suspension of scheduled immunization activities as a result of COVID-19. 

    Outbreaks of polio, diphtheria and yellow fever are also of high concern, especially in the countries least able to respond quickly and decisively to address an emerging outbreak, as seen in previous emergencies such as the polio outbreak in Syria in
    2013. 

    Maintaining immunization services during COVID-19

    As the response to COVID-19 continues, countries must act now protect immunization services, in order to further minimize disease outbreaks and loss of life. This includes, facilitating urgent catch up programmes in places where
    services have been disrupted, ensuring strong supply chains, disease surveillance and trained health workers. Caregivers should also make sure they continue to vaccinate their children in line with national policies.

    New WHO guidelines on immunization and COVID-19 recommend that governments temporarily pause preventive immunization
    campaigns where there is no active outbreak of a vaccine-preventable disease. But it urges countries prioritize the continuation of routine immunization of children in essential service delivery, as well as adult vaccinations such as influenza
    for groups most at risk. If immunization services must be suspended, urgent catch-up vaccinations should be rescheduled as soon as possible, prioritizing those most at risk.

    Hard fought gains in immunization coverage at risk without critical health services, warns WHO
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    https://www.who.int/news-room/detail/23-04-2020-hard-fought-gains-in-immunization-coverage-at-risk-without-critical-health-services-warns-who

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  • Choosing the Right Email Service Provider

    Just as email marketing can be complex, so is choosing a top tier ESP (Email Service Provider). Comparing ESPs to each other isn?t always an apples-to-apples comparison. They each have their specific areas of strengths and weaknesses. For example, some ESPs excel at integration with web analytics or CRM (Customer Relationship Management) systems, some are very strong in deliverability, and others have a more intuitive interface. The differences don?t just stop there: The same piece of content sent to the same list on different ESPs will give you different delivery results.

    This white paper will help you narrow down the services that are most important to you and what to look for when selecting an ESP. It also includes an ESP Scoring Sheet!

    Read More
    http://www.associationofmarketing.org/whitepapers/view.php?whitepaper_id=72

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  • GESTATION OR PREGNANCY

    GESTATION OR PREGNANCY

    Gestation is “the act of carrying young in the Uterus, from the time of conception to that of parturition.” Conception occurs at the moment of the impregnation of the ovum; parturition is the act of delivery, or childbirth. Pregnancy is “the state of being with child.” The terms “period of gestation,” and “period of pregnancy,” respectively, are employed by medical authorities to designate the time during which the mother carries the young within her own body—from the moment of the impregnation of the ovum until the moment of the final delivery of the child into the outer world.

    The term of pregnancy in woman continues for over nine calendar months (or ten lunar months)—from about 275 to 280 days, though in exceptional cases it may be terminated in seven calendar months, or on the other hand may continue for ten calendar months. The usual method is to figure 280 days from the first day of the last menstruation. A simple method of calculating the probable date of delivery is as follows: Count back three months, and then add seven days, and you will have the date of probable delivery. Example: A woman’s first day of last menstruation is March 28. Counting back three months gives us December 28; and adding seven days to this gives us January 4, as the date of probable delivery. There will always be a possible margin of a few days before or after the ascertained probable date—but the delivery will very closely approximate said date. Ignore the shortage of days of February in this calculation, the same being covered by the general margin allowed.

    Development of the Impregnated Ovum. In the preceding lesson we terminated our consideration of the impregnated ovum at the point at which, after the process of segmentation, the “primitive trace” had appeared. This primitive trace appears as an opaque streak, or straight line, formed of an aggregation of cells of a distinctive quality. This delicate “trace” or “streak” is the first indication of the form of the coming child. It is the basis, pattern, or mould, in or around which the spinal column is to be formed, and around which the entire young body is to be developed by the wonderful and intricate processes of dividing and reduplication, and the folding and combination of cells. From one end of this “trace” develops the head; from the other end develops the lower end of the spine. At a later stage there appear tiny “buds” in the positions at which the arms and legs should be; these gradually develop, and their ends split into tiny fingers and toes, and finally are transformed into perfect little arms and legs, miniatures of those of the adult human being.

