Tag: birth

  • Key dates for nursing and midwifery discussions in May 2020

    Key dates for nursing and midwifery discussions in May 2020

    WHO has declared 2020 as the International Year of the Nurse and the Midwife to mark the bicentenary of the birth of the founder of modern nursing, Florence Nightingale and to recognize the critical contribution both professions make to global health. May is a key moment to catalyse high-level dialogue and collaborative engagements for moving forward the findings of The State of the World’s Nursing Report, which will be launched on World Health Day, 7 April 2020, as part of the activities of the International Year of the Nurse and the Midwife.

    Key dates for May 2020

    Ninth WHO Global Forum for Government Chief Nursing and Midwifery Officers (GCNMOs) and the Eighth Triad Meeting, 13–15 May, Geneva– organized jointly by WHO, the International Confederation of Midwives and the International Council of Nurses. The meetings will be held at the Centre International de Conférence (CICG), immediately prior to the Seventy-third World Health Assembly. (by invitation only)

    Health for All, Film Festival, 16 May (PM), Geneva – special focus on nursing and midwifery film submission

    Walk the Talk, 17 May (AM), Geneva – special focus will be given to nurses and midwives in celebration of the International Year of the Nurse and Midwife. We encourage you to register at https://www.who.int/news-room/events/detail/2020/05/17/default-calendar/walk-the-talk-the-health-for-all-challenge

    World Health Assembly 17- 20 May, Geneva

     

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  • Red Crystals and Gemstones – Healing Properties of Carnelian and Red Garnet

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    Carnelian Ancient Egyptian Source of Renewal

    Known as the Artist’s Stone it activates creativity, possibly unearthing hidden talent or latent gifts. It is an excellent stone for relieving depression, grounding, overall well-being; aids in focusing thoughts, intensify concentration, increase physical energy.

    Being a part of the Red Crystal and Gemstone family, it resonates with both the Root or Basic Chakra and the Sacral Chakra. Use this wonderful stone to cleanse and balance your Base Chakra, aligning yourself with feeling more secure and grounded.

    Ancient Egyptians believed Carnelian to be a source of vitality, sustaining the cycle of re-birth and renewal. There are references to the use of Carnelian in the Egyptian Book of the Dead. High Priests used this beautiful stone material for their Chalice as it is has the unique quality of retaining the vibration of that which was placed within. Many Chalices contained or had Silver linings molded to it, representing the Moon’s cycles of renewal and purity of its shimmering light in the night sky.

    Working with Carnelian will encourage a sense of self-trust, enabling the wearer to better discern the many choices before them. Drinking Carnelian charged water will create a sense of empowered motivation in someone who may be a bit under-motivated. It will also aid relieving depression, increasing one’s sense of self-esteem and self-empowerment.

    It can be used as a focal point during meditation or placed on the Third Eye to cleanse, balance and align your inner sight with that of the physical realm.

    *Angelic Realm Association: Archangel Raziel whose name means “Secret of God” will assist you, when asked, to remember who you truly are.

    *Healing Properties: relieves depression, stone for overall well-being, heighten concentration, increase physical energy, absorb and repel negativity.

    *Vibrational Frequency: high energy, vitality, stabilizes excess nervous energy.

    *Spiritual Properties: assists the Soul on along its journey through the physical plane, assists with being in the present moment.

    Being a personal favorite, it is one of the many crystal and gemstone bracelets I wear daily!

    Red Garnet Good Luck Stone

    The Pomegranate Seed is the inspiration for the naming of this precious stone. Its unique fiery red energy is unlike any other. In days gone by, the Garnet was used to ward off demons, protecting its wearers from phantoms in the darkness of night.

    Resonating with the second or Sacral Chakra, the Garnet aligns the wearer with abundance and prosperity, protection, enhancing relationships in a variety of ways, on many levels.

    The vibrational energy frequency of this magnificent gemstone is that of the Third Eye, clear, bright, intense, all seeing, all-knowing, piercing through cloudy shadows of dis-belief.

    The color range is deep translucent red to a very deep almost red-black color. It is often given as a token of love and fidelity.