    The term “the embryo” is employed to designate the developing young creature in the earlier stages of its development, particularly before the end of the third month of its existence. After the end of the third month the embryo is called “the fetus.” In the short space of 280 days the young creature evolves and develops from a single simple cell into a complex organism—a perfect miniature human being. Nature works a wonderful miracle here, and yet so common is it that we take it all as a matter of course, and lose sight of the miracle. From the most simple forms are formed in the developing creature the most complex organs and parts. The heart is formed from a tiny straight line of cells, by enlargement and partition. The stomach and intestines, likewise, develop from a tiny straight line of cells arranged as a tiny tube—the stomach is formed by dilation of one part of the tube, while the large intestine experiences a similar though lesser distention and a greater growth in length; the smaller intestines being formed by growth in length and circumference. The other organs evolve from similar simple beginnings.

    The embryo is nourished during its earlier stages by means of the “yolk sack,” or “umbilical vesicle,” which is outside the body of the embryo, being joined to it by means of the umbilical duct. This yolk sack (originally formed by a “drawing together” in the ovum, which thus separates itself into two portions or areas) is an important feature of the life of the embryo, as it nourishes and sustains it in its earlier stages. Blood vessels form in this yolk sack, and after a time its fluid is absorbed, and after the third month the sack gradually disappears.

    After the passing away of the yolk sack, the embryo is nourished and sustained by the “allantois,” another peculiar sack which is formed. This sack readily becomes filled with blood-vessels, and serves to nourish the embryo by sustenance obtained from the body of the mother through the walls of the Uterus, a direct communication with the blood-vessels of the mother thus being secured. The blood in the embryo, and that in the mother, come into close contact, thus allowing the embryo to be nourished by the blood of the mother. After a time, in turn, the allantois diminishes and dwindles away, its offices being taken up and performed by the “placenta” or “afterbirth.”

    The Placenta or Afterbirth. The Placenta, or afterbirth, is a round, flat substance or organ, contained within the Uterus, by which communication and connection is established and maintained between the fetus and the mother, by means of the umbillical cord. It is a flat, circular mass, about seven inches in diameter, and weighing about sixteen ounces. It is attached to the sides of the Uterus of the mother during the period of gestation, and is expelled from the body of the mother, as “the afterbirth,” after the birth of the child.

    Let us pause a moment, and reconsider the several steps in Nature’s plan for nourishing the embryo and fetus. In the first place, as we have seen, there is the yolk sack or umbillical vesicle, filled with a fluid which nourishes the embryo. This gradually disappears in time, and is replaced by the “allantois” which by connection with the walls of the Uterus is enabled to nourish the fetus from and by the blood of the mother. For a short time, however, the embryo is nourished by both the yolk sack and the allantois. Then the allantois assumes the entire task, and the yolk sack passes away. Then, later, the placenta replaces the allantois, and the latter passes away as did its predecessor. The placenta works along the same general lines as the allantois, but is a far more complex way and with a much higher degree of efficiency, as we shall see presently.

    The placenta is connected with the body of the fetus by what is known as “the umbillical cord.” The “umbillicus” or “navel” in the human being marks the place at which the umbillical cord entered the body of the fetus, from which it was severed after the birth of the child. The purpose of the umbillical cord is to contain and support the umbillical arteries and veins through which the fetus obtains nourishment from the placental substance, and through which the return blood flows. The rich red arterial blood is carried from the placenta to the fetus, and is then distributed over the body of the fetus, nourishing and building it up; the dark venous blood, laden with the waste products of the body of the fetus, is carried back to the placenta, there to be repurified and rendered again rich and nourishing.

    The story of the circulation of the blood of the fetus is most interesting. Although the fetal blood is derived from that of the mother, as we have said, yet the maternal blood does not pass directly from the circulatory system of the mother into that of the fetus; nor does the blood of the fetus return directly into the circulatory system of the mother. In fact, the fetal blood never comes in direct contact with that of the mother, or vice versa. The fetus has an independent circulatory system of its own, and yet, at the same time, from the moment of the placental connection until the moment of childbirth, all its nourishment is derived from its mother.