    When placed on the Third Eye during meditation, it will cleanse negative energy, and with time enable you to see more clearly whether or not you are consciously aware of your Third Eye opening. It is more than possible for an Intuitive to access their inner sight regardless of their Third Eye being open. It is highly suggested, the Garnet be cleansed and charged in the sunlight before placing it on your Third Eye Chakra. You may choose to pass your stone through incense or over the flame of a red or white candle instead of placing it in the Sun’s rays. Whichever method you choose, always take proper precautions when working with candles or incense.

    *Angelic Realm Association: Archangel Jophiel whose name means “Beauty of God” seeing through eyes of love, enhancing all relationships especially those of the heart. Angel Israfil whose name means “The Burning One” is also associated with this gemstone, burning away imperfections, purifying the love between two people.

    *Healing Properties: personal relationships, feelings of security, passion, creativity, regulate the metabolism, feelings of lack, healing fear of the unknown.

    *Vibrational Frequency: intense, piercing, fiery purification.

    *Spiritual Properties: Third Eye activation, compassion, dream recall

    If you wish to recall a past life or incident in this life, Garnet may assist you in healing that which has come before, bringing you to where you are in this moment with compassion and love. Take heed before delving into the past; be sure you wish to re-visit an experience or situation. It may be best to allow a professional lead you through a regression.

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    Source by Terrie Marie

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  • Overcoming Mindset Challenges

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    We all have those days, we drop our heads and get down on ourselves; you might even let out a few expletive words for good measure. Our pickleball play is just not up to our, or the USAPA player rating standard. It’s frustrating. I’ll let you in on a secret I learned long ago from a coach who pushed us to achieve; your state of mind or your mindset, plays an enormous role in your successes and failure.

    Carol Dweck, author of Mindset, identifies 2 types of mind-sets; fixed and growth. The fixed mindset has shaped you from birth, it is what you are and has defined your belief in your potential. An innate conviction fashioned from external influences and internally interpreted. A fixed mindset, sees obstacles when faced with change and challenges and therefore will interpret failure as self-defeating in the lack of abilities. It’s like looking on the other side of the court and thinking that the grass is greener – your opponents seem to have all the right moves and it’s your lack of something that is keeping you from winning.

    On the other hand, the growth mindset is one that is embryonic. Here is where belief in ourselves can help us adapt and grow in the ways we want by developing our talents through hard-work and dedication. Learning to love our development playing pickleball and also developing a resilience to loss is the key.

    Hear Those “Voices”

    Learning to overcome a fixed mindset challenge begins with learning to control your emotions and then you can achieve optimal performance during competition. First, you need to pay attention to those negative voices; you know the one’s – from family members that expressed failure or the one’s from coaches that uttered a lack of talent. There may have even been laughter from classmates or club memberships. A mentor who would snap when you hit a setback. You may have developed a reactive “habit” – automatic response to an emotional stimuli. Pushing those old suppressed buttons will give you a release and an understanding but despite their best intentions, this can also trigger an emotional upheaval, easily sweeping you away. Fortunately there is one way to stop the spiral of uncontrollable emotional reactions – refocusing. Consciously stepping back to draw your focus into your senses and the physical effects they may manifest; elevated heart rate, sweaty palms, nausea, tight or tense muscles, anxiety, and shallow breathing.

    Acknowledge and Accept

    Staying in the present moment, acknowledging that these physical effects are poignant, so you can process the information as if you are a doctor observing a patient. Comprehend your emotional arousal as an imaginary threat, and your intensified state of mental stress or physical excitement is a normal response that can be reduced by controlling your emotions. Slow down. Accept that you can help your brain learn to process new “habits” to effectively stay grounded; stretch and breathe, visualize or focus on energizing cues that epitomize how you want to perform or transfer negative energy to positive energy.

    Choice

    You have a choice; interpret negative challenges or setbacks from a lack of talent fixed mindset or from a positive aptitude growth mindset. When you doubt your talent, change your focus – with time and effort, believe you can learn a particular skill or achieve a goal. If you hit a setback or face criticism, keep learning and persevere.

    When the grass on the “other side” draws my attention, I stop and reframe – finding the courage in myself to think of the “water”, or successes that keeps my grass green. I still find myself under stress, and I still hear the “voice” of my fixed mindset. I have learned to face the criticism; sometimes old responses rear their ugly head and I get angry – hitting the ball without thinking and making unforced errors. Other times I am able to put those voices in their place. I interpret my challenges, and setbacks then regain my emotional control. It’s all very personal.

    Over time, learning to take on the pickleball challenge wholeheartedly, gaining wisdom from setbacks, and acting on the criticisms you face by embracing the growth mindset can make it work for you.

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    Source by Patricia H Kuhnen-Beaver

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  • Mind, Body, Spirit Healing–Putting It into Practice

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    Modern Medicine promotes the belief that health and wellness is a crap shoot, genetically driven and at best, pure luck. If the roll of the dice isn’t in your favor or your genetic make-up has been doomed six generations back, or luck runs out, Modern Medicine has a magic pill, chemical bomb or simply cutting out whatever organ is afflicted as a solution.

    Norman Vincent Peale declared, “Change your thoughts, and you change your world.” Caroline Myss, medical intuitive extraordinaire states, “Every choice we make, every thought and feeling we have, is an act of power that has biological, environmental, social, personal and global consequences.” Wayne Dyer states, “We are responsible for everything in our lives, including whether the chemistry in our body works or doesn’t work.” If you believe health and wellness is a crap shoot, genetically driven or pure luck you have set the stage for body malfunction. If you believe as Norman Vincent Peale, Caroline Myss, PhD and Wayne Dyer, PhD, Deepak Chopra, MD believe your choices, thoughts and feelings are an act of power, and that you are responsible, then you are in control of your health.

    To be effective Mind, Body, Spirit healing needs to be practiced on a daily basis–not after your body is being ravaged by a malfunction. Mind, Body, Spirit healing is a process that maintains and supports health and wellness, thereby prevents body malfunction. People who practice Mind, Body Spirit healing avoid having cancer, MS, heart attacks, strokes, and the 101 other afflictions from A to Z, which Modern Medicine has conditioned us to be plagued by from birth to death–for many a premature death.

    The nine most frequent surgeries in America are Tonsillectomies, myringotomies, Cataract removal, Low-back surgery, Gall Bladder removal, Hysterectomies, C-Section, Sleep Apnea, Jaw pain.

    As Dr. Myss stated–“…every thought and feeling we have, is an act of power that has biological,…consequences.” In order to change any biological consequence you need to change your thoughts, which changes your feelings. Your new thoughts/beliefs must be shifted to empower you to control your health.

    To eliminate/avoid the most common reasons for surgery, it is important to know the thoughts/beliefs, which creates body malfunctions and healthy thoughts/beliefs to prevent or heal it.

    Tonsillitis, Quinsy, Sore Throat – cause: Fear, Repressed emotions, Stifled Creativity, A strong belief that you cannot speak up for yourself and ask for your needs, Feeling unable to express yourself. Holding in angry words.

    Remedy: “I release all restrictions and I am free to be me. It is my birth right to have my needs met. I now ask for what I want with love and with ease. My good now flows freely. Divine ideas express through me. I am at peace.”

    Ear Infection – cause: Anger. Not wanting to hear. Too much turmoil. Parents arguing.

    Remedy: Myringotomies are performed for recurrent ear infection, usually in children under five. Since your child is incapable of changing the thoughts/feelings you need to take the responsibility to change the child’s experience and foster the expression of feelings. Listen to and acknowledge your child’s feelings. Avoid talking at your child, talk with your child. There many excellent books on effective parenting. If there is turmoil, fighting and arguing between the parents–seek counseling to resolve your adult issues. I urge adults who have frequent colds/sore throats to use the following thought patterns. “I hear with love. Harmony surrounds me. I listen with love to the pleasant and the good. I am a center of love.”

    Cataracts – cause: Inability to see ahead with joy. Belief in a dark future.

    Remedy: “Life is eternal and filled with joy. I look forward to every moment.”

    Gall Bladder problems-cause: Bitterness. Hard thoughts. Condemning. Pride. Fear.

    Remedy: “I joyously release all hurts from the past. Life is sweet and so am I.