    The secret of the above paradoxical statement is made apparent when we understand the meaning of the scientific term “osmosis.” Osmosis is “the passage of a fluid through a membrane”; it is a chemical process, caused by the chemical affinity between two liquids or gases separated one from the other by a porous diaphragm or substance. In the process of osmosis in the case before us, the fetal blood takes up nourishing substances and oxygen from the blood of the mother, and passes on to the latter the waste products of the fetal system, by means of passing these substances through the thin porous membranes which separate the two independent systems of blood vessels, i. e., the system of the fetus, and that of the mother. Before birth, in fact, the fetus has its blood nourished and oxygenated by means of the food partaken of by its mother, and the oxygen taken in by the mother in her breathing. After its birth, the infant eats and breathes for itself, and thus nourishes its blood supply directly, instead of receiving it indirectly from the mother.

    The Placenta begins to be formed about the third month of gestation, and continues to develop steadily from that time. At the time of the delivery of the child the Placenta covers nearly or quite one-third of the inner space of the distended Uterus of the mother. The total “afterbirth” consists of the Placenta, the umbillical cord, and the remaining membranes of the ovum, all of which are expelled after the birth of the child.

    The Amnion. An important appendage contained in the Uterus in connection with the developing fetus is that known as “The Amnion.” This is an inner sack which forms within the womb, and which serves to enclose the fetus, and also to sheath the umbillical cord. The Amnion encloses the embryo very snugly during the early stages of its development, but it gradually becomes distended with a pale watery fluid, known as “the amniotic fluid,” the purpose of which is to “float” the fetus and to give it mechanical support on all sides. This fluid is composed of water carrying in solution small quantities of albumin, urea, and salt.

    Sex in the Embryo and Fetus. It is impossible to determine the sex of the embryo during its early stages. During the fourth week the first traces of the sexual glands appear, but not until the fifth week can the sex be determined even by the microscope. If the embryo is to become a male, certain ducts are transformed into convoluted tubules, and each is attached to the testes which have been formed from the genital nucleus. If the embryo is to become a female, the ducts join to form the uterus and vagina, other portions being transformed into the fallopian tubes and connecting with the ovaries which have been formed otherwise. The outer genitals appear in the early stages of the embryo, but there is no apparent distinction between the sexes, the external organs being the same in all cases, and consisting of a small tubular organ with a small lateral fold of skin on either side. Later, in the male, a groove appears on the under side of this primitive organ, thus forming the urethra, the scrotum being formed from the folded skin at the side. In the female, the primitive organ ceases to develop as in the male, and thus becomes proportionately smaller, and evolves into the clitoris of the female; the two lateral folds, on each side, being transformed into the labia majora, or “outer lips” of the female external genitals.

    Position of the Fetus. During the period of gestation the fetus lies “curled up” in the bag of the amnion. The head is usually relaxed and inclined forward, the chin resting on the breast; the feet are bent up in front of the legs, the legs bent up on the thighs, the knees separated from each other, but the heels almost touching on the back of the thighs; the arms bent forward and the hands placed between them as though to receive the chin between them. The folded-up fetus forms an oval, the longest diameter of which is about eleven inches at its greatest stage of growth. Nature here shows a wonderful ability to pack the fetus into as little space as possible, and in such a position as to protect it from injury, and to discommode the mother as little as possible.

    The following interesting statement made by Helen Idleson, M. D., in a European medical journal several years ago, gives a very clear idea, expressed in popular terms, of the appearance and characteristics of the embryo or fetus in the various stages of its development:

    “The growth of the embryo after fecundation is very rapid. On the tenth day it has the appearance of a semi-transparent grayish flake. On the twelfth day it is nearly the size of a pea, filled with fluid, in the middle of which is an opaque spot, presenting the first appearance of an embryo, which may be clearly seen as an oblong or curved body, and is plainly visible to the naked eye on the fourteenth day. The twenty-first day the embryo resembles an ant or a lettuce seed. Many of its parts now begin to show themselves, especially the cartilaginous beginnings of the spinal column, the heart, etc. The thirtieth day the embryo is as large as a horse-fly, and resembles a worm, bent together. There are as yet no limbs, and the head is larger than the rest of the body. When stretched out it is nearly half an inch long. Toward the fifth week the heart increases greatly in proportion to the remainder of the body, and the rudimentary eyes are indicated by two black spots toward the sides, and the heart exhibits its external form, bearing a close resemblance to that in an adult. In the seventh week, bone begins to form in the lower jaw and clavicle. Narrow streaks on each side of the vertebral column show the beginning of the ribs. The heart is perfecting its form, the brain enlarging, and the eyes and ears growing more perfect, and the limbs sprouting from the body. The lungs are mere sacks, and the trachea is a delicate thread, but the liver is very large. In the seventh week are formed the renal capsules and kidneys.