    Uterus/ovary problems – cause: Allowing confusion to reign. Giving power to outside influences. Rejection of the feminine processes.

    Remedy: “I am at home in my body. I am balanced in my creative flow.

    C-Section-cause: Belief in old wives tales. Belief–childbirth should be painless. Fear. Stopping the process. Rejection of the feminine processes. Unhealed aftereffects of child sexual abuse/rape or adult rape cause the memory of trauma to interfere with the natural birth process. If you are a sexual child abuse or adult rape survivor heal the emotional and physical aftereffects. See http://www.gen-assist.com to find a sexual abuse recovery specialist, traditional therapy is not effective to guide you through sexual abuse recovery.

    Remedy: Change your beliefs about childbirth. Take natural childbirth classes. A mid-wife and/or doula can lead you through a healthy delivery in the majority of instances. “I trust the process of life. I am safe. I am balanced in my creative flow.”

    Jaw Pain-cause: Anger. Resentment. Desire for revenge.

    Remedy: “I am willing to change the patterns in me that created this condition. I love and approve of myself. I am safe.”

    Sleep Apnea: Stubborn refusal to let go of old patterns, overweight or tonsil malfunction.

    Remedy: “I release all that is unlike love and joy in my mind. I move from the past into the new and fresh and vital.” Lose weight and follow remedy for tonsil malfunction.

    Low-Back Pain L-1 to L- 5 – cause: Crying for love and a need to be lonely. Insecurity. Stuck in childhood pain. See no way out. Sexual abuse. Guilt. Self-hatred. Rejection of sexuality. Financial insecurity. Fear of career. Feeling powerless. Insecurity. Difficulty in communicating. Anger. Inability to accept pleasure.

    Remedy: “I am safe in the universe and all Life loves me and supports me. I grow beyond my parents’ limitations and live for myself. It is my turn now. I release the past. I cherish myself and my beautiful sexuality. I am safe. I love who I am. I am grounded in my own power. I am secure on all levels. I deserve to enjoy life. I ask for what I want and I accept with joy and pleasure.”

    Tip: Write these thoughts on a 3X5 card. Read them silently or out loud 3 times upon awakening and before going to sleep. Have a copy with you, if you notice you are running the old tapes in your head, read the new thought pattern. Within 30 – 45 days you will notice you feel better, more energized and have a sense of relief.

    The food we eat or lack of proper nutrition contributes to physical malfunction. I will discuss nutritional needs–titled Holistic Nutrition.

    Article resource: Heal Your Body, Louise Hay.

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    Source by Dorothy M. Neddermeyer, PhD

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  • e-Marketing Strategy: 7 Dimensions to Consider (the e-Marketing Mix)

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    What is e-Marketing?

    e-Marketing is still quite a controversial subject to talk about, since no one succeeded to unify the various theories around it; however there is one thing upon which there is no doubt – that e-Marketing first appeared under the form of various techniques deployed by pioneer companies selling their products via the internet in the early 90’s.

    The frenzy around these new marketing techniques created by e-tailers and supported by the internet rapidly gave birth to a new dimension of what we knew as Marketing: the e-Marketing (electronic Marketing).

    There are many definitions to what e-Marketing is, the simplest and shortest one being formulated by Mark Sceats: e-Marketing is Marketing that uses the internet as manifestation media. A working definition is that coming from a group of CISCO specialists: e-Marketing is the sum of all activities a business conducts through the internet with the purpose of finding, attracting, winning and retaining customers.

    e-Marketing Strategy

    The e-Marketing Strategy is normally based and built upon the principles that govern the traditional, offline Marketing – the well-known 4 P’s (Product – Price – Promotion – Positioning) that form the classic Marketing mix. Add the extra 3 P’s (People – Processes – Proof) and you got the whole extended Marketing mix.

    Until here, there are no much aspects to differentiate e-Marketing from the traditional Marketing performed offline: the extended Marketing mix (4 + 3 P’s) is built around the concept of “transactional” and its elements perform transactional functions defined by the exchange paradigm. What gives e-Marketing its uniqueness is a series of specific functions, relational functions, that can be synthesized in the 2P + 2C+ 3S formula: Personalization, Privacy, Customer Service, Community, Site, Security, Sales Promotion.

    These 7 functions of the e-Marketing stay at the base of any e-Marketing strategy and they have a moderating character, unlike the classic Marketing mix that comprises situational functions only. Moderating functions of e-Marketing have the quality of moderate, operate upon all situational functions of the mix (the classic 4 P’s) and upon each other.

    1. Personalization

    The fundamental concept of personalization as a part of the e-Marketing mix lies in the need of recognizing, identifying a certain customer in order to establish relations (establishing relations is a fundamental objective of Marketing). It is crucial to be able to identify our customers on individual level and gather all possible information about them, with the purpose of knowing our market and be able to develop customized, personalized products and services.

    For example, a cookie strategically placed on the website visitor’s computer can let us know vital information concerning the access speed available: in consequence, if we know the visitor is using a slow connection (eg. dial-up) we will offer a low-volume variation of our website, with reduced graphic content and no multimedia or flash applications. This will ease our customer’s experience on our website and he will be prevented from leaving the website on the reason that it takes too long to load its pages.

    Personalization can be applied to any component of the Marketing mix; therefore, it is a moderating function.

    2. Privacy

    Privacy is an element of the mix very much connected to the previous one – personalization. When we gather and store information about our customers and potential customers (therefore, when we perform the personalization part of the e-Marketing mix) a crucial issue arises: that of the way this information will be used, and by whom. A major task to do when implementing an e-Marketing strategy is that of creating and developing a policy upon access procedures to the collected information.

    This is a duty and a must for any conscious marketer to consider all aspects of privacy, as long as data are collected and stored, data about individual persons.

    Privacy is even more important when establishing the e-Marketing mix since there are many regulations and legal aspects to be considered regarding collection and usage of such information.

    3. Customer Service

    Customer service is one of the necessary and required activities among the support functions needed in transactional situations.

    We will connect the apparition of the customer service processes to the inclusion of the “time” parameter in transactions. When switching from a situational perspective to a relational one, and e-Marketing is mostly based on a relational perspective, the marketer saw himself somehow forced into considering support and assistance on a non-temporal level, permanently, over time.

    For these reasons, we should consider the Customer Service function (in its fullest and largest definition) as an essential one within the e-Marketing mix.

    As we can easily figure out, the service (or assistance if you wish) can be performed upon any element from the classic 4 P’s, hence its moderating character.

    4. Community

    We can all agree that e-Marketing is conditioned by the existence of this impressive network that the internet is. The merely existence of such a network implies that individuals as well as groups will eventually interact. A group of entities that interact for a common purpose is what we call a “community” and we will soon see why it is of absolute importance to participate, to be part of a community.

    The Metcalf law (named after Robert Metcalf) states that the value of a network is given by the number of its components, more exactly the value of a network equals the square of the number of components. We can apply this simple law to communities, since they are a network: we will then conclude that the value of a community rises with the number of its members. This is the power of communities; this is why we have to be a part of it.

    The customers / clients of a business can be seen as part of a community where they interact (either independent or influenced by the marketer) – therefore developing a community is a task to be performed by any business, even though it is not always seen as essential.

    Interactions among members of such a community can address any of the other functions of e-Marketing, so it can be placed next to other moderating functions.

    5. Site

    We have seen and agreed that e-Marketing interactions take place on a digital media – the internet. But such interactions and relations also need a proper location, to be available at any moment and from any place – a digital location for digital interactions.

    Such a location is what we call a “site”, which is the most widespread name for it. It is now the time to mention that the “website” is merely a form of a “site” and should not be mistaken or seen as synonyms. The “site” can take other forms too, such as a Palm Pilot or any other handheld device, for example.

    This special location, accessible through all sort of digital technologies is moderating all other functions of the e-Marketing – it is then a moderating function.

    6. Security

    The “security” function emerged as an essential function of e-Marketing once transactions began to be performed through internet channels.

    What we need to keep in mind as marketers are the following two issues on security:

    – security during transactions performed on our website, where we have to take all possible precautions that third parties will not be able to access any part of a developing transaction;

    – security of data collected and stored, about our customers and visitors.