    “At two months, the forearm and hand can be distinguished, but not the arm; the hand is larger than the forearm, but it is not supplied with fingers. The distinction of sex is yet difficult. The eyes are prominent. The nose forms an obtuse eminence. The nostrils are rounded and separated. The mouth is gaping, and the epidermis can be distinguished from the true skin. The embryo is from one-half to two inches long, the head forming more than one-third of the whole. At the end of three months, the eyelids are distinct but shut; the lips are drawn together; the forehead and nose are clearly traceable, and the organs of generation prominent. The heart beats with force; the larger vessels carry red blood; the fingers and toes are well defined, and the muscles begin to be developed.

    “At the fourth month, the embryo takes the name of ‘fetus.’ The body is six to eight inches in length. The skin has a rosy color, and the muscles produce a sensible motion. A fetus born at this time might live several hours. At five months the length of the body is from eight to ten inches. At six months, the length is twelve and one-half inches. The hair appears on the head, the eyes closed, the eyelids somewhat thicker, and their margins, as well as their eyebrows, are studded with very delicate hairs. At seven months, every part has been increased in volume and perfection; the bony system is nearly complete; length, twelve to fourteen inches. If born at this period, the fetus is able to breathe, cry and nurse, and may live if properly cared for.

    “At eight months, the fetus seems to grow rather in length than in thickness; it is only sixteen to eighteen inches long, and yet weighs from four to five pounds. The skin is very red, and covered with down and a considerable quantity of sebaceous matter. The lower jaw, which at first was very short, is now as long as the upper one. Finally, at term, nine months, the fetus is about nineteen to twenty-three inches long, and weighs from six to eight pounds. The red blood circulates in the capillaries, and the skin performs the functions of perspiration; the nails are fully developed.”

    Another writer says: “There is a superstition that a child born at eight months is not as liable to live as if born at seven months; indeed, many suppose that an eight months’ child never survives. Facts do not prove this idea to be correct. Personally, I have known several eight months’ babies to live and do well, and I believe that their chance of life is much greater than if born at seven months.”

    Children born in the seventh month of gestation are capable of living, though great care is required to rear them for the first few months after birth. The “incubators” now so common in large cities have greatly increased the chances of the “seven months’ child,” and, for that matter, of those born even earlier. There are a number of cases of record where children have been born after six months of gestation, and a few even before the six months, but these cases are rare and unusual, and such children usually die soon after birth.

    The following table, given by a good authority, shows the average length and weight of the human embryo and fetus:

    Age. Length in inches. Weight.
    2 weeks 0.1 Not given
    3 weeks 0.2 3 grains
    4 weeks 0.3 Not given
    5 weeks 0.5 Not given
    6 weeks 0.7 Not given
    7 weeks 0.9 Not given
    8 weeks 1.5 4 drachms
    3 months 3.0 2 ounces
    4 months 6.0 5 ounces
    5 months 9.0 10 ounces
    6 months 12.0 1 pound
    7 months 15.0 3 pounds
    8 months 17.0 5 pounds
    9 months 20.0 6 to 9 pounds

    Professor Clark holds that if at birth the infant weighs less than 5 pounds, it rarely thrives, though the records show that many infants weighing much less than this have lived and thrived. In very rare cases, infants have been known to weigh no more than one pound at birth, and to have still survived and thrived. And, on the other hand, many cases are known where infants were born, and thrived, who weighed more than twice the average weight. So, at the last, it is difficult to lay down hard and fast rules in the case.