    A honest marketer will have to consider these possible causes of further trouble and has to co-operate with the company’s IT department in order to be able to formulate convincing (and true, honest!) messages towards the customers that their personal details are protected from unauthorized eyes.

    7. Sales Promotion

    At least but not last, we have to consider sales promotions when we build an e-Marketing strategy. Sales promotions are widely used in traditional Marketing as well, we all know this, and it is an excellent efficient strategy to achieve immediate sales goals in terms of volume.

    This function counts on the marketer’s ability to think creatively: a lot of work and inspiration is required in order to find new possibilities and new approaches for developing an efficient promotion plan.

    On the other hand, the marketer needs to continuously keep up with the latest internet technologies and applications so that he can fully exploit them.

    To conclude, we have seen that e-Marketing implies new dimensions to be considered aside of those inherited from the traditional Marketing. These dimensions revolve around the concept of relational functions and they are a must to be included in any e-Marketing strategy in order for it to be efficient and deliver results.

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    Source by Otilia Otlacan

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  • 4 Herbal Remedies For Bacterial Vaginosis That Work Exceedingly Well to Cure BV

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    Women who suffer from bacterial vaginosis (BV) are normally recommended antibiotics and topical creams by conventional doctors. However these are not the only options to treat this problem. There are some extremely effective herbal remedies for bacterial vaginosis that can help you get rid of recurring vaginal bacteria infection.

    When the bad bacteria dominates the vagina of a women then one can experience itching, swelling, inflammation, vaginal discharge, pain during sex, pain while urinating and several other symptoms. However one should visit a doctor when any of the above symptoms are noticed.

    Both vaginal yeast infection and bacterial vaginosis have very similar symptoms and this is the reason one should visit a doctor and get the problem properly examined.

    Herbal remedies for bacterial vaginosis work by killing the bad bacteria that causes this problem. These remedies however do not kill the good bacteria that is so essential for preventing this problem from happening again and again.

    Unfortunately women turn to birth control pills and antibiotics that actually disturb the ph balance in the vagina by killing both the good and the bad bacteria. This is the main reason for this problem occurring again and again.

    Here are 4 herbal remedies for bacterial vaginosis that work extremely well:

    1) Garlic pearls or capsules have excellent anti bacterial and anti fungal properties. Make sure to have capsules of correct potency so that it really works to get rid of vaginal bacteria infection. You may have to take these capsules twice a day till you get rid of the problem completely.

    2) Another excellent herbal remedy is an acidophilus pill. Take these pills orally every day. This will help in restoring the vaginal flora to slightly acidic so that BV is prevented.

    3) One of the best herbal remedies for bacterial vaginosis is olive leaf extract. Olive leaf extract helps in treating and preventing BV. This extract is also available in the form of capsules. Follow the dosage details and take the capsules regularly for getting good results.

    4) If you can dilute tea tree oil with olive oil and apply it to the vagina topically you will be able to get rid of vaginal bacteria infection very fast.

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    Source by Lynda Johnson

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  • Heal Your Broken Heart With Heart Touching Poems

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    Being in love is an amazing experience in itself. Countless days and nights thinking about someone and the moments you spend with them takes you in a world which is far away from reality and seems just like heaven. Lots of promises and commitments for spending the life together is an essence that can never be forgotten. Unfortunately, all the couples are not so blessed; they have to face the separation in the mean of their love journey.

    Whatever the reason may be either the circumstances or the misunderstandings, it seems like all the happiness is going too far from their life. At that time one feels that he should lock himself in a dark room and keep on talking with those memories. It feels like the whole world is laughing on the separation of two hearts.

    Generally, those broken heart guys love to read their previous chats, messages, and letters again and again. No one knows why people do this while the fact is it’s the power of words that take them to rewind all their memorable moments and tears automatically comes out of their eyes. World witnessed that power of word can change an enemy into a friend and vice-versa.

    Love poem have proved their significant existence in the life of the broken heart guys. These love separations have given birth to popular poets. Every one of them has their own love story and unforgettable memories behind those words of the poem. If you are also among the ones that are not so blessed to have your partner with you for lifetime and one thing may work in your favor at this time.