    Delivery. At the termination of the period of gestation, the child is born into the world, and, instead of depending upon the blood of the mother for nourishment and oxygen, it begins to ingest its own food, to eliminate its own waste matter through the regular channels of the body, and to use its own lungs for the purpose of obtaining oxygen for its blood and to burn up the waste products in the lungs.

    The process of bringing a child into the world is called “parturition.” The fetus is expelled from the body of the mother by the contraction of the muscles of and around the Uterus, and also by the contraction of the abdominal walls. In the early stages of labor, the uterine muscles are brought into play; but when the fetus enters into the vaginal passage the abdominal muscles manifest their energy. The uterine and abdominal muscular movements are purely involuntary, although the mother may aid in the delivery by voluntary muscular movements. The involuntary muscular movements are due to the reflex action originating, probably, in a part of the spinal cord.

    The uterine contractions are rhythmical, and have been compared to the contraction of the muscles of the heart. Each “labor pain” begins with a minimum of contraction, the activity increasing until a maximum is reached, when it gradually decreases, only to be followed a little later by a new contraction. When the fetus is finally expelled from the Uterus (followed later by the placenta or “afterbirth”) that organ begins a gradual contraction to its normal size, shape, and condition, the restorative process usually lasting over several weeks.

    The Physical Signs of Pregnancy. The physical signs of pregnancy in the case of women of normal health are as follows:

    (1) Cessation of the menses, or menstruation. While it is true that a non-pregnant woman may occasionally pass over a menstrual period, yet as a general rule the complete cessation of a period by a married woman, particularly when the woman has previously been regular in this respect, may be considered a probable indication of pregnancy; and when the second period has been passed the probability merges almost into a certainty. An examination by a competent physician will set all doubts at rest.

    (2) Enlargement of the breasts. This indication usually manifests itself in about six or eight weeks after conception. This enlargement is usually preceded by a sensation of tingling and throbbing. The enlargement is manifested in the form of a rather hard and knotty increase, differing from the ordinary fatty increase; the lobules, arranged regularly around the nipple, are plainly distinguishable beneath the skin by means of the touch of the fingers.

    (3) Darkening of the areolar tissue surrounding the nipple. In the unimpregnated condition this tissue is of a pinkish shade; but after impregnation the shade grows darker and the circle increases in size. However, when the woman bears several children in somewhat rapid succession, this dark color may become permanent and accordingly ceases to be an indication.

    (4) Enlargement of the abdomen. This indication manifests itself about the second month, at which time the Uterus begins to elevate the intestines by rising up from the pelvis. In the fourth month the Uterus has risen so far out of the pelvis that it assumes the form and appearance of a hard round tumor. The entire abdomen then begins to enlarge. The Uterus causes an enlargement in the region of the navel at the sixth month, and the region of the diaphragm at the ninth month.

    (5) Quickening, or “signs of life.” This indication manifests first from the fourth month to the fifth—at about the exact half of the entire period of gestation. At this time, and afterward, the movements of the embryo are plainly discernable to the mother.

    The Disorders of Pregnancy. There are a number of physical disorders usually accompanying pregnancy, some of which are trifling, but some of which require the advice of a competent physician. The best plan is for the woman to consult a physician shortly after she discovers herself to be pregnant, and thereafter to visit him occasionally for advice during the period of gestation. The too common plan of postponing the call upon the physician until the eighth or ninth month is not a wise one, for in many cases the advice of a competent physician at an earlier stage of the pregnancy will obviate serious complications. The call upon the physician should usually be made not later than the third or fourth month, and positively not delayed longer than the fifth month. The physician should make an examination to ascertain whether the child is in the normal position in the Uterus, and should also examine the urine each month to ascertain whether the kidneys are functioning normally.

    What is called “morning sickness” is one of the most common of the disorders of pregnancy. It is marked by nausea or vomiting, or both, early in the morning, usually shortly after arising. Some women have at least faint symptoms of this disorder from the very beginning of conception, but usually it does not manifest until the third, fourth, or fifth week of pregnancy. It usually ceases at the end of the third or fourth month. Except in very severe cases, in which the physician should be consulted, the disorder is not serious, and requires but a little common-sense treatment, and rational habits of living. An authority says: “Eat of some fruit that best agrees with palate or stomach; drink hot water; eat nothing until a real hunger demands food. Where nausea occurs after eating, a tart apple or orange is good.” Another authority says: “Let women suffering from morning sickness try acid fruit—apples, oranges, or even lemons, if their sourness is not unpleasant. If a single orange or apple after each meal does not suffice, let them try two; let them eat ten if that number is necessary to conquer the distress. The principle is a correct one, and the relief certain. Let fruit be eaten at all hours of the day—before meals and after, on going to bed at night and at getting up in the morning. If berries are in season, let them be eaten in the natural state—that is, without sugar. If the sickness still continues, omit a meal now and then, and substitute fruit in its stead. By persistence in this course, not only will nausea be conquered, but an easy confinement guaranteed.”

    The pregnant woman often develops a capricious appetite. This disorder may manifest in one or more of several forms, as for instance: the woman may lose her appetite, and take but little food; or she may develop an abnormally large appetite, and eat much more than is necessary; or she may take a dislike to certain kinds of food—many women have an aversion toward meat during pregnancy; or she may have a “craving” for certain articles of food, sometimes for kinds of food not liked at other times, such as sour pickles, sour cabbage, etc. A little common sense, and the presence of attractive articles of fruits, etc., will do much to relieve these troubles; in extreme cases the physician’s advice will help.

    The pregnant woman should have her teeth put in good order as soon as possible, as troubles with teeth sometimes manifest themselves during pregnancy, and give much trouble and annoyance. Difficulty in urination, constipation, piles, irritation or itching of the genital organs, varicose veins, liver spots, and similar disorders, which are sometimes manifest during pregnancy, in some form or degree, should receive the attention and care of a competent physician.

    The following general advice from a competent authority is worthy of being followed: “If everything is satisfactory, if there is no severe vomiting, kidney trouble, etc., the usual mixed diet may continue. The only changes I would make are the following: Drink plenty of hot water during the entire time of pregnancy: a glass or two in the morning, two or three glasses in the afternoon, the same at night. From six to twelve glasses may be consumed. Also plenty of milk, buttermilk and fermented milk. Plenty of fruit and vegetables. Meat only once a day. For the tendency to constipation, whole wheat bread, rye bread, bread baked of bran, or bran with cream. As to exercise, either extreme must be avoided. Some women think that as soon as they become pregnant, they must not move a muscle; they are to be put in a glass case, and kept there until the date of delivery. Other women, on the other hand, of the ultra-modern type, indulge in strenuous exercise, and go out on long fatiguing walks up to the last day. Either extreme is injurious. The right way is moderate exercise, and short, non-fatiguing walks. Bathing may be kept up to the day of the delivery. But warm baths, particularly during the last two or three months, are preferable to cold baths.”

    Childbirth. The first indication of approaching delivery of the child is that of the descent of the child into the pelvis of the mother, from its former position up near the diaphragm. When this occurs, the mother usually experiences a feeling of relief, and a greater ease in breathing because of the relaxation of the former pressure on the diaphragm. Sometimes this occurs several days preceding delivery, while in other cases it occurs only a few hours before delivery. There usually occurs about the same time a slight discharge of mucus tinged with blood. The latter is called “the show,” and is caused by the unsealing of the mouth of the womb, and indicates that the Uterus is preparing to discharge its contents.

    Labor, in childbirth, consists of three stages. In the first stage, the Uterus alone contracts, and the mouth of the womb dilates; in the second stage, the abdominal muscles assist the Uterus in expelling the child; in the third stage, the Placenta (afterbirth) and membranes are expelled.

    After the delivery of the child, and after the pulsation in the umbillical cord has ceased (usually from ten to thirty minutes after delivery), the umbillical cord is severed and tied by the physician. In natural labor, the expulsion of the afterbirth occurs from within a few minutes to an hour after the delivery of the child. Nature is sometimes slow in expelling the afterbirth, but caution should be exercised in the matter of using force to assist Nature in this matter, for injury to the Uterus has often resulted from malpractice in such a case. The afterbirth is not firmly attached to the womb, but is like the peel of an orange which Nature sloughs off in due time.

    PRIVATE Sex Advice to Women By R. B. Armitage, M. D.

    For Young Wives and those who Expect to be Married.

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