    Try to write your feelings in the form of poem instead of sharing them with all. Once people will show you sympathy but they will not listen to you again and again. And a time will come when they may also hurt you by making fun of your feelings.

    Writing such poems will not only give your heart a relief but a writer may come out from you. With time it may become your hobby which may transform into strength. Though, it’s also true no one can forget their first love. But, sooner or later everyone has to overcome from this deadly experience.

    Remember that, you are doing this for your own benefit. Because when you will complete one poem you will definitely feel the need to write the other. You may notice that different elements of your pain come out of your heart – at first may be pity and then regret but definitely a glimmer of hope will come someday. Just keep on writing whatever bubble ups from the heart to the surface of your mind. Always remember that time is the biggest ointment that will definitely fade out those memories from your life. No matter how far the person has moved away you will definitely learn to live a happy life.

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    Source by Sarika Kataria

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  • Attractive New Regenerative Medicine Tool Uses Magnets to Shape and Stimulate Stem Cells

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    How would it have been if we could develop embryoid bodies (EBs) from individual embryonic stem cells (ESCs) using technology? This could give birth to the development of the regenerative medicines and other therapies, which does not require an external supporting matrix as needed by the traditional regenerative technology to create a coordinated assembly.

    All this is possible with a cellular magnetic Legos. A technology developed by the researchers at the Laboratoire Matiere et Systemes Complexes (CNRS/Universite Paris Diderot) is capable of combining cells with the help of magnetic nanoparticles and magnetized miniaturized magnets. In order to differentiate, it does not need any supporting matrix. The best part of this technology is that it can develop any tissues and deform them at will.

    An elaborate insight of the study has been detailed in Nature Communications. This tool infused with miniaturized magnets can be used as a great technology in the field of regenerative medicines and also in biophysical studies.

    Since the demand of nanotechnology is ever growing for providing an unprecedented solution for diagnosis and regenerative therapy, we can feel its necessity in every sphere of medicines and biosciences. Hence, this finding is another milestone for the development of regenerative tissues or therapies sans an external supporting matrix.

    However, for scientists it is not viable to use matrix for the development of cohesive and organized cellular assembly for tissue generation. This is what they find it a great challenge, especially when they have to work on synthesizing thick or large sized organ or tissue. Or sometimes, the stimulation of these tissues is quite tough as they refuse to function properly as opposed to their counterpart cartilage.

    Magnetic Cellular Lego At Scientists’ Assistance

    A new tool developed by the scientists in France, uses magnetized stem cells to alter and stimulate stem cells into 3D shapes. By using external magnets, cells can be magnetized for differentiation, assembly, proliferation and stimulation through insertion of nanoparticles. This way, these cells are turning into cellular magnetic Legos. The magnetic Legos performs as a magnetic tissue stretcher, where mobile magnets captivate aggregate developed from the cells before a second the micromagnet could attract magnetized cells. The experimenting tissues on the magnetic tray behave independently (say compression and stretching) influenced by the two actuated magnets.

    The Method Of The Experiments

    The first approach of the study was to gauge the capacity of the magnetized cells to differentiate and proliferate as similar as stem cells, and also zap pluripotency characteristic in embryonic stem cells when introduced to nanoparticles. It was aimed at developing the embryoid body applying the differentiation process of embryonic stem cells. We can call embryoid bodies as 3D groups of pluripotent stem cells, which comprise three types of skin cell types. The team further found that nanoparticles do not impact the formation of embryoid bodies in the magnetic stretcher.

    In order to form embryoid bodies using magnetized cells, it has more effective outcomes as opposed to the hanging drop method, where embryoid bodies cannot proliferate properly.

    The study further showed that the addition of the nanoparticles to the embryonic stem cells do not put any impact on its differentiation process. Simultaneously, the embryoid bodies could move toward the heart muscle in the magnetic stretcher when stimulated by magnetic cells. Thus, it proved that other than living orgasmic cells, the mechanical factors like magnetic cells can take part in the process of cell differentiation too.

    We can hope that by using this all-in-technology, we can generate tissues by manipulating stem cells, or use it as a powerful method to enhance biophysical learning possibilities.

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    Source by Richa Verma

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